Association with the auxiliary subunit PEX5R/Trip8b controls responsiveness of HCN channels to cAMP and adrenergic stimulation
about
Mutant GlialCAM causes megalencephalic leukoencephalopathy with subcortical cysts, benign familial macrocephaly, and macrocephaly with retardation and autismCortical HCN channels: function, trafficking and plasticityStructure and stoichiometry of an accessory subunit TRIP8b interaction with hyperpolarization-activated cyclic nucleotide-gated channelsNative GABA(B) receptors are heteromultimers with a family of auxiliary subunitsDifferential expression of HCN subunits alters voltage-dependent gating of h-channels in CA1 pyramidal neurons from dorsal and ventral hippocampusTrafficking and surface expression of hyperpolarization-activated cyclic nucleotide-gated channels in hippocampal neuronsStructures of the Human HCN1 Hyperpolarization-Activated ChannelIdentification of Small-Molecule Inhibitors of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels.Deletion of the hyperpolarization-activated cyclic nucleotide-gated channel auxiliary subunit TRIP8b impairs hippocampal Ih localization and function and promotes antidepressant behavior in mice.Reduction of thalamic and cortical Ih by deletion of TRIP8b produces a mouse model of human absence epilepsy.TRIP8b-independent trafficking and plasticity of adult cortical presynaptic HCN1 channels.Dendritic ion channel trafficking and plasticity.Interaction proteomics of synapse protein complexes.Quantitative proteomics of the Cav2 channel nano-environments in the mammalian brain.Regulation of axonal HCN1 trafficking in perforant path involves expression of specific TRIP8b isoforms.Targeted deletion of Kcne2 impairs HCN channel function in mouse thalamocortical circuits.Structural basis for the mutual antagonism of cAMP and TRIP8b in regulating HCN channel function.More than a pore: ion channel signaling complexesHCN channels in behavior and neurological disease: too hyper or not active enough?Trafficking and gating of hyperpolarization-activated cyclic nucleotide-gated channels are regulated by interaction with tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b) and cyclic AMP at distinct sites.The fast and slow ups and downs of HCN channel regulation.cAMP control of HCN2 channel Mg2+ block reveals loose coupling between the cyclic nucleotide-gating ring and the pore.HCN channelopathies: pathophysiology in genetic epilepsy and therapeutic implicationsExtending the dynamic range of label-free mass spectrometric quantification of affinity purifications.An N-terminal deletion variant of HCN1 in the epileptic WAG/Rij strain modulates HCN current densities.Dorsoventral differences in intrinsic properties in developing CA1 pyramidal cells.Differential dorso-ventral distributions of Kv4.2 and HCN proteins confer distinct integrative properties to hippocampal CA1 pyramidal cell distal dendrites.Effects of acetylcholine on neuronal properties in entorhinal cortex.Neuromodulation of I(h) in layer II medial entorhinal cortex stellate cells: a voltage-clamp study.Cellular context and multiple channel domains determine cAMP sensitivity of HCN4 channels: ligand-independent relief of autoinhibition in HCN4.TRIP8b splice variants form a family of auxiliary subunits that regulate gating and trafficking of HCN channels in the brain.Binding of the auxiliary subunit TRIP8b to HCN channels shifts the mode of action of cAMPShort- and long-term plasticity in CA1 neurons from mice lacking h-channel auxiliary subunit TRIP8b.HCN-channel dendritic targeting requires bipartite interaction with TRIP8b and regulates antidepressant-like behavioral effects.Electrophysiological insights into the enduring effects of early life stress on the brain.Exploring HCN channels as novel drug targets.HCN and KV7 (M-) channels as targets for epilepsy treatment.Clathrin-mediated endocytosis and adaptor proteins.Association of adaptor protein TRIP8b with clathrin.HCN channels--modulators of cardiac and neuronal excitability.
P2860
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P2860
Association with the auxiliary subunit PEX5R/Trip8b controls responsiveness of HCN channels to cAMP and adrenergic stimulation
description
2009 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2009
@ast
im Juni 2009 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2009/06/25)
@sk
vědecký článek publikovaný v roce 2009
@cs
wetenschappelijk artikel (gepubliceerd op 2009/06/25)
@nl
наукова стаття, опублікована в червні 2009
@uk
مقالة علمية (نشرت في 25-6-2009)
@ar
name
Association with the auxiliary ...... AMP and adrenergic stimulation
@ast
Association with the auxiliary ...... AMP and adrenergic stimulation
@en
Association with the auxiliary ...... AMP and adrenergic stimulation
@nl
type
label
Association with the auxiliary ...... AMP and adrenergic stimulation
@ast
Association with the auxiliary ...... AMP and adrenergic stimulation
@en
Association with the auxiliary ...... AMP and adrenergic stimulation
@nl
prefLabel
Association with the auxiliary ...... AMP and adrenergic stimulation
@ast
Association with the auxiliary ...... AMP and adrenergic stimulation
@en
Association with the auxiliary ...... AMP and adrenergic stimulation
@nl
P2093
P50
P3181
P1433
P1476
Association with the auxiliary ...... AMP and adrenergic stimulation
@en
P2093
Alexander Pfeifer
Andreas Hofmann
Andreas Vlachos
Bernd K. Fleischmann
Catrin S. Müller
Daniela Wenzel
Gerd Zolles
Jochen Roeper
Thomas Deller
Uwe Schulte
P304
P3181
P356
10.1016/J.NEURON.2009.05.008
P407
P577
2009-06-25T00:00:00Z