Novel splicing isoforms of synaptotagmin-like proteins 2 and 3: identification of the Slp homology domain
about
MyRIP anchors protein kinase A to the exocyst complexA family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transportSlp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapseMutations in Mlph, encoding a member of the Rab effector family, cause the melanosome transport defects observed in leaden miceSlac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transportDistinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cellsThe Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domainThe N-terminal cysteine cluster is essential for membrane targeting of B/K proteinThe leaden gene product is required with Rab27a to recruit myosin Va to melanosomes in melanocytesRabphilin and Noc2 are recruited to dense-core vesicles through specific interaction with Rab27A in PC12 cellsThe C2B domain of rabphilin directly interacts with SNAP-25 and regulates the docking step of dense core vesicle exocytosis in PC12 cellsSlac2-c (synaptotagmin-like protein homologue lacking C2 domains-c), a novel linker protein that interacts with Rab27, myosin Va/VIIa, and actinTac2-N, an atypical C-type tandem C2 protein localized in the nucleusThe Drosophila synaptotagmin-like protein bitesize is required for growth and has mRNA localization sequences within its open reading frame.High-precision mapping of protein protein interfaces: an integrated genetic strategy combining en masse mutagenesis and DNA-level parallel analysis on a yeast two-hybrid platform.Pancreatic beta-cell protein granuphilin binds Rab3 and Munc-18 and controls exocytosis.Melanophilin directly links Rab27a and myosin Va through its distinct coiled-coil regions.Slp4-a/granuphilin-a regulates dense-core vesicle exocytosis in PC12 cells.Synaptotagmin-like protein (Slp) homology domain 1 of Slac2-a/melanophilin is a critical determinant of GTP-dependent specific binding to Rab27A.Melanophilin, the product of the leaden locus, is required for targeting of myosin-Va to melanosomes.Primary hemophagocytic syndromes point to a direct link between lymphocyte cytotoxicity and homeostasis.Involvement of the Rab27 binding protein Slac2c/MyRIP in insulin exocytosis.Rab27 effector Slp2-a transports the apical signaling molecule podocalyxin to the apical surface of MDCK II cells and regulates claudin-2 expression.Synaptotagmin-like proteins control the formation of a single apical membrane domain in epithelial cellsRab27 effectors, pleiotropic regulators in secretory pathways.The C2A domain of synaptotagmin-like protein 3 (Slp3) is an atypical calcium-dependent phospholipid-binding machine: comparison with the C2A domain of synaptotagmin I.Vesicle-associated membrane protein-2/synaptobrevin binding to synaptotagmin I promotes O-glycosylation of synaptotagmin I.Formation of crystalloid endoplasmic reticulum induced by expression of synaptotagmin lacking the conserved WHXL motif in the C terminus. Structural importance of the WHXL motif in the C2B domain.The actin-binding domain of Slac2-a/melanophilin is required for melanosome distribution in melanocytesAtg16L2, a novel isoform of mammalian Atg16L that is not essential for canonical autophagy despite forming an Atg12–5-16L2 complexThe Slp4-a linker domain controls exocytosis through interaction with Munc18-1.syntaxin-1a complex.Functional analysis of Slac2-c/MyRIP as a linker protein between melanosomes and myosin VIIa.Alternative splicing in the first alpha-helical region of the Rab-binding domain of Rim regulates Rab3A binding activity: is Rim a Rab3 effector protein during evolution?Slp4-a/granuphilin-a interacts with syntaxin-2/3 in a Munc18-2-dependent manner.Effect of ovarian cancer ascites on SKOV-3 cells proteome: new proteins associated with aggressive phenotype in epithelial ovarian cancer.
P2860
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P2860
Novel splicing isoforms of synaptotagmin-like proteins 2 and 3: identification of the Slp homology domain
description
2001 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի մայիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2001
@ast
im Mai 2001 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2001/05/04)
@sk
vědecký článek publikovaný v roce 2001
@cs
wetenschappelijk artikel (gepubliceerd op 2001/05/04)
@nl
наукова стаття, опублікована в травні 2001
@uk
مقالة علمية (نشرت في 4-5-2001)
@ar
name
Novel splicing isoforms of syn ...... ion of the Slp homology domain
@ast
Novel splicing isoforms of syn ...... ion of the Slp homology domain
@en
Novel splicing isoforms of syn ...... ion of the Slp homology domain
@nl
type
label
Novel splicing isoforms of syn ...... ion of the Slp homology domain
@ast
Novel splicing isoforms of syn ...... ion of the Slp homology domain
@en
Novel splicing isoforms of syn ...... ion of the Slp homology domain
@nl
prefLabel
Novel splicing isoforms of syn ...... ion of the Slp homology domain
@ast
Novel splicing isoforms of syn ...... ion of the Slp homology domain
@en
Novel splicing isoforms of syn ...... ion of the Slp homology domain
@nl
P356
P1476
Novel splicing isoforms of syn ...... ion of the Slp homology domain
@en
P2093
Mikoshiba K
P304
P356
10.1006/BBRC.2001.4803
P407
P577
2001-05-01T00:00:00Z