APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development
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Deficiency of Aph1B/C-gamma-secretase disturbs Nrg1 cleavage and sensorimotor gating that can be reversed with antipsychotic treatment.Proteolytic processing of Alzheimer's β-amyloid precursor proteinPen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1Γ-secretase components as predictors of breast cancer outcomeCross-species genome wide expression analysis during pluripotent cell determination in mouse and rat preimplantation embryosPresenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expressionGamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrinDeletion of the γ-secretase subunits Aph1B/C impairs memory and worsens the deficits of knock-in mice modeling the Alzheimer-like familial Danish dementiaModeling an anti-amyloid combination therapy for Alzheimer's disease.Assembly, maturation, and trafficking of the gamma-secretase complex in Alzheimer's disease.gamma-Secretase dependent production of intracellular domains is reduced in adult compared to embryonic rat brain membranesDissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases.The secretases: enzymes with therapeutic potential in Alzheimer disease.Characterization of an atypical gamma-secretase complex from hematopoietic originAllosteric regulation of γ-secretase activity by a phenylimidazole-type γ-secretase modulator.Specific domains in anterior pharynx-defective 1 determine its intramembrane interactions with nicastrin and presenilin.Activity-dependent alpha-cleavage of nectin-1 is mediated by a disintegrin and metalloprotease 10 (ADAM10).Inhibition of BACE1 for therapeutic use in Alzheimer's disease.Increased expression of PS1 is sufficient to elevate the level and activity of γ-secretase in vivo.Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process.Transcriptional regulation of PEN-2, a key component of the gamma-secretase complex, by CREBEvidence that CD147 modulation of beta-amyloid (Abeta) levels is mediated by extracellular degradation of secreted AbetaThe γ-secretase complex: from structure to function.Functional and topological analysis of Pen-2, the fourth subunit of the gamma-secretase complex.An overview of notch signaling in adult tissue renewal and maintenance.Presenilins and γ-secretase: structure, function, and role in Alzheimer Disease.Protease inhibitors as potential disease-modifying therapeutics for Alzheimer's disease.Pen-2 is dispensable for endoproteolysis of presenilin 1, and nicastrin-Aph subcomplex is important for both γ-secretase assembly and substrate recruitmentThe role of presenilin and its interacting proteins in the biogenesis of Alzheimer's beta amyloidStructural and Functional Determinants of gamma-Secretase, an Intramembrane Protease Implicated in Alzheimer's Disease.Presenilins: members of the gamma-secretase quartets, but part-time soloists too.APH1 polar transmembrane residues regulate the assembly and activity of presenilin complexesgamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease.The structure and function of Alzheimer's gamma secretase enzyme complex.Proteolytic cleavage of Notch: "HIT and RUN".Assembly of the presenilin γ-/ε-secretase complex.Advances in the identification of γ-secretase inhibitors for the treatment of Alzheimer's disease.The very many faces of presenilins and the γ-secretase complex.Physiological and pathological roles of the γ-secretase complex.Epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of gamma-secretase.
P2860
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P248
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P2860
APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development
description
2005 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2005
@ast
im Januar 2005 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2005/01/05)
@sk
vědecký článek publikovaný v roce 2005
@cs
wetenschappelijk artikel (gepubliceerd op 2005/01/05)
@nl
наукова стаття, опублікована в січні 2005
@uk
مقالة علمية (نشرت في 5-1-2005)
@ar
name
APH-1a is the principal mammal ...... s during embryonic development
@ast
APH-1a is the principal mammal ...... s during embryonic development
@en
APH-1a is the principal mammal ...... s during embryonic development
@nl
type
label
APH-1a is the principal mammal ...... s during embryonic development
@ast
APH-1a is the principal mammal ...... s during embryonic development
@en
APH-1a is the principal mammal ...... s during embryonic development
@nl
prefLabel
APH-1a is the principal mammal ...... s during embryonic development
@ast
APH-1a is the principal mammal ...... s during embryonic development
@en
APH-1a is the principal mammal ...... s during embryonic development
@nl
P2093
P921
P1476
APH-1a is the principal mammal ...... s during embryonic development
@en
P2093
Donald L Price
Philip C Wong
P304
P356
10.1523/JNEUROSCI.3814-04.2005
P407
P577
2005-01-01T00:00:00Z