Glucolipotoxicity age-dependently impairs beta cell function in rats despite a marked increase in beta cell mass. - Wikidata - awgldk - TriplyDB

Glucolipotoxicity age-dependently impairs beta cell function in rats despite a marked increase in beta cell mass.

Glucolipotoxicity age-dependently impairs beta cell function in rats despite a marked increase in beta cell mass.

http://www.wikidata.org/entity/Q34163947

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Report from IPITA-TTS Opinion Leaders Meeting on the Future of β-Cell Replacement The role of mammalian sirtuins in the regulation of metabolism, aging, and longevity Lipotoxicity in the pancreatic beta cell: not just survival and function, but proliferation as well?Environmental Contaminants and Pancreatic Beta-Cells Islet biology, the CDKN2A/B locus and type 2 diabetes risk.Ongoing beta-cell turnover in adult nonhuman primates is not adaptively increased in streptozotocin-induced diabetes Pancreatic β-Cell Adaptive Plasticity in Obesity Increases Insulin Production but Adversely Affects Secretory Function.Human β-cell regeneration: progress, hurdles, and controversy.Palmitate induces mRNA translation and increases ER protein load in islet β-cells via activation of the mammalian target of rapamycin pathway Unraveling the contribution of pancreatic beta-cell suicide in autoimmune type 1 diabetes.ChREBP mediates glucose repression of peroxisome proliferator-activated receptor alpha expression in pancreatic beta-cells.Deoxyhypusine synthase haploinsufficiency attenuates acute cytokine signaling.Mechanistic insights into pancreatic beta-cell mass regulation by glucose and free fatty acids.High-fat diet-induced β-cell proliferation occurs prior to insulin resistance in C57Bl/6J male mice.Free fatty acids block glucose-induced β-cell proliferation in mice by inducing cell cycle inhibitors p16 and p18 How does type 1 diabetes develop?: the notion of homicide or β-cell suicide revisited.Insulin demand regulates β cell number via the unfolded protein response.Dual-Reporter β-Cell-Specific Male Transgenic Rats for the Analysis of β-Cell Functional Mass and Enrichment by Flow Cytometry.Islet β cell mass in diabetes and how it relates to function, birth, and death.Translational control of inducible nitric oxide synthase by p38 MAPK in islet β-cells Npas4 is a novel activity-regulated cytoprotective factor in pancreatic β-cells.Adaptive β-cell proliferation increases early in high-fat feeding in mice, concurrent with metabolic changes, with induction of islet cyclin D2 expression.Urea impairs β cell glycolysis and insulin secretion in chronic kidney disease.The regulator of G-protein signaling RGS16 promotes insulin secretion and β-cell proliferation in rodent and human islets.A model of chronic nutrient infusion in the rat.The islet estrogen receptor-α is induced by hyperglycemia and protects against oxidative stress-induced insulin-deficient diabetes.Early detection of liver steatosis by magnetic resonance imaging in rats infused with glucose and intralipid solutions and correlation to insulin levels.Long- but not short-term adult-onset, isolated GH deficiency in male mice leads to deterioration of β-cell function, which cannot be accounted for by changes in β-cell mass.Epidermal growth factor receptor signaling promotes pancreatic β-cell proliferation in response to nutrient excess in rats through mTOR and FOXM1.Treatment of type 2 diabetes by free Fatty Acid receptor agonists.GPR40 agonists for the treatment of type 2 diabetes: life after 'TAKing' a hit.The Role and Future of FFA1 as a Therapeutic Target.Delta cell death in the islet of Langerhans and the progression from normal glucose tolerance to type 2 diabetes in non-human primates (baboon, Papio hamadryas).Islet inflammation and ductal proliferation may be linked to increased pancreatitis risk in type 2 diabetes Nutrient regulation of pancreatic β-cell proliferation.G protein-coupled receptor (GPR)40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1.β-cell metabolic alterations under chronic nutrient overload in rat and human islets.Considerations and guidelines for mouse metabolic phenotyping in diabetes research.IKKβ inhibition prevents fat-induced beta cell dysfunction in vitro and in vivo in rodents.Fatty Acids, Antioxidants and Physical Activity in Brain Aging.

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P2860

Glucolipotoxicity age-dependently impairs beta cell function in rats despite a marked increase in beta cell mass.

http://www.wikidata.org/entity/Q34163947

description

2010 nî lūn-bûn

@nan

2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հուլիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Glucolipotoxicity age-dependen ...... ed increase in beta cell mass.

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Glucolipotoxicity age-dependen ...... ed increase in beta cell mass.

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Glucolipotoxicity age-dependen ...... ed increase in beta cell mass.

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Glucolipotoxicity age-dependen ...... ed increase in beta cell mass.

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Glucolipotoxicity age-dependen ...... ed increase in beta cell mass.

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Glucolipotoxicity age-dependen ...... ed increase in beta cell mass.

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Glucolipotoxicity age-dependen ...... ed increase in beta cell mass.

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P2860

Lipotoxicity of the pancreatic beta-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids

Increasing triglyceride synthesis inhibits glucose-induced insulin secretion in isolated rat islets of langerhans: a study using adenoviral expression of diacylglycerol acyltransferase

Cyclical and alternating infusions of glucose and intralipid in rats inhibit insulin gene expression and Pdx-1 binding in islets.

Lipid infusion lowers sympathetic nervous activity and leads to increased beta-cell responsiveness to glucose.

Minireview: Secondary beta-cell failure in type 2 diabetes--a convergence of glucotoxicity and lipotoxicity.

Effects of hemipancreatectomy on pancreatic alpha and beta cell function in healthy human donors.

Palmitate inhibits insulin gene expression by altering PDX-1 nuclear localization and reducing MafA expression in isolated rat islets of Langerhans.

Islet beta cell failure in type 2 diabetes

Age-dependent decline in beta-cell proliferation restricts the capacity of beta-cell regeneration in mice.

Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes.

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