Early embryonic lethality caused by targeted disruption of the 3-hydroxy-3-methylglutaryl-CoA reductase gene
about
Recent insights into the Smith-Lemli-Opitz syndrome.To Extinguish the Fire from Outside the Cell or to Shutdown the Gas Valve Inside? Novel Trends in Anti-Inflammatory TherapiesHidden disease susceptibility and sexual dimorphism in the heterozygous knockout of Cyp51 from cholesterol synthesisCholesterol metabolism is required for intracellular hedgehog signal transduction in vivoIncreased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liverInhibition of HMG CoA reductase reveals an unexpected role for cholesterol during PGC migration in the mouse.Survival of adult neurons lacking cholesterol synthesis in vivo.Functional analysis of the zebrafish ortholog of HMGCS1 reveals independent functions for cholesterol and isoprenoids in craniofacial development.Disruption of the gene encoding 3beta-hydroxysterol Delta-reductase (Tm7sf2) in mice does not impair cholesterol biosynthesis.The use of the Dhcr7 knockout mouse to accurately determine the origin of fetal sterols.Mouse knockout of the cholesterogenic cytochrome P450 lanosterol 14alpha-demethylase (Cyp51) resembles Antley-Bixler syndromeThe mevalonate pathway regulates primitive streak formation via protein farnesylationEffects of perilipin 2 antisense oligonucleotide treatment on hepatic lipid metabolism and gene expressionDefects of cholesterol biosynthesis.Statins inhibit blastocyst formation by preventing geranylgeranylation.Prolactin receptor-associated protein/17beta-hydroxysteroid dehydrogenase type 7 gene (Hsd17b7) plays a crucial role in embryonic development and fetal survival.3-Hydroxymethyl coenzyme A reductase inhibition attenuates spontaneous smooth muscle tone via RhoA/ROCK pathway regulated by RhoA prenylationABCA1 plays no role in the centripetal movement of cholesterol from peripheral tissues to the liver and intestine in the mouseDevelopmental expression pattern of the cholesterogenic enzyme NSDHL and negative selection of NSDHL-deficient cells in the heterozygous Bpa(1H)/+ mouse.Defects in cholesterol synthesis genes in mouse and in humans: lessons for drug development and safer treatments.Cholesterol: a novel regulatory role in myelin formation.Mevalonate kinase deficiency and neuroinflammation: balance between apoptosis and pyroptosis.Reduction in cholesterol synthesis in response to serum starvation in lymphoblasts of a patient with Barth syndrome.Cardiolipin synthesis is required to support human cholesterol biosynthesis from palmitate upon serum removal in Hela cells.Cholesterol auxotrophy and intolerance to ezetimibe in mice with SREBP-2 deficiency in the intestine.Functional characterization of AMP-activated protein kinase signaling in tumorigenesis.Using human genetics to discover new therapeutic targets for plasma lipids.HMG-CoA reductase inhibitors activate the unfolded protein response and induce cytoprotective GRP78 expression.Liver and the defects of cholesterol and bile acids biosynthesis: Rare disorders many diagnostic pitfalls.Embryotoxicant-specific transcriptomic responses in rat postimplantation whole-embryo culture.Inhibition of the 3-hydroxy-3-methyl-glutaryl-CoA reductase induces orofacial defects in zebrafish.
P2860
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P2860
Early embryonic lethality caused by targeted disruption of the 3-hydroxy-3-methylglutaryl-CoA reductase gene
description
2003 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2003
@ast
im August 2003 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2003/10/31)
@sk
vědecký článek publikovaný v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/10/31)
@nl
наукова стаття, опублікована в жовтні 2003
@uk
name
Early embryonic lethality caus ...... hylglutaryl-CoA reductase gene
@ast
Early embryonic lethality caus ...... hylglutaryl-CoA reductase gene
@en
Early embryonic lethality caus ...... hylglutaryl-CoA reductase gene
@nl
type
label
Early embryonic lethality caus ...... hylglutaryl-CoA reductase gene
@ast
Early embryonic lethality caus ...... hylglutaryl-CoA reductase gene
@en
Early embryonic lethality caus ...... hylglutaryl-CoA reductase gene
@nl
prefLabel
Early embryonic lethality caus ...... hylglutaryl-CoA reductase gene
@ast
Early embryonic lethality caus ...... hylglutaryl-CoA reductase gene
@en
Early embryonic lethality caus ...... hylglutaryl-CoA reductase gene
@nl
P2093
P356
P1476
Early embryonic lethality caus ...... hylglutaryl-CoA reductase gene
@en
P2093
Hiroaki Okazaki
Hiroaki Yagyu
Hitoshi Shimano
Jun-ichi Osuga
Ken Ohashi
Kenji Harada
Motohiro Sekiya
Nobuhiro Yamada
Ryuichi Tozawa
Sachiko Tomita
P304
42936-42941
P356
10.1074/JBC.M307228200
P407
P50
P577
2003-08-14T00:00:00Z