The Tec kinases Itk and Rlk regulate NKT cell maturation, cytokine production, and survival
about
Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domainThe BTB-zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functionsAntitumor Responses of Invariant Natural Killer T CellsDiscovery of Novel Irreversible Inhibitors of Interleukin (IL)-2-inducible Tyrosine Kinase (Itk) by Targeting Cysteine 442 in the ATP PocketTargets for Ibrutinib Beyond B Cell MalignanciesThe transcription factor c-Myb primes CD4+CD8+ immature thymocytes for selection into the iNKT lineage.ITK tunes IL-4-induced development of innate memory CD8+ T cells in a γδ T and invariant NKT cell-independent manner.Krüppel-like factor 2 regulates trafficking and homeostasis of gammadelta T cellsThe Ras/MAPK pathway is required for generation of iNKT cells.T-cell signaling regulated by the Tec family kinase, Itk.Development of innate CD4+ and CD8+ T cells in Itk-deficient mice is regulated by distinct pathwaysDifferential roles of IL-2-inducible T cell kinase-mediated TCR signals in tissue-specific localization and maintenance of skin intraepithelial T cells.Invariant NKT cell development requires a full complement of functional CD3 zeta immunoreceptor tyrosine-based activation motifsCharacterisation of a K390R ITK kinase dead transgenic mouse--implications for ITK as a therapeutic target.Transcriptional control of invariant NKT cell development.Interleukin-2-inducible T-cell kinase (ITK) deficiency - clinical and molecular aspects.Interleukin-2-inducible T cell kinase (Itk) network edge dependence for the maturation of iNKT cell.Characterization of a novel interaction between transcription factor TFII-I and the inducible tyrosine kinase in T cells.IL-2-inducible T-cell kinase deficiency: clinical presentation and therapeutic approach.Immunodeficiency and immune dysregulation associated with proximal defects of T cell receptor signaling.The tyrosine kinase Itk suppresses CD8+ memory T cell development in response to bacterial infection.Itk signals promote neuroinflammation by regulating CD4+ T-cell activation and trafficking.Itk: the rheostat of the T cell response.The signaling symphony: T cell receptor tunes cytokine-mediated T cell differentiationIL-2-inducible T cell kinase tunes T regulatory cell development and is required for suppressive functionTargeting interleukin-2-inducible T-cell kinase (ITK) and resting lymphocyte kinase (RLK) using a novel covalent inhibitor PRN694.Reduced MCMV Δm157 viral clearance in the absence of TSAd.Regulated Expression of miR-155 is Required for iNKT Cell DevelopmentEssential role of Mediator subunit Med1 in invariant natural killer T-cell developmentA unique role for ITK in survival of invariant NKT cells associated with the p53-dependent pathway in mice.Development of promyelocytic leukemia zinc finger-expressing innate CD4 T cells requires stronger T-cell receptor signals than conventional CD4 T cells.Hiding lipid presentation: viral interference with CD1d-restricted invariant natural killer T (iNKT) cell activationCD8α+ dendritic cell trans presentation of IL-15 to naive CD8+ T cells produces antigen-inexperienced T cells in the periphery with memory phenotype and function.The Tec kinase ITK regulates thymic expansion, emigration, and maturation of γδ NKT cellsThe genetic basis of severe combined immunodeficiency and its variants.The transcriptional regulator PLZF induces the development of CD44 high memory phenotype T cellsThe Tec kinases Itk and Rlk regulate conventional versus innate T-cell development.Girls homozygous for an IL-2-inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation.Tec kinases regulate T-lymphocyte development and function: new insights into the roles of Itk and Rlk/TxkTec kinase Itk in gammadeltaT cells is pivotal for controlling IgE production in vivo.
P2860
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P2860
The Tec kinases Itk and Rlk regulate NKT cell maturation, cytokine production, and survival
description
2008 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մարտին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2008
@ast
im März 2008 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2008/03/01)
@sk
vědecký článek publikovaný v roce 2008
@cs
wetenschappelijk artikel (gepubliceerd op 2008/03/01)
@nl
наукова стаття, опублікована в березні 2008
@uk
مقالة علمية (نشرت في مارس 2008)
@ar
name
The Tec kinases Itk and Rlk re ...... okine production, and survival
@ast
The Tec kinases Itk and Rlk re ...... okine production, and survival
@en
The Tec kinases Itk and Rlk re ...... okine production, and survival
@nl
type
label
The Tec kinases Itk and Rlk re ...... okine production, and survival
@ast
The Tec kinases Itk and Rlk re ...... okine production, and survival
@en
The Tec kinases Itk and Rlk re ...... okine production, and survival
@nl
prefLabel
The Tec kinases Itk and Rlk re ...... okine production, and survival
@ast
The Tec kinases Itk and Rlk re ...... okine production, and survival
@en
The Tec kinases Itk and Rlk re ...... okine production, and survival
@nl
P1476
The Tec kinases Itk and Rlk re ...... okine production, and survival
@en
P2093
Leslie J. Berg
Martin Felices
P304
P356
10.4049/JIMMUNOL.180.5.3007
P407
P577
2008-03-01T00:00:00Z