FRIP, a hematopoietic cell-specific rasGAP-interacting protein phosphorylated in response to cytokine stimulation
about
Evidence that Llck-mediated phosphorylation of p56dok and p62dok may play a role in CD2 signalingp56(dok-2) as a cytokine-inducible inhibitor of cell proliferation and signal transductionT cell regulation of p62(dok) (Dok1) association with Crk-LDok-R mediates attenuation of epidermal growth factor-dependent mitogen-activated protein kinase and Akt activation through processive recruitment of c-Src and Csk.Tyrosine phosphorylation of p62(Dok) induced by cell adhesion and insulin: possible role in cell migrationDok-R plays a pivotal role in angiopoietin-1-dependent cell migration through recruitment and activation of Pak.Dok-3, a novel adapter molecule involved in the negative regulation of immunoreceptor signalingCharacterization of a novel member of the DOK family that binds and modulates Abl signalingThe X-linked lymphoproliferative syndrome gene product SH2D1A associates with p62dok (Dok1) and activates NF-kappa BA unique autophosphorylation site on Tie2/Tek mediates Dok-R phosphotyrosine binding domain binding and functionNovel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiationA mouse homologue of the Drosophila tumor suppressor l(2)tid gene defines a novel Ras GTPase-activating protein (RasGAP)-binding proteinDocking protein Gab2 is phosphorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory moleculesDok-R binds c-Abl and regulates Abl kinase activity and mediates cytoskeletal reorganizationCoupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responsesp62(dok), a negative regulator of Ras and mitogen-activated protein kinase (MAPK) activity, opposes leukemogenesis by p210(bcr-abl)Independent SH2-binding sites mediate interaction of Dok-related protein with RasGTPase-activating protein and NckDomain-dependent function of the rasGAP-binding protein p62Dok in cell signaling.DOK4 and DOK5: new Dok-related genes expressed in human T cells.Stat6 and IRS-2 cooperate in interleukin 4 (IL-4)-induced proliferation and differentiation but are dispensable for IL-4-dependent rescue from apoptosis.Oncogenic tyrosine kinases target Dok-1 for ubiquitin-mediated proteasomal degradation to promote cell transformationRole of the rasGAP-associated docking protein p62(dok) in negative regulation of B cell receptor-mediated signaling.The interleukin (IL)-2 family cytokines: survival and proliferation signaling pathways in T lymphocytes.The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase LynT cell receptor for antigen induces linker for activation of T cell-dependent activation of a negative signaling complex involving Dok-2, SHIP-1, and Grb-2Dok-related protein negatively regulates T cell development via its RasGTPase-activating protein and Nck docking sitesPhosphoinositide 3-kinase-dependent membrane recruitment of p62(dok) is essential for its negative effect on mitogen-activated protein (MAP) kinase activation.Targeted inactivation of the IL-4 receptor alpha chain I4R motif promotes allergic airway inflammation.Transient inhibition of interleukin 4 signaling by T cell receptor ligation.Role of Dok-1 and Dok-2 in leukemia suppression.IkappaB kinase beta phosphorylates Dok1 serines in response to TNF, IL-1, or gamma radiation.Inhibition of the motility and growth of B16F10 mouse melanoma cells by dominant negative mutants of Dok-1.Pleckstrin homology and phosphotyrosine-binding domain-dependent membrane association and tyrosine phosphorylation of Dok-4, an inhibitory adapter molecule expressed in epithelial cells.Insulin receptor-mediated p62dok tyrosine phosphorylation at residues 362 and 398 plays distinct roles for binding GTPase-activating protein and Nck and is essential for inhibiting insulin-stimulated activation of Ras and Akt.Multiple ErbB-2/Neu Phosphorylation Sites Mediate Transformation through Distinct Effector Proteins.Positive regulation of interleukin-4-mediated proliferation by the SH2-containing inositol-5'-phosphatase.A nuclear export signal and phosphorylation regulate Dok1 subcellular localization and functionsRole of Dok-1 and Dok-2 in myeloid homeostasis and suppression of leukemia.Development of colitis in signal transducers and activators of transcription 6-deficient T-cell receptor alpha-deficient mice: a potential role of signal transducers and activators of transcription 6-independent interleukin-4 signaling for the generDok-1 independently attenuates Ras/mitogen-activated protein kinase and Src/c-myc pathways to inhibit platelet-derived growth factor-induced mitogenesis.
P2860
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P2860
FRIP, a hematopoietic cell-specific rasGAP-interacting protein phosphorylated in response to cytokine stimulation
description
1998 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1998
@ast
im Juli 1998 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1998/07/01)
@sk
vědecký článek publikovaný v roce 1998
@cs
wetenschappelijk artikel (gepubliceerd op 1998/07/01)
@nl
наукова стаття, опублікована в липні 1998
@uk
مقالة علمية (نشرت في يوليو 1998)
@ar
name
FRIP, a hematopoietic cell-spe ...... sponse to cytokine stimulation
@ast
FRIP, a hematopoietic cell-spe ...... sponse to cytokine stimulation
@en
FRIP, a hematopoietic cell-spe ...... sponse to cytokine stimulation
@nl
type
label
FRIP, a hematopoietic cell-spe ...... sponse to cytokine stimulation
@ast
FRIP, a hematopoietic cell-spe ...... sponse to cytokine stimulation
@en
FRIP, a hematopoietic cell-spe ...... sponse to cytokine stimulation
@nl
prefLabel
FRIP, a hematopoietic cell-spe ...... sponse to cytokine stimulation
@ast
FRIP, a hematopoietic cell-spe ...... sponse to cytokine stimulation
@en
FRIP, a hematopoietic cell-spe ...... sponse to cytokine stimulation
@nl
P2093
P921
P1433
P1476
FRIP, a hematopoietic cell-spe ...... sponse to cytokine stimulation
@en
P2093
P356
10.1016/S1074-7613(00)80584-1
P407
P577
1998-07-01T00:00:00Z