Rheumatoid factors isolated from patients with autoimmune disorders are derived from germline genes distinct from those encoding the Wa, Po, and Bla cross-reactive idiotypes.
about
Rheumatoid factors from the peripheral blood of two patients with rheumatoid arthritis are genetically heterogeneous and somatically mutatedCrystal Structure of a Human Autoimmune Complex between IgM Rheumatoid Factor RF61 and IgG1 Fc Reveals a Novel Epitope and Evidence for Affinity MaturationHuman IgG Fc-binding phage antibodies constructed from synovial fluid CD38+ B cells of patients with rheumatoid arthritis show the imprints of an antigen-dependent process of somatic hypermutation and clonal selection.Evidence of antigen receptor-influenced oligoclonal B lymphocyte expansion in the synovium of a patient with longstanding rheumatoid arthritis.Defining the genetic origins of three rheumatoid synovium-derived IgG rheumatoid factors.Sequence analyses of three immunoglobulin G anti-virus antibodies reveal their utilization of autoantibody-related immunoglobulin Vh genes, but not V lambda genes.Somatic mutation and CDR3 lengths of immunoglobulin kappa light chains expressed in patients with rheumatoid arthritis and in normal individualsControl of autoantibody affinity by selection against amino acid replacements in the complementarity-determining regionsHuman rheumatoid B-1a (CD5+ B) cells make somatically hypermutated high affinity IgM rheumatoid factorsGenetic analysis of self-associating immunoglobulin G rheumatoid factors from two rheumatoid synovia implicates an antigen-driven responseExtensive and selective mutation of a rearranged VH5 gene in human B cell chronic lymphocytic leukemia.Human rheumatoid factor cross-idiotypes. IV. Studies on WA XId-positive IgM without rheumatoid factor activity provide evidence that the WA XId is not unique to rheumatoid factors and is distinct from the 17.109 and G6 XIds.Impaired early B cell tolerance in patients with rheumatoid arthritis.Cloning and characterisation of TPO autoantibodies using combinatorial phage display libraries.Positional cloning of the Igl genes controlling rheumatoid factor production and allergic bronchitis in ratsThe intestinal B-cell response in celiac disease.A deletion polymorphism in the human alpha-2-macroglobulin (A2M) geneMolecular and cellular mechanisms of joint destruction in rheumatoid arthritis: two cellular mechanisms explain joint destruction?Molecular characterization of monoclonal IgM derived from human B cell lines expressing the 4C9 rheumatoid factor associated idiotype.When do microbes stimulate rheumatoid factor?Light chain variable (VL) sequences of rheumatoid factors (RF) in patients with primary Sjögren's syndrome (pSS): moderate contribution of somatic hypermutation.Analysis of the V kappa III variable regions of polyclonal rheumatoid factors arising during Epstein Barr virus induced infectious mononucleosis.Analysis of the V kappa I family: germline genes from an SLE patient and expressed autoantibodies.A minor group of rheumatoid factors isolated from a patient with rheumatoid arthritis is derived from somatically mutated Vk1 genes further evidence that rheumatoid factors during autoimmune diseases undergo an antigen driven maturation.CD5+ B lymphocytes in systemic lupus erythematosus patients: relation to disease activity.Structure-function analyses of a stereotypic rheumatoid factor unravel the structural basis for germline-encoded antibody autoreactivity.
P2860
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P2860
Rheumatoid factors isolated from patients with autoimmune disorders are derived from germline genes distinct from those encoding the Wa, Po, and Bla cross-reactive idiotypes.
description
1991 nî lūn-bûn
@nan
1991 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1991 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
name
Rheumatoid factors isolated fr ...... Bla cross-reactive idiotypes.
@ast
Rheumatoid factors isolated fr ...... Bla cross-reactive idiotypes.
@en
type
label
Rheumatoid factors isolated fr ...... Bla cross-reactive idiotypes.
@ast
Rheumatoid factors isolated fr ...... Bla cross-reactive idiotypes.
@en
prefLabel
Rheumatoid factors isolated fr ...... Bla cross-reactive idiotypes.
@ast
Rheumatoid factors isolated fr ...... Bla cross-reactive idiotypes.
@en
P2093
P2860
P356
P1476
Rheumatoid factors isolated fr ...... Bla cross-reactive idiotypes.
@en
P2093
P2860
P304
P356
10.1172/JCI115174
P407
P577
1991-05-01T00:00:00Z