Mutation that dramatically alters rat titin isoform expression and cardiomyocyte passive tension - Wikidata - awgldk - TriplyDB

Mutation that dramatically alters rat titin isoform expression and cardiomyocyte passive tension

Mutation that dramatically alters rat titin isoform expression and cardiomyocyte passive tension

http://www.wikidata.org/entity/Q30482992

about

RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing Cyclic stretch of embryonic cardiomyocytes increases proliferation, growth, and expression while repressing Tgf-β signaling Pathophysiological defects and transcriptional profiling in the RBM20-/- rat model Titin-mediated control of cardiac myofibrillar function.Titin diversity--alternative splicing gone wild Rbm20-deficient cardiogenesis reveals early disruption of RNA processing and sarcomere remodeling establishing a developmental etiology for dilated cardiomyopathy.Myofilament length dependent activation The giant protein titin: a regulatory node that integrates myocyte signaling pathways.Magnitude of length-dependent changes in contractile properties varies with titin isoform in rat ventricles.Rbm20 regulates titin alternative splicing as a splicing repressor.Shortening of the elastic tandem immunoglobulin segment of titin leads to diastolic dysfunction.Conformation-regulated mechanosensory control via titin domains in cardiac muscle.Functional roles of alternative splicing factors in human disease.RBM20, a potential target for treatment of cardiomyopathy via titin isoform switching.Impact of titin strain on the cardiac slow force response.Pre-mRNA mis-splicing of sarcomeric genes in heart failure.Historical perspective on heart function: the Frank-Starling Law.Nuances of electrophoresis study of titin/connectin.Some rat: a very special rat with a rather special titin Titin isoform size is not correlated with thin filament length in rat skeletal muscle.Challenges in skeletal muscle physiology.Experimentally Increasing the Compliance of Titin Through RNA Binding Motif-20 (RBM20) Inhibition Improves Diastolic Function In a Mouse Model of Heart Failure With Preserved Ejection Fraction.Impact of titin isoform on length dependent activation and cross-bridge cycling kinetics in rat skeletal muscle.Stressing the giant: a new approach to understanding dilated cardiomyopathy.Muscle-Specific Mis-Splicing and Heart Disease Exemplified by RBM20.TTN genotype is associated with fascicle length and marathon running performance.Insulin regulates titin pre-mRNA splicing through the PI3K-Akt-mTOR kinase axis in a RBM20-dependent manner.Chronic low-intensity exercise attenuates cardiomyocyte contractile dysfunction and impaired adrenergic responsiveness in aortic-banded mini-swine.A mutation in the glutamate-rich region of RNA-binding motif protein 20 causes dilated cardiomyopathy through missplicing of titin and impaired Frank-Starling mechanism.RBM20 and RBM24 cooperatively promote the expression of short enh splice variants.Comprehensive analysis of titin protein isoform and alternative splicing in normal and mutant rats.Phosphorylation of the RSRSP stretch is critical for splicing regulation by RNA-Binding Motif Protein 20 (RBM20) through nuclear localization.

P2860

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P2860

Mutation that dramatically alters rat titin isoform expression and cardiomyocyte passive tension

http://www.wikidata.org/entity/Q30482992

description

2008 nî lūn-bûn

@nan

2008 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2008年の論文

@ja

2008年論文

@yue

2008年論文

@zh-hant

2008年論文

@zh-hk

2008年論文

@zh-mo

2008年論文

@zh-tw

2008年论文

@wuu

name

Mutation that dramatically alt ...... cardiomyocyte passive tension

@ast

Mutation that dramatically alt ...... cardiomyocyte passive tension

@en

type

label

Mutation that dramatically alt ...... cardiomyocyte passive tension

@ast

Mutation that dramatically alt ...... cardiomyocyte passive tension

@en

prefLabel

Mutation that dramatically alt ...... cardiomyocyte passive tension

@ast

Mutation that dramatically alt ...... cardiomyocyte passive tension

@en

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J.YJMCC.2008.02.272

P1433

Journal of Molecular and Cellular Cardiology

P1476

Mutation that dramatically alt ...... cardiomyocyte passive tension

@en

P2093

Amanda M Parrish

http://www.w3.org/2001/XMLSchema#string

Chad M Warren

http://www.w3.org/2001/XMLSchema#string

Daniel P Fitzsimons

http://www.w3.org/2001/XMLSchema#string

Holly S Norman

http://www.w3.org/2001/XMLSchema#string

Karla Esbona

http://www.w3.org/2001/XMLSchema#string

Marion L Greaser

http://www.w3.org/2001/XMLSchema#string

Paul R Krzesinski

http://www.w3.org/2001/XMLSchema#string

Richard L Moss

http://www.w3.org/2001/XMLSchema#string

Sandra Dunning

http://www.w3.org/2001/XMLSchema#string

Wei Guo

http://www.w3.org/2001/XMLSchema#string

P2860

The complete gene sequence of titin, expression of an unusual approximately 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system

Titins: giant proteins in charge of muscle ultrastructure and elasticity

Regulation of skeletal muscle stiffness and elasticity by titin isoforms: a test of the segmental extension model of resting tension

Titin: major myofibrillar components of striated muscle

Basic local alignment search tool

A new mathematical model for relative quantification in real-time RT-PCR

Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays

BLAST 2 Sequences, a new tool for comparing protein and nucleotide sequences

Complete nucleotide sequence and structural organization of rat cardiac troponin T gene

SLControl: PC-based data acquisition and analysis for muscle mechanics.

P304

983-991

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scholarly article

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10.1016/J.YJMCC.2008.02.272

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6

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P478

44

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2008-02-23T00:00:00Z

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5464177

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18387630

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2501117

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