about
Glucose activates free fatty acid receptor 1 gene transcription via phosphatidylinositol-3-kinase-dependent O-GlcNAcylation of pancreas-duodenum homeobox-1Pioglitazone acutely reduces insulin secretion and causes metabolic deceleration of the pancreatic beta-cell at submaximal glucose concentrationsGPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo.An Acetate-Specific GPCR, FFAR2, Regulates Insulin SecretionProinsulin processing in the diabetic Goto-Kakizaki ratElevated glucose attenuates human insulin gene promoter activity in INS-1 pancreatic beta-cells via reduced nuclear factor binding to the A5/core and Z elementCyclical and alternating infusions of glucose and intralipid in rats inhibit insulin gene expression and Pdx-1 binding in islets.Prostaglandin E(2) mediates inhibition of insulin secretion by interleukin-1betaCharacterization of the human pancreatic islet proteome by two-dimensional LC/MS/MSLack of TXNIP protects against mitochondria-mediated apoptosis but not against fatty acid-induced ER stress-mediated beta-cell death.Glucolipotoxicity of the pancreatic beta cell.Lack of preservation of insulin gene expression by a glucagon-like peptide 1 agonist or a dipeptidyl peptidase 4 inhibitor in an in vivo model of glucolipotoxicityLipopolysaccharides impair insulin gene expression in isolated islets of Langerhans via Toll-Like Receptor-4 and NF-κB signalling.Binding of activating transcription factor 6 to the A5/Core of the rat insulin II gene promoter does not mediate its transcriptional repression.High-fat diet-induced β-cell proliferation occurs prior to insulin resistance in C57Bl/6J male mice.Human mutation within Per-Arnt-Sim (PAS) domain-containing protein kinase (PASK) causes basal insulin hypersecretion.G protein-coupled receptors and insulin secretion: 119 and countingDiscovery of novel glucose-regulated proteins in isolated human pancreatic islets using LC-MS/MS-based proteomics.Pancreatic and duodenal homeobox-1 nuclear localization is regulated by glucose in dispersed rat islets but not in insulin-secreting cell linesPhenotypic Characterization of MIP-CreERT1Lphi Mice With Transgene-Driven Islet Expression of Human Growth HormonePGC-1 coactivators in β-cells regulate lipid metabolism and are essential for insulin secretion coupled to fatty acidsDual-Reporter β-Cell-Specific Male Transgenic Rats for the Analysis of β-Cell Functional Mass and Enrichment by Flow Cytometry.The free fatty acid receptor G protein-coupled receptor 40 (GPR40) protects from bone loss through inhibition of osteoclast differentiation.The fatty acid receptor GPR40 plays a role in insulin secretion in vivo after high-fat feeding.Glucolipotoxicity: fuel excess and beta-cell dysfunction.Pioglitazone acutely reduces energy metabolism and insulin secretion in ratsThe ΔF508 Mutation in the Cystic Fibrosis Transmembrane Conductance Regulator Is Associated With Progressive Insulin Resistance and Decreased Functional β-Cell Mass in Mice.Npas4 is a novel activity-regulated cytoprotective factor in pancreatic β-cells.GPR40: good cop, bad cop?Urea impairs β cell glycolysis and insulin secretion in chronic kidney disease.Glucolipotoxicity of the pancreatic beta-cell: myth or reality?The regulator of G-protein signaling RGS16 promotes insulin secretion and β-cell proliferation in rodent and human islets.Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells.Deletion of GPR40 impairs glucose-induced insulin secretion in vivo in mice without affecting intracellular fuel metabolism in islets.The islet estrogen receptor-α is induced by hyperglycemia and protects against oxidative stress-induced insulin-deficient diabetes.Early detection of liver steatosis by magnetic resonance imaging in rats infused with glucose and intralipid solutions and correlation to insulin levels.Epidermal growth factor receptor signaling promotes pancreatic β-cell proliferation in response to nutrient excess in rats through mTOR and FOXM1.Modulating GPR40: therapeutic promise and potential in diabetes.GPR40 agonists for the treatment of type 2 diabetes: life after 'TAKing' a hit.β-Arrestin Recruitment and Biased Agonism at Free Fatty Acid Receptor 1.
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hulumtues
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Vincent Poitout
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Vincent Poitout
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Vincent Poitout
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Vincent Poitout
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Vincent Poitout
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Vincent Poitout
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Vincent Poitout
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Vincent Poitout
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Vincent Poitout
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Vincent Poitout
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Vincent Poitout
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P106
P1153
7003998583
P2002
P21
P31
P496
0000-0002-6555-5053