Identification of the SH3 domain of GAP as an essential sequence for Ras-GAP-mediated signaling.
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Activated Ras interacts with the Ral guanine nucleotide dissociation stimulatorAlpha 2-chimerin, an SH2-containing GTPase-activating protein for the ras-related protein p21rac derived by alternate splicing of the human n-chimerin gene, is selectively expressed in brain regions and testesA Ras-GTPase-activating protein SH3-domain-binding proteinA novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activationTandem SH2 binding sites mediate the RasGAP-RhoGAP interaction: a conformational mechanism for SH3 domain regulationc-Abl kinase regulates the protein binding activity of c-Crkp190 RhoGAP, the major RasGAP-associated protein, binds GTP directlyGAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunitsThe Ca2+-dependent lipid binding domain of P120GAP mediates protein-protein interactions with Ca2+-dependent membrane-binding proteins. Evidence for a direct interaction between annexin VI and P120GAPThe Ras GTPase-activating protein (GAP) is an SH3 domain-binding protein and substrate for the Src-related tyrosine kinase, HckRas GTPase-activating protein binds to Akt and is required for its activationCharacterization of G3BPs: tissue specific expression, chromosomal localisation and rasGAP(120) binding studies.Involvement of phospholipase Cgamma1 in mouse egg activation induced by a truncated form of the C-kit tyrosine kinase present in spermatozoa.Ras-GAP controls Rho-mediated cytoskeletal reorganization through its SH3 domain.Differential interactions of the growth factor receptor-bound protein 2 N-SH3 domain with son of sevenless and dynamin. Potential role in the Ras-dependent signaling pathway.The Ras-GTPase-activating protein SH3 domain is required for Cdc2 activation and mos induction by oncogenic Ras in Xenopus oocytes independently of mitogen-activated protein kinase activation.SH3 domains specifically regulate kinase activity of expressed Src family proteins.Muscarinic receptors transform NIH 3T3 cells through a Ras-dependent signalling pathway inhibited by the Ras-GTPase-activating protein SH3 domain.Solution structure of GAP SH3 domain by 1H NMR and spatial arrangement of essential Ras signaling-involved sequence.Requirement for Raf and MAP kinase function during the meiotic maturation of Xenopus oocytesA Ras-dependent pathway regulates RNA polymerase II phosphorylation in cardiac myocytes: implications for cardiac hypertrophy.Expression of G3BP and RhoC in esophageal squamous carcinoma and their effect on prognosis.Inhibition of Caenorhabditis elegans vulval induction by gap-1 and by let-23 receptor tyrosine kinaseRasGAP Shields Akt from Deactivating Phosphatases in Fibroblast Growth Factor Signaling but Loses This Ability Once Cleaved by Caspase-3.Negative regulation of p120GAP GTPase promoting activity by p210bcr/abl: implication for RAS-dependent Philadelphia chromosome positive cell growth.Neurofibromin can inhibit Ras-dependent growth by a mechanism independent of its GTPase-accelerating function.Functional role of GTPase-activating protein in cell transformation by pp60v-srcDownregulation of G3BPs inhibits the growth, migration and invasion of human lung carcinoma H1299 cells by suppressing the Src/FAK-associated signaling pathway.The regulation of tyrosine kinase signalling pathways by growth factor and G-protein-coupled receptors.Involvement of the MAP kinase cascade in Xenopus mesoderm induction.rho family GTPase activating proteins p190, bcr and rhoGAP show distinct specificities in vitro and in vivop120 GAP requirement in normal and malignant human hematopoiesis.Inhibitors of the Ras signal transduction pathway as potential antitumour agents.The Ras/p120 GTPase-activating protein (GAP) interaction is regulated by the p120 GAP pleckstrin homology domain.p120 GAP modulates Ras activation of Jun kinases and transformation.Identification of a C-terminal cdc25 sequence required for promotion of germinal vesicle breakdown.Characterization of the C. elegans gap-2 gene encoding a novel Ras-GTPase activating protein and its possible role in larval development.Differential contribution of M(r) 120 kDa rasGTPase-activating protein and neurofibromatosis type 1 gene product during the transition from growth phase to arrested state in human fibroblasts accompanied by a unique rasGTPase-activating activity.The RasGAP N-terminal Fragment Generated by Caspase Cleavage Protects Cells in a Ras/PI3K/Akt-dependent Manner That Does Not Rely on NFκB Activation
P2860
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P2860
Identification of the SH3 domain of GAP as an essential sequence for Ras-GAP-mediated signaling.
description
1993 nî lūn-bûn
@nan
1993 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
Identification of the SH3 doma ...... or Ras-GAP-mediated signaling.
@ast
Identification of the SH3 doma ...... or Ras-GAP-mediated signaling.
@en
type
label
Identification of the SH3 doma ...... or Ras-GAP-mediated signaling.
@ast
Identification of the SH3 doma ...... or Ras-GAP-mediated signaling.
@en
prefLabel
Identification of the SH3 doma ...... or Ras-GAP-mediated signaling.
@ast
Identification of the SH3 doma ...... or Ras-GAP-mediated signaling.
@en
P2093
P356
P1433
P1476
Identification of the SH3 doma ...... or Ras-GAP-mediated signaling.
@en
P2093
Duchesne M
Schweighoffer F
P304
P356
10.1126/SCIENCE.7678707
P407
P577
1993-01-01T00:00:00Z