Human rheumatoid B-1a (CD5+ B) cells make somatically hypermutated high affinity IgM rheumatoid factors
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Clonally-related immunoglobulin VH domains and nonrandom use of DH gene segments in rheumatoid arthritis synoviumCrystal Structure of a Human Autoimmune Complex between IgM Rheumatoid Factor RF61 and IgG1 Fc Reveals a Novel Epitope and Evidence for Affinity MaturationHuman IgG Fc-binding phage antibodies constructed from synovial fluid CD38+ B cells of patients with rheumatoid arthritis show the imprints of an antigen-dependent process of somatic hypermutation and clonal selection.B cells: the old new players in reproductive immunology.A hallmark of active class switch recombination: transcripts directed by I promoters on looped-out circular DNAs.Defining the genetic origins of three rheumatoid synovium-derived IgG rheumatoid factors.Autocrine stimulation of IL-10 is critical to the enrichment of IL-10-producing CD40(hi)CD5(+) regulatory B cells in vitro and in vivo.Control of autoantibody affinity by selection against amino acid replacements in the complementarity-determining regionsThe antigen-binding domain of a human IgG-anti-F(ab')2 autoantibody.Balancing diversity and tolerance: lessons from patients with systemic lupus erythematosus.Structure-function analysis of a lupus anti-DNA autoantibody: central role of the heavy chain complementarity-determining region 3 Arg in binding of double- and single-stranded DNA.Ongoing in vivo immunoglobulin class switch DNA recombination in chronic lymphocytic leukemia B cells.Structure of the VH and VL segments of monoreactive and polyreactive IgA autoantibodies to DNA in patients with systemic lupus erythematosusStructure of the VH and VL segments of polyreactive and monoreactive human natural antibodies to HIV-1 and Escherichia coli beta-galactosidasePresence of Rheumatoid Factor during Chronic HCV Infection Is Associated with Expansion of Mature Activated Memory B-Cells that Are Hypo-Responsive to B-Cell Receptor Stimulation and Persist during the Early Stage of IFN Free Therapy.Somatic diversification and selection of immunoglobulin heavy and light chain variable region genes in IgG+ CD5+ chronic lymphocytic leukemia B cells.Chronic lymphocytic leukemia B cells can undergo somatic hypermutation and intraclonal immunoglobulin V(H)DJ(H) gene diversification.Nature and functions of autoantibodies.Molecular single-cell analysis reveals that CD5-positive peripheral blood B cells in healthy humans are characterized by rearranged Vkappa genes lacking somatic mutation.The CDR1 sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacement.Rheumatoid factors in primary Sjögren's syndrome (pSS) use diverse VH region genes, the majority of which show no evidence of somatic hypermutation.VHDJH gene sequences and antigen reactivity of monoclonal antibodies produced by human B-1 cells: evidence for somatic selection.Two acquired immunodeficiency syndrome-associated Burkitt's lymphomas produce specific anti-i IgM cold agglutinins using somatically mutated VH4-21 segments.VH and V kappa segment structure of anti-insulin IgG autoantibodies in patients with insulin-dependent diabetes mellitus. Evidence for somatic selection.Structural analysis of the VH-D-JH segments of human polyreactive IgG mAb. Evidence for somatic selection.Analysis of the structural correlates for antibody polyreactivity by multiple reassortments of chimeric human immunoglobulin heavy and light chain V segments.Lack of intraclonal diversification in Ig heavy and light chain V region genes expressed by CD5+IgM+ chronic lymphocytic leukemia B cells: a multiple time point analysisA human anti-insulin IgG autoantibody apparently arises through clonal selection from an insulin-specific "germ-line" natural antibody template. Analysis by V gene segment reassortment and site-directed mutagenesis.Rheumatoid factor is correlated with disease activity and inflammatory markers in antineutrophil cytoplasmic antibody-associated vasculitis.Structure-function analyses of a stereotypic rheumatoid factor unravel the structural basis for germline-encoded antibody autoreactivity.Chronic Lymphocytic Leukemia B-Cell Normal Cellular Counterpart: Clues From a Functional Perspective.CDR3 sequences of MALT lymphoma show homology with those of autoreactive B-cell lines.Plasma Cell Differentiation Pathways in Systemic Lupus Erythematosus.
P2860
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P2860
Human rheumatoid B-1a (CD5+ B) cells make somatically hypermutated high affinity IgM rheumatoid factors
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Human rheumatoid B-1a (CD5+ B) ...... ffinity IgM rheumatoid factors
@ast
Human rheumatoid B-1a (CD5+ B) ...... ffinity IgM rheumatoid factors
@en
type
label
Human rheumatoid B-1a (CD5+ B) ...... ffinity IgM rheumatoid factors
@ast
Human rheumatoid B-1a (CD5+ B) ...... ffinity IgM rheumatoid factors
@en
prefLabel
Human rheumatoid B-1a (CD5+ B) ...... ffinity IgM rheumatoid factors
@ast
Human rheumatoid B-1a (CD5+ B) ...... ffinity IgM rheumatoid factors
@en
P2093
P2860
P1476
Human rheumatoid B-1a (CD5+ B) ...... ffinity IgM rheumatoid factors
@en
P2093
P2860
P304
P407
P577
1993-07-01T00:00:00Z