Polyductin undergoes notch-like processing and regulated release from primary cilia - Wikidata - awgldk - TriplyDB

Polyductin undergoes notch-like processing and regulated release from primary cilia

Polyductin undergoes notch-like processing and regulated release from primary cilia

http://www.wikidata.org/entity/Q30479973

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Uromodulin is expressed in renal primary cilia and UMOD mutations result in decreased ciliary uromodulin expression A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation Fibrocystin/polyductin modulates renal tubular formation by regulating polycystin-2 expression and function Function and dynamics of PKD2 in Chlamydomonas reinhardtii flagella.Rer1p maintains ciliary length and signaling by regulating γ-secretase activity and Foxj1a levels.A Presenilin-2-ARF4 trafficking axis modulates Notch signaling during epidermal differentiation Polycystic kidney disease.Tissue-specific regulation of the mouse Pkhd1 (ARPKD) gene promoter Autosomal recessive polycystic kidney disease epithelial cell model reveals multiple basolateral epidermal growth factor receptor sorting pathways.PKHD1 post-transcriptionally modulated by miR-365-1 inhibits cell-cell adhesion.Transcriptional complexity in autosomal recessive polycystic kidney disease.Processing of the synaptic cell adhesion molecule neurexin-3beta by Alzheimer disease alpha- and gamma-secretases.Cilium, centrosome and cell cycle regulation in polycystic kidney disease.Acute kidney injury and aberrant planar cell polarity induce cyst formation in mice lacking renal cilia.The cytoplasmic tail of FPC antagonizes the full-length protein in the regulation of mTOR pathway Epitope-tagged Pkhd1 tracks the processing, secretion, and localization of fibrocystin.Congenital hepatic fibrosis in autosomal recessive polycystic kidney disease.Protein composition and movements of membrane swellings associated with primary cilia.Genetic interaction studies link autosomal dominant and recessive polycystic kidney disease in a common pathway.SheddomeDB: the ectodomain shedding database for membrane-bound shed markers.Biliary and pancreatic dysgenesis in mice harboring a mutation in Pkhd1.Vasopressin antagonists in polycystic kidney disease.Polycystic kidney diseases: from molecular discoveries to targeted therapeutic strategies Substrate specificity of gamma-secretase and other intramembrane proteases.Characterization of PKD protein-positive exosome-like vesicles.Ciliary dysfunction in polycystic kidney disease: an emerging model with polarizing potential The many substrates of presenilin/γ-secretase.Regulated intramembrane proteolysis: signaling pathways and biological functions.Polycystic liver diseases: congenital disorders of cholangiocyte signaling The physiology of the β-amyloid precursor protein intracellular domain AICD.Caroli's Disease: Current Knowledge of Its Biliary Pathogenesis Obtained from an Orthologous Rat Model.NEDD4-family E3 ligase dysfunction due to PKHD1/Pkhd1 defects suggests a mechanistic model for ARPKD pathobiology.Tagged fibrocystin sheds its secrets.The Roles of Primary cilia in Polycystic Kidney Disease.Polycystin-2 expression is regulated by a PC2-binding domain in the intracellular portion of fibrocystin.Activation of the AKT/mTOR pathway in autosomal recessive polycystic kidney disease (ARPKD).Expansion of divergent SEA domains in cell surface proteins and nucleoporin 54.Recent advances in the molecular diagnosis of polycystic kidney disease.Expanding the role of vasopressin antagonism in polycystic kidney diseases: From adults to children?A novel model of autosomal recessive polycystic kidney questions the role of the fibrocystin C-terminus in disease mechanism.

P2860

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P2860

Polyductin undergoes notch-like processing and regulated release from primary cilia

http://www.wikidata.org/entity/Q30479973

description

2007 nî lūn-bûn

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2007 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2007 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2007年の論文

@ja

2007年論文

@yue

2007年論文

@zh-hant

2007年論文

@zh-hk

2007年論文

@zh-mo

2007年論文

@zh-tw

2007年论文

@wuu

name

Polyductin undergoes notch-like processing and regulated release from primary cilia

@ast

Polyductin undergoes notch-like processing and regulated release from primary cilia

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type

label

Polyductin undergoes notch-like processing and regulated release from primary cilia

@ast

Polyductin undergoes notch-like processing and regulated release from primary cilia

@en

prefLabel

Polyductin undergoes notch-like processing and regulated release from primary cilia

@ast

Polyductin undergoes notch-like processing and regulated release from primary cilia

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P1433

Human Molecular Genetics

P1476

Polyductin undergoes notch-like processing and regulated release from primary cilia

@en

P2093

Enyu Imai

http://www.w3.org/2001/XMLSchema#string

Jie Deng

http://www.w3.org/2001/XMLSchema#string

Jun-ya Kaimori

http://www.w3.org/2001/XMLSchema#string

Lisa M Guay-Woodford

http://www.w3.org/2001/XMLSchema#string

Luis F Menezes

http://www.w3.org/2001/XMLSchema#string

Miguel A Garcia-Gonzalez

http://www.w3.org/2001/XMLSchema#string

Yasuyuki Nagasawa

http://www.w3.org/2001/XMLSchema#string

P2860

The gene mutated in autosomal recessive polycystic kidney disease encodes a large, receptor-like protein

Polyductin, the PKHD1 gene product, comprises isoforms expressed in plasma membrane, primary cilium, and cytoplasm

The autosomal recessive polycystic kidney disease protein is localized to primary cilia, with concentration in the basal body area

Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations.

Furin: a mammalian subtilisin/Kex2p-like endoprotease involved in processing of a wide variety of precursor proteins

The crystal structure of the proprotein processing proteinase furin explains its stringent specificity

Polycystin-2 traffics to cilia independently of polycystin-1 by using an N-terminal RVxP motif.

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

Prediction of proprotein convertase cleavage sites

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

P304

942-956

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scholarly article

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10.1093/HMG/DDM039

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8

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P478

16

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P50

Gregory Germino

P577

2007-04-01T00:00:00Z

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P5875

6360499

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17470460

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1955383

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