Cyclical and alternating infusions of glucose and intralipid in rats inhibit insulin gene expression and Pdx-1 binding in islets.
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Deletion of 12/15-lipoxygenase alters macrophage and islet function in NOD-Alox15(null) mice, leading to protection against type 1 diabetes developmentAn islet in distress: β cell failure in type 2 diabetes.Novel canine models of obese prediabetes and mild type 2 diabetes.Lack of TXNIP protects against mitochondria-mediated apoptosis but not against fatty acid-induced ER stress-mediated beta-cell death.Glucolipotoxicity of the pancreatic beta cell.Lack of preservation of insulin gene expression by a glucagon-like peptide 1 agonist or a dipeptidyl peptidase 4 inhibitor in an in vivo model of glucolipotoxicityGlucolipotoxicity age-dependently impairs beta cell function in rats despite a marked increase in beta cell mass.Lipopolysaccharides impair insulin gene expression in isolated islets of Langerhans via Toll-Like Receptor-4 and NF-κB signalling.Chronic glucolipotoxic conditions in pancreatic islets impair insulin secretion due to dysregulated calcium dynamics, glucose responsiveness and mitochondrial activity.Binding of activating transcription factor 6 to the A5/Core of the rat insulin II gene promoter does not mediate its transcriptional repression.Free fatty acids block glucose-induced β-cell proliferation in mice by inducing cell cycle inhibitors p16 and p18Chronic Exposure to Excess Nutrients Left-shifts the Concentration Dependence of Glucose-stimulated Insulin Secretion in Pancreatic β-CellsPancreatic and duodenal homeobox-1 nuclear localization is regulated by glucose in dispersed rat islets but not in insulin-secreting cell linesIslet Brain 1 Protects Insulin Producing Cells against LipotoxicityDual-Reporter β-Cell-Specific Male Transgenic Rats for the Analysis of β-Cell Functional Mass and Enrichment by Flow Cytometry.The fatty acid receptor GPR40 plays a role in insulin secretion in vivo after high-fat feeding.Pioglitazone acutely reduces energy metabolism and insulin secretion in ratsVascular effects of intravenous intralipid and dextrose infusions in obese subjectsPer-Arnt-Sim kinase regulates pancreatic duodenal homeobox-1 protein stability via phosphorylation of glycogen synthase kinase 3β in pancreatic β-cellsSurvey of the human pancreatic beta-cell G1/S proteome reveals a potential therapeutic role for cdk-6 and cyclin D1 in enhancing human beta-cell replication and function in vivo.Glucolipotoxicity of the pancreatic beta-cell: myth or reality?Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells.A model of chronic nutrient infusion in the rat.Mitochondrial networking protects beta-cells from nutrient-induced apoptosis.Early detection of liver steatosis by magnetic resonance imaging in rats infused with glucose and intralipid solutions and correlation to insulin levels.Pdx1 and other factors that regulate pancreatic beta-cell survival.The P21-activated kinase PAK4 is implicated in fatty-acid potentiation of insulin secretion downstream of free fatty acid receptor 1.20-HETE attenuates the response of glucose-stimulated insulin secretion through the AKT/GSK-3β/Glut2 pathway.Inhibition of cholinergic potentiation of insulin secretion from pancreatic islets by chronic elevation of glucose and fatty acids: Protection by casein kinase 2 inhibitor.Saturated free fatty acids: islet β cell "stressERs".Hexane Extract of Orthosiphon stamineus Induces Insulin Expression and Prevents Glucotoxicity in INS-1 Cells.Effect of plasma free fatty acid supply on the rate of ceramide synthesis in different muscle types in the rat.Glucose and fatty acids synergistically and reversibly promote beta cell proliferation in rats.Effects of supplementation with omega-3 on insulin sensitivity and non-esterified free fatty acid (NEFA) in type 2 diabetic patients
P2860
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P2860
Cyclical and alternating infusions of glucose and intralipid in rats inhibit insulin gene expression and Pdx-1 binding in islets.
description
2007 nî lūn-bûn
@nan
2007 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Cyclical and alternating infus ...... on and Pdx-1 binding in islets
@nl
Cyclical and alternating infus ...... n and Pdx-1 binding in islets.
@ast
Cyclical and alternating infus ...... n and Pdx-1 binding in islets.
@en
type
label
Cyclical and alternating infus ...... on and Pdx-1 binding in islets
@nl
Cyclical and alternating infus ...... n and Pdx-1 binding in islets.
@ast
Cyclical and alternating infus ...... n and Pdx-1 binding in islets.
@en
prefLabel
Cyclical and alternating infus ...... on and Pdx-1 binding in islets
@nl
Cyclical and alternating infus ...... n and Pdx-1 binding in islets.
@ast
Cyclical and alternating infus ...... n and Pdx-1 binding in islets.
@en
P2093
P2860
P356
P1433
P1476
Cyclical and alternating infus ...... on and Pdx-1 binding in islets
@en
P2093
Caroline Tremblay
Derek K Hagman
Ghislaine Fontes
James A Lausier
Julie Amyot
Martin G Latour
Meriem Semache
Raghavendra G Mirmira
Swarup K Chakrabarti
Thomas L Jetton
P2860
P304
P356
10.2337/DB07-1285
P407
P577
2007-11-08T00:00:00Z