The E3 ubiquitin ligase WWP1 selectively targets HER4 and its proteolytically derived signaling isoforms for degradation
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Binding of RhoA by the C2 domain of E3 ligase Smurf1 is essential for Smurf1-regulated RhoA ubiquitination and cell protrusive activityWW domain containing E3 ubiquitin protein ligase 1 targets the full-length ErbB4 for ubiquitin-mediated degradation in breast cancerReceptor tyrosine kinases in the nucleusRegulation of ERBB3/HER3 signaling in cancerCell death or survival promoted by alternative isoforms of ErbB4Nuclear localization of orphan receptor protein kinase (Ror1) is mediated through the juxtamembrane domain.ERBB3: A potential serum biomarker for early detection and therapeutic target for devil facial tumour 1 (DFT1)Acute doxorubicin cardiotoxicity is associated with miR-146a-induced inhibition of the neuregulin-ErbB pathway.E3 ubiquitin ligases in ErbB receptor quantity control.The E3 ubiquitin ligase NEDD4 negatively regulates HER3/ErbB3 level and signaling.Functional Characterization of a WWP1/Tiul1 Tumor-derived Mutant Reveals a Paradigm of Its Constitutive Activation in Human Cancer.A general strategy for generating intact, full-length IgG antibodies that penetrate into the cytosol of living cells.The ubiquitin E3 ligase WWP1 decreases CXCL12-mediated MDA231 breast cancer cell migration and bone metastasis.NEDD4 single nucleotide polymorphism rs2271289 is associated with keloids in Chinese Han population.ErbB4 splice variants Cyt1 and Cyt2 differ by 16 amino acids and exert opposing effects on the mammary epithelium in vivo.Molecular origin of the binding of WWOX tumor suppressor to ErbB4 receptor tyrosine kinase.Potential of ErbB4 antibodies for cancer therapy.WWP1: a versatile ubiquitin E3 ligase in signaling and diseases.A data mining approach for identifying pathway-gene biomarkers for predicting clinical outcome: A case study of erlotinib and sorafenib.Ubiquitination and the Regulation of Membrane Proteins.The WWP1 ubiquitin E3 ligase increases TRAIL resistance in breast cancer.The anti-HER3 (ErbB3) therapeutic antibody 9F7-F11 induces HER3 ubiquitination and degradation in tumors through JNK1/2- dependent ITCH/AIP4 activation.Knockdown of WWP1 inhibits growth and invasion, but induces apoptosis of osteosarcoma cells.Featured Article: Nuclear export of opioid growth factor receptor is CRM1 dependentSignaling by ERBB4WWOX binds ERBB4s80ERBB4s80 binds YAP1ERBB4 binds WWP1/ITCH ubiquitin ligasesERBB4 ubiquitination by WWP1/ITCHWWP1 as a potential tumor oncogene regulates PTEN-Akt signaling pathway in human gastric carcinoma.High expression of WWP1 predicts poor prognosis and associates with tumor progression in human colorectal cancer.
P2860
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P2860
The E3 ubiquitin ligase WWP1 selectively targets HER4 and its proteolytically derived signaling isoforms for degradation
description
2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2009
@ast
im Februar 2009 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2009/02/01)
@sk
vědecký článek publikovaný v roce 2009
@cs
wetenschappelijk artikel (gepubliceerd op 2009/02/01)
@nl
наукова стаття, опублікована в лютому 2009
@uk
مقالة علمية (نشرت في فبراير 2009)
@ar
name
The E3 ubiquitin ligase WWP1 s ...... aling isoforms for degradation
@ast
The E3 ubiquitin ligase WWP1 s ...... aling isoforms for degradation
@en
The E3 ubiquitin ligase WWP1 s ...... aling isoforms for degradation
@nl
type
label
The E3 ubiquitin ligase WWP1 s ...... aling isoforms for degradation
@ast
The E3 ubiquitin ligase WWP1 s ...... aling isoforms for degradation
@en
The E3 ubiquitin ligase WWP1 s ...... aling isoforms for degradation
@nl
prefLabel
The E3 ubiquitin ligase WWP1 s ...... aling isoforms for degradation
@ast
The E3 ubiquitin ligase WWP1 s ...... aling isoforms for degradation
@en
The E3 ubiquitin ligase WWP1 s ...... aling isoforms for degradation
@nl
P2093
P2860
P3181
P356
P1476
The E3 ubiquitin ligase WWP1 s ...... aling isoforms for degradation
@en
P2093
Azeddine Atfi
Debra Hunter
H. Shelton Earp
Keiji Miyazawa
Laura S. Caskey
Melissa A. Sandahl
Rebecca S. Muraoka-Cook
Shu-Mang Feng
P2860
P304
P3181
P356
10.1128/MCB.00595-08
P407
P577
2009-02-01T00:00:00Z