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Turning the RING domain protein MdmX into an active ubiquitin-protein ligaseThe tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complexAlterations in gene expression and sensitivity to genotoxic stress following HdmX or Hdm2 knockdown in human tumor cells harboring wild-type p53Regulation by phosphorylation of the relative affinities of the N-terminal transactivation domains of p53 for p300 domains and Mdm2Combined p53-related genetic variants together with HPV infection increase oral cancer riskATM Signaling PathwayGenomic differences between retinoma and retinoblastoma.Identification and characterization of the first small molecule inhibitor of MDMXp53-Responsive micrornas 192 and 215 are capable of inducing cell cycle arrest1,25-dihydroxyvitamin D3 enhances the apoptotic activity of MDM2 antagonist nutlin-3a in acute myeloid leukemia cells expressing wild-type p53.Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damageOne hit, two hits, three hits, more? Genomic changes in the development of retinoblastoma.Spontaneous tumorigenesis in mice overexpressing the p53-negative regulator Mdm4Regulation of p14ARF expression by miR-24: a potential mechanism compromising the p53 response during retinoblastoma development.Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4.Analysis of MDM2 and MDM4 single nucleotide polymorphisms, mRNA splicing and protein expression in retinoblastoma.14-3-3Gamma inhibition of MDMX-mediated p21 turnover independent of p53.Structural and functional comparison of the RING domains of two p53 E3 ligases, Mdm2 and Pirh2.New insights into p53 activationDifferential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage.Regional and temporal differences in gene expression of LH(BETA)T(AG) retinoblastoma tumorsModifying effect of MDM4 variants on risk of HPV16-associated squamous cell carcinoma of oropharynxHypoxia activates tumor suppressor p53 by inducing ATR-Chk1 kinase cascade-mediated phosphorylation and consequent 14-3-3γ inactivation of MDMX protein.The alternative translated MDMX(p60) isoform regulates MDM2 activity.Mdm2 in growth signaling and cancer.Mouse bites dogma: how mouse models are changing our views of how P53 is regulated in vivo.The MDM2-p53 pathway revisitedGuardian of corpulence: a hypothesis on p53 signaling in the fat cell.p53 polymorphisms: cancer implications.5S ribosomal RNA is an essential component of a nascent ribosomal precursor complex that regulates the Hdm2-p53 checkpoint.The structure-based design of Mdm2/Mdmx-p53 inhibitors gets seriousGenetic determinants of neuronal vulnerability to apoptosis.Scission of the p53-MDM2 Loop by Ribosomal Proteins.Mouse models of Mdm2 and Mdm4 and their clinical implications.Mapping genetic alterations causing chemoresistance in cancer: identifying the roads by tracking the drivers.The genomic landscape of retinoblastoma: a review.dapk1, encoding an activator of a p19ARF-p53-mediated apoptotic checkpoint, is a transcription target of p53.Oncogenic functions of hMDMX in in vitro transformation of primary human fibroblasts and embryonic retinoblasts.Lack of Associations of the MDM4 rs4245739 Polymorphism with Risk of Thyroid Cancer among Iranian-Azeri Patients: a Case-Control StudyInterplay between MDM2, MDMX, Pirh2 and COP1: the negative regulators of p53.
P2860
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P2860
description
2004 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2004
@ast
scientific journal article
@en
vedecký článok (publikovaný 2004/07/01)
@sk
vědecký článek publikovaný v roce 2004
@cs
wetenschappelijk artikel (gepubliceerd op 2004/07/01)
@nl
wissenschaftlicher Artikel
@de
наукова стаття, опублікована в липні 2004
@uk
مقالة علمية (نشرت في يوليو 2004)
@ar
name
Mdmx and Mdm2: brothers in arms?
@ast
Mdmx and Mdm2: brothers in arms?
@en
Mdmx and Mdm2: brothers in arms?
@nl
type
label
Mdmx and Mdm2: brothers in arms?
@ast
Mdmx and Mdm2: brothers in arms?
@en
Mdmx and Mdm2: brothers in arms?
@nl
prefLabel
Mdmx and Mdm2: brothers in arms?
@ast
Mdmx and Mdm2: brothers in arms?
@en
Mdmx and Mdm2: brothers in arms?
@nl
P356
P1433
P1476
Mdmx and Mdm2: brothers in arms?
@en
P2093
Aart G Jochemsen
P304
P356
10.4161/CC.3.7.998
P577
2004-07-02T00:00:00Z