Leucine-rich repeat kinase 2 associates with lipid rafts
about
GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic miceMKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagyLeucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi exportLRRK2 transport is regulated by its novel interacting partner Rab32LRRK2 expression in idiopathic and G2019S positive Parkinson's disease subjects: a morphological and quantitative studyFunctional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamilyMembrane localization of LRRK2 is associated with increased formation of the highly active LRRK2 dimer and changes in its phosphorylationG2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarizationRole of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cellsIntrabody and Parkinson's diseaseLRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular modelThe role of the LRRK2 gene in ParkinsonismProtein Kinases and Parkinson's DiseaseEnhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019SDynamic and redundant regulation of LRRK2 and LRRK1 expression.GTPase activity plays a key role in the pathobiology of LRRK2.Behavioral Phenotyping and Pathological Indicators of Parkinson's Disease in C. elegans Models.Leucine-rich repeat kinase 2 (LRRK2): a key player in the pathogenesis of Parkinson's diseaseMembrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy.Lrrk2 localization in the primate basal ganglia and thalamus: a light and electron microscopic analysis in monkeysRole of LRRK2 kinase dysfunction in Parkinson diseaseLeucine-rich repeat kinase 2 for beginners: six key questions.LRRK2 function on actin and microtubule dynamics in Parkinson diseaseA QUICK screen for Lrrk2 interaction partners--leucine-rich repeat kinase 2 is involved in actin cytoskeleton dynamics.The genetics of Parkinson disease.Novel ethyl methanesulfonate (EMS)-induced null alleles of the Drosophila homolog of LRRK2 reveal a crucial role in endolysosomal functions and autophagy in vivo.Expression analysis of Lrrk1, Lrrk2 and Lrrk2 splice variants in mice.LRRK2 localizes to endosomes and interacts with clathrin-light chains to limit Rac1 activation.LRRK2 affects vesicle trafficking, neurotransmitter extracellular level and membrane receptor localization.The Parkinson's disease protein LRRK2 impairs proteasome substrate clearance without affecting proteasome catalytic activity.Transcriptional responses to loss or gain of function of the leucine-rich repeat kinase 2 (LRRK2) gene uncover biological processes modulated by LRRK2 activity.Roles of the Drosophila LRRK2 homolog in Rab7-dependent lysosomal positioningEvolution of neurodegeneration.Loss of parkin promotes lipid rafts-dependent endocytosis through accumulating caveolin-1: implications for Parkinson's diseaseA randomized, controlled, delayed start trial of GM1 ganglioside in treated Parkinson's disease patients.LRRK2: an éminence grise of Wnt-mediated neurogenesis?Molecular pathways and genetic aspects of Parkinson's disease: from bench to bedside.Kinase signaling pathways as potential targets in the treatment of Parkinson's disease.
P2860
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P2860
Leucine-rich repeat kinase 2 associates with lipid rafts
description
2007 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մարտին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2007
@ast
im März 2007 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2007/03/15)
@sk
vědecký článek publikovaný v roce 2007
@cs
wetenschappelijk artikel (gepubliceerd op 2007/03/15)
@nl
наукова стаття, опублікована в березні 2007
@uk
مقالة علمية (نشرت في 15-3-2007)
@ar
name
Leucine-rich repeat kinase 2 associates with lipid rafts
@ast
Leucine-rich repeat kinase 2 associates with lipid rafts
@en
Leucine-rich repeat kinase 2 associates with lipid rafts
@nl
type
label
Leucine-rich repeat kinase 2 associates with lipid rafts
@ast
Leucine-rich repeat kinase 2 associates with lipid rafts
@en
Leucine-rich repeat kinase 2 associates with lipid rafts
@nl
prefLabel
Leucine-rich repeat kinase 2 associates with lipid rafts
@ast
Leucine-rich repeat kinase 2 associates with lipid rafts
@en
Leucine-rich repeat kinase 2 associates with lipid rafts
@nl
P2093
P921
P3181
P356
P1476
Leucine-rich repeat kinase 2 associates with lipid rafts
@en
P2093
Kiyoshi Ishikawa
Masahiro Maeda
Satoshi Imai
Shin-Ichiro Kubo
Taku Hatano
P304
P3181
P356
10.1093/HMG/DDM013
P577
2007-03-15T00:00:00Z