The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation - Wikidata - awgldk - TriplyDB

The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation

The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation

http://www.wikidata.org/entity/Q24563226

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Ablation of Smurf2 reveals an inhibition in TGF-β signalling through multiple mono-ubiquitination of Smad3 WW domain containing E3 ubiquitin protein ligase 1 targets the full-length ErbB4 for ubiquitin-mediated degradation in breast cancer Identification of PCTA, a TGIF antagonist that promotes PML function in TGF-beta signalling Transforming growth interacting factor expression in leiomyoma compared with myometrium Key role for ubiquitin protein modification in TGFβ signal transduction Regulation of TGF-β Superfamily Signaling by SMAD Mono-Ubiquitination The TGF-β/Smad repressor TG-interacting factor 1 (TGIF1) plays a role in radiation-induced intestinal injury independently of a Smad signaling pathway TGIF governs a feed-forward network that empowers Wnt signaling to drive mammary tumorigenesis Ubiquitin E3 ligase WWP1 as an oncogenic factor in human prostate cancer The E3 ubiquitin ligase WWP1 selectively targets HER4 and its proteolytically derived signaling isoforms for degradation EGF antagonizes TGF-beta-induced tropoelastin expression in lung fibroblasts via stabilization of Smad corepressor TGIF Premature senescence and increased TGFβ signaling in the absence of Tgif1.TGIF inhibits retinoid signaling Ezrin ubiquitylation by the E3 ubiquitin ligase, WWP1, and consequent regulation of hepatocyte growth factor receptor activity Tgif1 and Tgif2 Repress Expression of the RabGAP Evi5l.Tgif1 regulates quiescence and self-renewal of hematopoietic stem cells Engulfment protein GULP is regulator of transforming growth factor-β response in ovarian cells.Otitis media in the Tgif knockout mouse implicates TGFβ signalling in chronic middle ear inflammatory disease.Splicing factor 3b subunit 4 binds BMPR-IA and inhibits osteochondral cell differentiation.Tiul1 and TGIF are Involved in Downregulation of TGFbeta1-induced IgA Isotype Expression.Targeted disruption of Tgif, the mouse ortholog of a human holoprosencephaly gene, does not result in holoprosencephaly in mice.Progression of BRAF-induced thyroid cancer is associated with epithelial-mesenchymal transition requiring concomitant MAP kinase and TGFβ signaling.The regulation of TGF-β/SMAD signaling by protein deubiquitination.The endogenous ratio of Smad2 and Smad3 influences the cytostatic function of Smad3.Bcr-Abl activates the AKT/Fox O3 signalling pathway to restrict transforming growth factor-beta-mediated cytostatic signals.Ubiquitin-dependent regulation of TGFbeta signaling in cancer Functional Characterization of a WWP1/Tiul1 Tumor-derived Mutant Reveals a Paradigm of Its Constitutive Activation in Human Cancer.The disintegrin and metalloproteinase ADAM12 contributes to TGF-beta signaling through interaction with the type II receptor Essential role of plasminogen activator inhibitor type-1 in radiation enteropathy Overexpression of WWP1 promotes tumorigenesis and predicts unfavorable prognosis in patients with hepatocellular carcinoma.Secretory leukocyte protease inhibitor reverses inhibition by CNS myelin, promotes regeneration in the optic nerve, and suppresses expression of the transforming growth factor-β signaling protein Smad2.Transforming growth factor-beta signaling and ubiquitinators in cancer.To (TGF)beta or not to (TGF)beta: fine-tuning of Smad signaling via post-translational modifications Regulation of TGF-beta family signaling by E3 ubiquitin ligases.Identification of a novel negative regulator of activin/nodal signaling in mesendodermal formation of Xenopus embryos.Smad7: not only a regulator, but also a cross-talk mediator of TGF-β signalling.Role of Smads in TGFβ signaling.How ubiquitination regulates the TGF-β signalling pathway: new insights and new players: new isoforms of ubiquitin-activating enzymes in the E1-E3 families join the game.WWP1: a versatile ubiquitin E3 ligase in signaling and diseases.Regulation of the transforming growth factor β pathway by reversible ubiquitylation.

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P2860

The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation

http://www.wikidata.org/entity/Q24563226

description

2004 nî lūn-bûn

@nan

2004 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2004年の論文

@ja

2004年学术文章

@wuu

2004年学术文章

@zh-cn

2004年学术文章

@zh-hans

2004年学术文章

@zh-my

2004年学术文章

@zh-sg

2004年學術文章

@yue

name

The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation

@ast

The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation

@en

The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation

@nl

type

label

The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation

@ast

The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation

@en

The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation

@nl

prefLabel

The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation

@ast

The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation

@en

The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation

@nl

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SJ.EMBOJ.7600398

P1433

The EMBO Journal

P1476

The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation

@en

P2093

Azeddine Atfi

http://www.w3.org/2001/XMLSchema#string

François Lallemand

http://www.w3.org/2001/XMLSchema#string

Jacques Camonis

http://www.w3.org/2001/XMLSchema#string

Marcia Pessah

http://www.w3.org/2001/XMLSchema#string

Nathalie Ferrand

http://www.w3.org/2001/XMLSchema#string

Su Ryeon Seo

http://www.w3.org/2001/XMLSchema#string

Sébastien L'Hoste

http://www.w3.org/2001/XMLSchema#string

P2860

A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling

Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation

A mechanism of suppression of TGF-beta/SMAD signaling by NF-kappa B/RelA

c-Jun interacts with the corepressor TG-interacting factor (TGIF) to suppress Smad2 transcriptional activity

A system for stable expression of short interfering RNAs in mammalian cells

TGF-beta signalling from cell membrane to nucleus through SMAD proteins

The interaction of the carboxyl terminus-binding protein with the Smad corepressor TGIF is disrupted by a holoprosencephaly mutation in TGIF

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3780-92

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scholarly article

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10.1038/SJ.EMBOJ.7600398

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P433

19

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23

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2004-10-01T00:00:00Z

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8355480

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15359284

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522797

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