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DNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial Inhibition

DNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial Inhibition

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A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability Histone H3 lysine 56 acetylation and the response to DNA replication fork damage Inhibition of Topoisomerase (DNA) I (TOP1): DNA Damage Repair and Anticancer Therapy The Impact of Hedgehog Signaling Pathway on DNA Repair Mechanisms in Human Cancer Mechanisms and regulation of mitotic recombination in Saccharomyces cerevisiae Drugging topoisomerases: lessons and challenges Mitochondrial DNA damage and its consequences for mitochondrial gene expression Programmed activation of cancer cell apoptosis: A tumor-targeted phototherapeutic topoisomerase I inhibitor Assessment of the topoisomerase I gene copy number as a predictive biomarker of objective response to irinotecan in metastatic colorectal cancer.Gli1 protein regulates the S-phase checkpoint in tumor cells via Bid protein, and its inhibition sensitizes to DNA topoisomerase 1 inhibitors Structural and dynamical effects induced by the anticancer drug topotecan on the human topoisomerase I - DNA complex Exploring DNA topoisomerase I ligand space in search of novel anticancer agents Solvent dependency of the UV-Vis spectrum of indenoisoquinolines: role of keto-oxygens as polarity interaction probes Replacement of the human topoisomerase linker domain with the plasmodial counterpart renders the enzyme camptothecin resistant Toward discovering new anti-cancer agents targeting topoisomerase IIα: a facile screening strategy adaptable to high throughput platform CFS-1686 causes cell cycle arrest at intra-S phase by interference of interaction of topoisomerase 1 with DNA Genome-wide mRNA and microRNA profiling of the NCI 60 cell-line screen and comparison of FdUMP[10] with fluorouracil, floxuridine, and topoisomerase 1 poisons Genetically defined subsets of human pancreatic cancer show unique in vitro chemosensitivity.Single-Molecule Supercoil Relaxation Assay as a Screening Tool to Determine the Mechanism and Efficacy of Human Topoisomerase IB Inhibitors.RNA Polymerase II Regulates Topoisomerase 1 Activity to Favor Efficient Transcription.DOSY NMR and MALDI-TOF evidence of covalent binding the DNA duplex by trimethylammonium salts of topotecan upon near UV irradiation.Advantages of an optical nanosensor system for the mechanistic analysis of a novel topoisomerase I targeting drug: a case study.Global fitness profiling of fission yeast deletion strains by barcode sequencing Design, synthesis, and biological evaluation of O-2-modified indenoisoquinolines as dual topoisomerase I-tyrosyl-DNA phosphodiesterase I inhibitors.The DNA relaxation activity and covalent complex accumulation of Mycobacterium tuberculosis topoisomerase I can be assayed in Escherichia coli: application for identification of potential FRET-dye labeling sites.A sandwiched microarray platform for benchtop cell-based high throughput screening.Structure-based design, synthesis, and biological studies of new anticancer norindenoisoquinoline topoisomerase I inhibitors Immobilizing topoisomerase I on a surface plasmon resonance biosensor chip to screen for inhibitors Identification of novel PARP inhibitors using a cell-based TDP1 inhibitory assay in a quantitative high-throughput screening platform.Biochemical assays for the discovery of TDP1 inhibitors Pyrosequencing of the Camptotheca acuminata transcriptome reveals putative genes involved in camptothecin biosynthesis and transport H2AX Phosphorylation: Its Role in DNA Damage Response and Cancer Therapy.Repair-specific functions of replication protein A.A kinetic clutch governs religation by type IB topoisomerases and determines camptothecin sensitivity.Rottlerin potentiates camptothecin-induced cytotoxicity in human hormone refractory prostate cancers through increased formation and stabilization of topoisomerase I-DNA cleavage complexes in a PKCδ-independent pathway.NPRL-Z-1, as a new topoisomerase II poison, induces cell apoptosis and ROS generation in human renal carcinoma cells.Development and validation of an immunoassay for quantification of topoisomerase I in solid tumor tissues The geometry of DNA supercoils modulates the DNA cleavage activity of human topoisomerase I Characterization of DNA topoisomerase-1 in Spodoptera exigua for toxicity evaluation of camptothecin and hydoxy-camptothecin.Protein kinase CK2 is a central regulator of topoisomerase I hyperphosphorylation and camptothecin sensitivity in cancer cell lines

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DNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial Inhibition

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2009年の論文

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DNA T OPOISOMERASES : Structure, Function, and Mechanism

Recent advances in understanding structure–function relationships in the type II topoisomerase mechanism

Cellular roles of dna topoisomerases: a molecular perspective

Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1

Conversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1

Spinocerebellar ataxia with axonal neuropathy: consequence of a Tdp1 recessive neomorphic mutation?

Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC 305831) as an inhibitor of Tdp1

Purification and characterization of human DNA topoisomerase IIIalpha

The tyrosyl-DNA phosphodiesterase Tdp1 is a member of the phospholipase D superfamily

Deficiency in 3'-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1)

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