Determination of substrate motifs for human Chk1 and hCds1/Chk2 by the oriented peptide library approach.
about
Phosphorylation of HuR by Chk2 regulates SIRT1 expressionHuman Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpointPhosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damageChk1 phosphorylation of Metnase enhances DNA repair but inhibits replication fork restartDNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilizationRegulation of MDMX nuclear import and degradation by Chk2 and 14-3-3.14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activationChk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repairNEK11 regulates CDC25A degradation and the IR-induced G2/M checkpointChk1 phosphorylates the tumour suppressor Mig-6, regulating the activation of EGF signallingChk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genesFunctional analysis of C-TAK1 substrate binding and identification of PKP2 as a new C-TAK1 substrate.Differential roles for checkpoint kinases in DNA damage-dependent degradation of the Cdc25A protein phosphataseChk1-mediated phosphorylation of FANCE is required for the Fanconi anemia/BRCA pathwayCHK2 kinase promotes pre-mRNA splicing via phosphorylating CDK11(p110)Suppression of Tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphataseBRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damagePhosphorylation of the regulatory beta-subunit of protein kinase CK2 by checkpoint kinase Chk1: identification of the in vitro CK2beta phosphorylation siteRoles of Chk1 in cell biology and cancer therapyReversal of female infertility by Chk2 ablation reveals the oocyte DNA damage checkpoint pathwayFanconi anemia complementation group FANCD2 protein serine 331 phosphorylation is important for fanconi anemia pathway function and BRCA2 interaction.Large-scale phosphoprotein analysis in Medicago truncatula roots provides insight into in vivo kinase activity in legumes.A single pair of acidic residues in the kinase major groove mediates strong substrate preference for P-2 or P-5 arginine in the AGC, CAMK, and STE kinase families.Importance of a C-terminal conserved region of Chk1 for checkpoint function.NPRL2 sensitizes human non-small cell lung cancer (NSCLC) cells to cisplatin treatment by regulating key components in the DNA repair pathway.A DNA damage-activated checkpoint kinase phosphorylates tau and enhances tau-induced neurodegeneration.Phosphorylation of the MBF repressor Yox1p by the DNA replication checkpoint keeps the G1/S cell-cycle transcriptional program active.Autorepression of rfx1 gene expression: functional conservation from yeast to humans in response to DNA replication arrest.Mitotic phosphorylation of Cdc25B Ser321 disrupts 14-3-3 binding to the high affinity Ser323 siteStructural basis and prediction of substrate specificity in protein serine/threonine kinases.Minichromosome maintenance proteins interact with checkpoint and recombination proteins to promote s-phase genome stability.TGF-beta-induced RhoA and p160ROCK activation is involved in the inhibition of Cdc25A with resultant cell-cycle arrestCK1δ kinase activity is modulated by Chk1-mediated phosphorylation.Pairing centers recruit a Polo-like kinase to orchestrate meiotic chromosome dynamics in C. elegans.Checkpoint kinase 1 prevents cell cycle exit linked to terminal cell differentiation.A phospho-proteomic screen identifies substrates of the checkpoint kinase Chk1.c-Jun N-terminal kinase-mediated Rad18 phosphorylation facilitates Polη recruitment to stalled replication forksRegulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.The Chromosome Axis Mediates Feedback Control of CHK-2 to Ensure Crossover Formation in C. elegans.
P2860
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P2860
Determination of substrate motifs for human Chk1 and hCds1/Chk2 by the oriented peptide library approach.
description
2002 nî lūn-bûn
@nan
2002 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
name
Determination of substrate mot ...... nted peptide library approach.
@ast
Determination of substrate mot ...... nted peptide library approach.
@en
type
label
Determination of substrate mot ...... nted peptide library approach.
@ast
Determination of substrate mot ...... nted peptide library approach.
@en
prefLabel
Determination of substrate mot ...... nted peptide library approach.
@ast
Determination of substrate mot ...... nted peptide library approach.
@en
P2093
P2860
P356
P1476
Determination of substrate mot ...... ented peptide library approach
@en
P2093
Bin-Bing Zhou
Chang-Hun Lee
Fumihiko Kanai
Gary A Rathbun
Jay H Chung
Lauren Giarratani
Matthew Bobiak
Ted O'Neill
P2860
P304
16102-16115
P356
10.1074/JBC.M111705200
P407
P577
2002-01-30T00:00:00Z