p53 suppresses the activation of the Bcl-2 promoter by the Brn-3a POU family transcription factor
about
The transcription factor p53: not a repressor, solely an activatorBrn-3a/POU4F1 interacts with and differentially affects p73-mediated transcriptionHuman survivin is negatively regulated by wild-type p53 and participates in p53-dependent apoptotic pathwayThe miR-34 family in cancer and apoptosisInteraction of Brn3a and HIPK2 mediates transcriptional repression of sensory neuron survivalCardiac expression of Brn-3a and Brn-3b POU transcription factors and regulation of Hsp27 gene expressionGeneration of reactive oxygen species by polyenylpyrroles derivatives causes DNA damage leading to G2/M arrest and apoptosis in human oral squamous cell carcinoma cellsBrn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expressionInhibition of UV-C light-induced apoptosis in liver cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin.Molecular regulation of auditory hair cell death and approaches to protect sensory receptor cells and/or stimulate repair following acoustic trauma.More targets, more pathways and more clues for mutant p53.HIPK2: a multitalented partner for transcription factors in DNA damage response and development.A simple technique for the prediction of interacting proteins reveals a direct Brn-3a-androgen receptor interaction.Spatially and Temporally Regulated NRF2 Gene Therapy Using Mcp-1 Promoter in Retinal Ganglion Cell Injury.Nuclear factor kappaB- and specificity protein 1-dependent p53-mediated bi-directional regulation of the human manganese superoxide dismutase gene.Pro-growth role of the JMJD2C histone demethylase in HCT-116 colon cancer cells and identification of curcuminoids as JMJD2 inhibitors.Dependence of p53-deficient cells on the DHX9 DExH-box helicase.p53 Isoforms: An Intracellular Microprocessor?Intracellular insulin-like growth factor-1 induces Bcl-2 expression in airway epithelial cellsNegative cross-talk between p53 and the glucocorticoid receptor and its role in neuroblastoma cells.Pou4f1 and pou4f2 are dispensable for the long-term survival of adult retinal ganglion cells in mice.Physical and functional antagonism between tumor suppressor protein p53 and fortilin, an anti-apoptotic proteinRegulation of mast cell survival and function by tuberous sclerosis complex 1.Identification of a novel Bcl-2 promoter region that counteracts in a p53-dependent manner the inhibitory P2 region.The neural crest transcription factor Brn3a is expressed in melanoma and required for cell cycle progression and survival.Suppression of MicroRNA 200 Family Expression by Oncogenic KRAS Activation Promotes Cell Survival and Epithelial-Mesenchymal Transition in KRAS-Driven Cancer.Local depletion of DNA methylation identifies a repressive p53 regulatory region in the NEK2 promoter.Codon 104 variation of p53 gene provides adaptive apoptotic responses to extreme environments in mammals of the Tibet plateau.Dioxin toxicity, aryl hydrocarbon receptor signaling, and apoptosis-persistent pollutants affect programmed cell death.Analyses of p53 target genes in the human genome by bioinformatic and microarray approaches.Transcriptional repression by p53 through direct binding to a novel DNA element.The JMJD2A demethylase regulates apoptosis and proliferation in colon cancer cells.Global transcriptional program of p53 target genes during the process of apoptosis and cell cycle progression.p53 responsive elements in human retrotransposons.Long non-coding RNA MEG3 induces renal cell carcinoma cells apoptosis by activating the mitochondrial pathway.Census and evaluation of p53 target genes.Pramanicin analog induces apoptosis in human colon cancer cells: critical roles for Bcl-2, Bim, and p38 MAPK signaling.A minimal Bcl-x promoter is activated by Brn-3a and repressed by p53Distinct promoter elements mediate the co-operative effect of Brn-3a and p53 on the p21 promoter and their antagonism on the Bax promoter.Protein microarray analysis of apoptosis-related protein expression following heat shock in human tongue squamous cell carcinomas containing different p53 phenotypes.
P2860
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P2860
p53 suppresses the activation of the Bcl-2 promoter by the Brn-3a POU family transcription factor
description
1999 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մայիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1999
@ast
im Mai 1999 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1999/05/21)
@sk
vědecký článek publikovaný v roce 1999
@cs
wetenschappelijk artikel (gepubliceerd op 1999/05/21)
@nl
наукова стаття, опублікована в травні 1999
@uk
name
p53 suppresses the activation ...... OU family transcription factor
@ast
p53 suppresses the activation ...... OU family transcription factor
@en
p53 suppresses the activation ...... OU family transcription factor
@nl
type
label
p53 suppresses the activation ...... OU family transcription factor
@ast
p53 suppresses the activation ...... OU family transcription factor
@en
p53 suppresses the activation ...... OU family transcription factor
@nl
prefLabel
p53 suppresses the activation ...... OU family transcription factor
@ast
p53 suppresses the activation ...... OU family transcription factor
@en
p53 suppresses the activation ...... OU family transcription factor
@nl
P2093
P2860
P921
P356
P1476
p53 suppresses the activation ...... OU family transcription factor
@en
P2093
C. A. Midgley
D. S. Latchman
L. M. Boxer
M. D. Smith
P. J. Morris
V. Budhram-Mahadeo
P2860
P304
15237–15244
P356
10.1074/JBC.274.21.15237
P407
P577
1999-05-21T00:00:00Z