Phosphorylation of axin, a Wnt signal negative regulator, by glycogen synthase kinase-3beta regulates its stability
about
Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcriptionGSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with AxinInhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding proteinSynergistic activation of the Wnt signaling pathway by Dvl and casein kinase IepsilonIdentification of AXUD1, a novel human gene induced by AXIN1 and its reduced expression in human carcinomas of the lung, liver, colon and kidneyDisulfide bond assignments of secreted Frizzled-related protein-1 provide insights about Frizzled homology and netrin modulesThe role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway.Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complexStructural and functional characterization of the Wnt inhibitor APC membrane recruitment 1 (Amer1)Regulation of the Wnt signaling pathway by disabled-2 (Dab2)Identification and characterization of a novel Dvl-binding protein that suppresses Wnt signalling pathwayAxin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia.Methylation by protein arginine methyltransferase 1 increases stability of Axin, a negative regulator of Wnt signalingDesumoylation activity of Axam, a novel Axin-binding protein, is involved in downregulation of beta-catenin.A mutational analysis of dishevelled in Drosophila defines novel domains in the dishevelled protein as well as novel suppressing alleles of axinAxin facilitates Smad3 activation in the transforming growth factor beta signaling pathwayWnt/beta-catenin signaling and small molecule inhibitorsGSK-3: tricks of the trade for a multi-tasking kinaseWnt/beta-catenin signaling: components, mechanisms, and diseasesWnt signal transduction pathwaysSUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stabilityWnt signaling: the good and the badThe links between axin and carcinogenesisIntracellular shuttling of a Drosophila APC tumour suppressor homologThe roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathwayWnt signalling in lung development and diseasesToggling a conformational switch in Wnt/β-catenin signaling: regulation of Axin phosphorylation. The phosphorylation state of Axin controls its scaffold function in two Wnt pathway protein complexesGSK-3 as potential target for therapeutic intervention in cancerNormal morphogenesis of epithelial tissues and progression of epithelial tumors.A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of axin and beta-cateninAxin directly interacts with plakoglobin and regulates its stabilityDimerization choices control the ability of axin and dishevelled to activate c-Jun N-terminal kinase/stress-activated protein kinaseCasein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-cateninAxin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathwayCurcumin-induced suppression of adipogenic differentiation is accompanied by activation of Wnt/beta-catenin signalingThe β-catenin destruction complexProtein phosphatase 2A and its B56 regulatory subunit inhibit Wnt signaling in XenopusSulindac sulfide reverses aberrant self-renewal of progenitor cells induced by the AML-associated fusion proteins PML/RARα and PLZF/RARαIn vitro modeling of paraxial mesodermal progenitors derived from induced pluripotent stem cellsBoth the RGS domain and the six C-terminal amino acids of mouse Axin are required for normal embryogenesis
P2860
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P2860
Phosphorylation of axin, a Wnt signal negative regulator, by glycogen synthase kinase-3beta regulates its stability
description
1999 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1999
@ast
im April 1999 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1999/04/16)
@sk
vědecký článek publikovaný v roce 1999
@cs
wetenschappelijk artikel (gepubliceerd op 1999/04/16)
@nl
наукова стаття, опублікована у квітні 1999
@uk
name
Phosphorylation of axin, a Wnt ...... -3beta regulates its stability
@ast
Phosphorylation of axin, a Wnt ...... -3beta regulates its stability
@en
Phosphorylation of axin, a Wnt ...... -3beta regulates its stability
@nl
type
label
Phosphorylation of axin, a Wnt ...... -3beta regulates its stability
@ast
Phosphorylation of axin, a Wnt ...... -3beta regulates its stability
@en
Phosphorylation of axin, a Wnt ...... -3beta regulates its stability
@nl
prefLabel
Phosphorylation of axin, a Wnt ...... -3beta regulates its stability
@ast
Phosphorylation of axin, a Wnt ...... -3beta regulates its stability
@en
Phosphorylation of axin, a Wnt ...... -3beta regulates its stability
@nl
P2093
P2860
P3181
P356
P1476
Phosphorylation of axin, a Wnt ...... -3beta regulates its stability
@en
P2093
P2860
P304
10681–10684
P3181
P356
10.1074/JBC.274.16.10681
P407
P577
1999-04-16T00:00:00Z