Definition of Munc13-homology-domains and characterization of a novel ubiquitously expressed Munc13 isoform
about
Munc13-4 is an effector of rab27a and controls secretion of lysosomes in hematopoietic cellsThe presynaptic active zoneMunc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosisRIM proteins activate vesicle priming by reversing autoinhibitory homodimerization of Munc13Molecular machines governing exocytosis of synaptic vesiclesRegulation of vesicular trafficking and leukocyte function by Rab27 GTPases and their effectorsMunc13-4 interacts with syntaxin 7 and regulates late endosomal maturation, endosomal signaling, and TLR9-initiated cellular responsesBehavior and Properties of Mature Lytic Granules at the Immunological Synapse of Human Cytotoxic T LymphocytesThe Crystal Structure of a Munc13 C-terminal Module Exhibits a Remarkable Similarity to Vesicle Tethering FactorsMso1 is a novel component of the yeast exocytic SNARE complex.Diacylglycerol Kinases in T Cell Tolerance and Effector FunctionA family of Ca2+-dependent activator proteins for secretion: comparative analysis of structure, expression, localization, and functionAberrant morphology and residual transmitter release at the Munc13-deficient mouse neuromuscular synapseIdentification of a Munc13-sensitive step in chromaffin cell large dense-core vesicle exocytosisCAPS and Munc13 utilize distinct PIP2-linked mechanisms to promote vesicle exocytosisUpregulation of the Rab27a-dependent trafficking and secretory mechanisms improves lysosomal transport, alleviates endoplasmic reticulum stress, and reduces lysosome overload in cystinosis.Munc13-4 Is a Rab11-binding Protein That Regulates Rab11-positive Vesicle Trafficking and Docking at the Plasma Membrane.Synaptic UNC13A protein variant causes increased neurotransmission and dyskinetic movement disorderMunc13-4 functions as a Ca2+ sensor for homotypic secretory granule fusion to generate endosomal exocytic vacuoles.Transcriptional regulation of Munc13-4 expression in cytotoxic lymphocytes is disrupted by an intronic mutation associated with a primary immunodeficiency.BAIAP3, a C2 domain-containing Munc13 protein, controls the fate of dense-core vesicles in neuroendocrine cellsMunc13-4 is a limiting factor in the pathway required for platelet granule release and hemostasis.Novel interactions of CAPS (Ca2+-dependent activator protein for secretion) with the three neuronal SNARE proteins required for vesicle fusion.ORAI1-mediated calcium influx is required for human cytotoxic lymphocyte degranulation and target cell lysisSchizosaccharomyces pombe Git1 is a C2-domain protein required for glucose activation of adenylate cyclase.Phorbol esters and neurotransmitter release: more than just protein kinase C?Munc13-4 reconstitutes calcium-dependent SNARE-mediated membrane fusion.Primary hemophagocytic syndromes point to a direct link between lymphocyte cytotoxicity and homeostasis.CAPS and syntaxin dock dense core vesicles to the plasma membrane in neuronsRegulation of Lipid Signaling by Diacylglycerol Kinases during T Cell Development and FunctionA Munc13-like protein in Arabidopsis mediates H+-ATPase translocation that is essential for stomatal responses.The non-neuronal syntaxin SYN-1 regulates defecation behavior and neural activity in C. elegans through interaction with the Munc13-like protein AEX-1.Genetic markers of a Munc13 protein family member, BAIAP3, are gender specifically associated with anxiety and benzodiazepine abuse in mice and humans.Regulated mucin secretion from airway epithelial cellsCAPS1 stabilizes the state of readily releasable synaptic vesicles to fusion competence at CA3-CA1 synapses in adult hippocampusA network of interactions enables CCM3 and STK24 to coordinate UNC13D-driven vesicle exocytosis in neutrophils.The Vesicle Priming Factor CAPS Functions as a Homodimer via C2 Domain Interactions to Promote Regulated Vesicle Exocytosis.CAPS drives trans-SNARE complex formation and membrane fusion through syntaxin interactionsFamilial hemophagocytic lymphohistiocytosis: when rare diseases shed light on immune system functioning.Role of PI(4,5)P(2) in vesicle exocytosis and membrane fusion.
P2860
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P2860
Definition of Munc13-homology-domains and characterization of a novel ubiquitously expressed Munc13 isoform
description
2000 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2000
@ast
im Juli 2000 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2000/07/01)
@sk
vědecký článek publikovaný v roce 2000
@cs
wetenschappelijk artikel (gepubliceerd op 2000/07/01)
@nl
наукова стаття, опублікована в липні 2000
@uk
مقالة علمية (نشرت في يوليو 2000)
@ar
name
Definition of Munc13-homology- ...... ously expressed Munc13 isoform
@ast
Definition of Munc13-homology- ...... ously expressed Munc13 isoform
@en
Definition of Munc13-homology- ...... ously expressed Munc13 isoform
@nl
type
label
Definition of Munc13-homology- ...... ously expressed Munc13 isoform
@ast
Definition of Munc13-homology- ...... ously expressed Munc13 isoform
@en
Definition of Munc13-homology- ...... ously expressed Munc13 isoform
@nl
prefLabel
Definition of Munc13-homology- ...... ously expressed Munc13 isoform
@ast
Definition of Munc13-homology- ...... ously expressed Munc13 isoform
@en
Definition of Munc13-homology- ...... ously expressed Munc13 isoform
@nl
P2093
P2860
P3181
P1433
P1476
Definition of Munc13-homology- ...... ously expressed Munc13 isoform
@en
P2093
P2860
P304
P3181
P356
10.1042/0264-6021:3490247
P407
P577
2000-07-01T00:00:00Z