Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD. - Wikidata - awgldk - TriplyDB

Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD.

Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD.

http://www.wikidata.org/entity/Q35849949

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Mechanisms of STAT protein activation by oncogenic KIT mutants in neoplastic mast cells Structural and functional alterations of FLT3 in acute myeloid leukemia FLT3 mutations in acute myeloid leukemia: what is the best approach in 2013?Survey of activated FLT3 signaling in leukemia STAT5 requires the N-domain for suppression of miR15/16, induction of bcl-2, and survival signaling in myeloproliferative disease Using combination therapy to override stromal-mediated chemoresistance in mutant FLT3-positive AML: synergism between FLT3 inhibitors, dasatinib/multi-targeted inhibitors and JAK inhibitors.A robust error model for iTRAQ quantification reveals divergent signaling between oncogenic FLT3 mutants in acute myeloid leukemia.FLT3 and NPM1 mutations in Chinese patients with acute myeloid leukemia and normal cytogenetics.The Future of Targeting FLT3 Activation in AML.Pim-1 kinase phosphorylates and stabilizes 130 kDa FLT3 and promotes aberrant STAT5 signaling in acute myeloid leukemia with FLT3 internal tandem duplication Activating FLT3 mutants show distinct gain-of-function phenotypes in vitro and a characteristic signaling pathway profile associated with prognosis in acute myeloid leukemia.Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis Targeting CDK1 promotes FLT3-activated acute myeloid leukemia differentiation through C/EBPα.FLT3 mutations confer enhanced proliferation and survival properties to multipotent progenitors in a murine model of chronic myelomonocytic leukemia.A STATus report on DC development.Adaptor protein Lnk binds to and inhibits normal and leukemic FLT3.Regulation of myeloproliferation and M2 macrophage programming in mice by Lyn/Hck, SHIP, and Stat5 Potentiation of antileukemic therapies by the dual PI3K/PDK-1 inhibitor, BAG956: effects on BCR-ABL- and mutant FLT3-expressing cells.Structural and numerical variation of FLT3/ITD in pediatric AML.Mutation of NPM1 and FLT3 genes in acute myeloid leukemia and their association with clinical and immunophenotypic features.FLT3-ITD up-regulates MCL-1 to promote survival of stem cells in acute myeloid leukemia via FLT3-ITD-specific STAT5 activation.FLT3 inhibition and mechanisms of drug resistance in mutant FLT3-positive AML.The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo.STAT5 is crucial to maintain leukemic stem cells in acute myelogenous leukemias induced by MOZ-TIF2.G-749, a novel FLT3 kinase inhibitor, can overcome drug resistance for the treatment of acute myeloid leukemia.Bench to bedside targeting of FLT3 in acute leukemia.Differential signaling of Flt3 activating mutations in acute myeloid leukemia: a working model.FLT3 inhibition: a moving and evolving target in acute myeloid leukaemia.STAT5-mediated self-renewal of normal hematopoietic and leukemic stem cells.The role of quizartinib in the treatment of acute myeloid leukemia.FLT3 inhibitors in AML: are we there yet?c-Cbl and Cbl-b ligases mediate 17-allylaminodemethoxygeldanamycin-induced degradation of autophosphorylated Flt3 kinase with internal tandem duplication through the ubiquitin proteasome pathway.STAT3 Inhibition Induces Apoptosis in Cancer Cells Independent of STAT1 or STAT2.KIT-D816V oncogenic activity is controlled by the juxtamembrane docking site Y568-Y570.Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice.Prognostic implications of NPM1 mutations and FLT3 internal tandem duplications in Egyptian patients with cytogenetically normal acute myeloid leukemia.Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling.Interleukin-7-induced Stat-5 acts in synergy with Flt-3 signaling to stimulate expansion of hematopoietic progenitor cells.Effective targeting of STAT5-mediated survival in myeloproliferative neoplasms using ABT-737 combined with rapamycin Prolonged cellular midostaurin retention suggests potential alternative dosing strategies for FLT3-ITD-positive leukemias.

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P2860

Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD.

http://www.wikidata.org/entity/Q35849949

description

2006 nî lūn-bûn

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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2006年论文

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2006年论文

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name

Roles of tyrosine 589 and 591 ...... ormation mediated by FLT3-ITD.

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Roles of tyrosine 589 and 591 ...... ormation mediated by FLT3-ITD.

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type

label

Roles of tyrosine 589 and 591 ...... ormation mediated by FLT3-ITD.

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Roles of tyrosine 589 and 591 ...... ormation mediated by FLT3-ITD.

@en

prefLabel

Roles of tyrosine 589 and 591 ...... ormation mediated by FLT3-ITD.

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Roles of tyrosine 589 and 591 ...... ormation mediated by FLT3-ITD.

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Roles of tyrosine 589 and 591 ...... ormation mediated by FLT3-ITD.

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P2093

Benjamin H Lee

http://www.w3.org/2001/XMLSchema#string

D Gary Gilliland

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David P Schenkein

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Jennifer L Rocnik

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Jin-Chen Yu

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Neill Giese

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Rachel Okabe

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P2860

Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases

Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs

The pim-1 oncogene encodes two related protein-serine/threonine kinases by alternative initiation at AUG and CUG

Valosin-containing protein phosphorylation at Ser784 in response to DNA damage

The structural basis for autoinhibition of FLT3 by the juxtamembrane domain

Targeted mutations of the juxtamembrane tyrosines in the Kit receptor tyrosine kinase selectively affect multiple cell lineages

Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells.

Murine Flt3, a gene encoding a novel tyrosine kinase receptor of the PDGFR/CSF1R family.

The roles of FLT3 in hematopoiesis and leukemia.

Essential role of signal transducer and activator of transcription (Stat)5a but not Stat5b for Flt3-dependent signaling.

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16627759

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