Production of 22-hydroxy metabolites of vitamin d3 by cytochrome p450scc (CYP11A1) and analysis of their biological activities on skin cells - Wikidata - awgldk - TriplyDB

Production of 22-hydroxy metabolites of vitamin d3 by cytochrome p450scc (CYP11A1) and analysis of their biological activities on skin cells

Production of 22-hydroxy metabolites of vitamin d3 by cytochrome p450scc (CYP11A1) and analysis of their biological activities on skin cells

http://www.wikidata.org/entity/Q35187882

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Vitamin D derivatives enhance cytotoxic effects of H2O2 or cisplatin on human keratinocytes Novel vitamin D analogs as potential therapeutics: metabolism, toxicity profiling, and antiproliferative activity.RORα and ROR γ are expressed in human skin and serve as receptors for endogenously produced noncalcemic 20-hydroxy- and 20,23-dihydroxyvitamin D.Metabolism of 20-hydroxyvitamin D3 by mouse liver microsomes Lumisterol is metabolized by CYP11A1: discovery of a new pathway Metabolism of 20-hydroxyvitamin D3 and 20,23-dihydroxyvitamin D3 by rat and human CYP24A1 Human cytochrome P450scc (CYP11A1) catalyzes epoxide formation with ergosterol.Detection of novel CYP11A1-derived secosteroids in the human epidermis and serum and pig adrenal gland.In vivo evidence for a novel pathway of vitamin D₃ metabolism initiated by P450scc and modified by CYP27B1.Chemical Synthesis and Biological Activities of 20S,24S/R-Dihydroxyvitamin D3 Epimers and Their 1α-Hydroxyl Derivatives.On the role of skin in the regulation of local and systemic steroidogenic activities.Novel activities of CYP11A1 and their potential physiological significance.Hydroxylation of 20-hydroxyvitamin D3 by human CYP3A4.Hydroxylation of CYP11A1-derived products of vitamin D3 metabolism by human and mouse CYP27B1.Cytochromes p450 and skin cancer: role of local endocrine pathways.De novo synthesis of steroids and oxysterols in adipocytes Novel vitamin D photoproducts and their precursors in the skin.Noncalcemic 20-hydroxyvitamin D3 inhibits human melanoma growth in in vitro and in vivo models In vivo production of novel vitamin D2 hydroxy-derivatives by human placentas, epidermal keratinocytes, Caco-2 colon cells and the adrenal gland.The role of CYP11A1 in the production of vitamin D metabolites and their role in the regulation of epidermal functions.Novel non-calcemic secosteroids that are produced by human epidermal keratinocytes protect against solar radiation.On the role of classical and novel forms of vitamin D in melanoma progression and management.PTH and Vitamin D.Novel vitamin D hydroxyderivatives inhibit melanoma growth and show differential effects on normal melanocytes.20-hydroxyvitamin D₃ inhibits proliferation of cancer cells with high efficacy while being non-toxic.Rat CYP24A1 acts on 20-hydroxyvitamin D(3) producing hydroxylated products with increased biological activity.Synthesis and Biological Evaluation of Vitamin D3 Metabolite 20S,23S-Dihydroxyvitamin D3 and Its 23R Epimer.Correlation between secosteroid-induced vitamin D receptor activity in melanoma cells and computer-modeled receptor binding strength.Design, synthesis, and biological action of 20R-hydroxyvitamin D3.Metabolism of cholesterol, vitamin D3 and 20-hydroxyvitamin D3 incorporated into phospholipid vesicles by human CYP27A1 Expression of human CYP27B1 in Escherichia coli and characterization in phospholipid vesicles.Bioactive forms of vitamin D selectively stimulate the skin analog of the hypothalamus-pituitary-adrenal axis in human epidermal keratinocytes.Investigation of 20S-hydroxyvitamin D3 analogs and their 1α-OH derivatives as potent vitamin D receptor agonists with anti-inflammatory activities.Vitamin D signaling and melanoma: role of vitamin D and its receptors in melanoma progression and management.CYP27A1 acts on the pre-vitamin D3 photoproduct, lumisterol, producing biologically active hydroxy-metabolites.Properties of purified CYP2R1 in a reconstituted membrane environment and its 25-hydroxylation of 20-hydroxyvitamin D3.Endogenously produced nonclassical vitamin D hydroxy-metabolites act as "biased" agonists on VDR and inverse agonists on RORα and RORγ.

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Production of 22-hydroxy metabolites of vitamin d3 by cytochrome p450scc (CYP11A1) and analysis of their biological activities on skin cells

http://www.wikidata.org/entity/Q35187882

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2011 nî lūn-bûn

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2011 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2011年の論文

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Drug Metabolism and Disposition

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Production of 22-hydroxy metab ...... gical activities on skin cells

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Danielle E Howell

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Donna M Baldisseri

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Haleem Z Shehabi

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Heather A E Benson

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Jianjun Chen

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Minh N Nguyen

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Robert C Tuckey

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Tae-Kang Kim

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Trevor Sweatman

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Wei Li

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P2860

Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system

Structural Basis for Three-step Sequential Catalysis by the Cholesterol Side Chain Cleavage Enzyme CYP11A1

Sequential metabolism of 7-dehydrocholesterol to steroidal 5,7-dienes in adrenal glands and its biological implication in the skin

THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE

20-Hydroxycholecalciferol, product of vitamin D3 hydroxylation by P450scc, decreases NF-kappaB activity by increasing IkappaB alpha levels in human keratinocytes.

Products of vitamin D3 or 7-dehydrocholesterol metabolism by cytochrome P450scc show anti-leukemia effects, having low or absent calcemic activity.

A novel pathway for sequential transformation of 7-dehydrocholesterol and expression of the P450scc system in mammalian skin

Purified mouse CYP27B1 can hydroxylate 20,23-dihydroxyvitamin D3, producing 1alpha,20,23-trihydroxyvitamin D3, which has altered biological activity

Enzymes involved in the activation and inactivation of vitamin D.

A pathway for the metabolism of vitamin D3: unique hydroxylated metabolites formed during catalysis with cytochrome P450scc (CYP11A1).

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1577-1588

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scholarly article

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10.1124/DMD.111.040071

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9

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39

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Andrzej Slominski

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