Structural model and functional significance of pH-dependent talin-actin binding for focal adhesion remodeling. - Wikidata - awgldk - TriplyDB

Structural model and functional significance of pH-dependent talin-actin binding for focal adhesion remodeling.

Structural model and functional significance of pH-dependent talin-actin binding for focal adhesion remodeling.

http://www.wikidata.org/entity/Q30483435

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pH sensing and regulation in cancer SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production Ion channels and transporters in tumour cell migration and invasion Na+-H+ exchanger-1 (NHE1) regulation in kidney proximal tubule Cofilin is a pH sensor for actin free barbed end formation: role of phosphoinositide binding Multimodality pH imaging in a mouse dorsal skin fold window chamber model Talin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivity.Adhesion dynamics at a glance.Considering protonation as a posttranslational modification regulating protein structure and function.Prolactin Signaling Stimulates Invasion via Na(+)/H(+) Exchanger NHE1 in T47D Human Breast Cancer Cells Talin regulates moesin-NHE-1 recruitment to invadopodia and promotes mammary tumor metastasis.Histidine-mediated pH-sensitive regulation of M-ficolin:GlcNAc binding activity in innate immunity examined by molecular dynamics simulations.The sodium-hydrogen exchanger NHE1 is an Akt substrate necessary for actin filament reorganization by growth factors Extracellular acidic pH inhibits oligodendrocyte precursor viability, migration, and differentiation The mechanostability of isolated focal adhesions is strongly dependent on pH Comparing Conformational Ensembles Using the Kullback-Leibler Divergence Expansion.Electrostatics control actin filament nucleation and elongation kinetics.Interaction of monocarboxylate transporter 4 with beta1-integrin and its role in cell migration Mislocalized scaffolding by the Na-H exchanger NHE1 dominantly inhibits fibronectin production and TGF-beta activation.pHocal adhesion kinase regulation is on a FERM foundation.pH sensing by FAK-His58 regulates focal adhesion remodeling Increased intracellular pH is necessary for adult epithelial and embryonic stem cell differentiation.Structural Basis for pH-mediated Regulation of F-actin Severing by Gelsolin Domain 1.Electrochemical regulation of cell polarity and the cytoskeleton.Roles of ion transport in control of cell motility.Extracellular acidity, a "reappreciated" trait of tumor environment driving malignancy: perspectives in diagnosis and therapy.Pivotal role of pervasive neoplastic and stromal cells reprogramming in circulating tumor cells dissemination and metastatic colonization.A Histidine Cluster in the Cytoplasmic Domain of the Na-H Exchanger NHE1 Confers pH-sensitive Phospholipid Binding and Regulates Transporter Activity.Osmotic shrinkage elicits FAK- and Src phosphorylation and Src-dependent NKCC1 activation in NIH3T3 cells.Cancer cell behaviors mediated by dysregulated pH dynamics at a glance.In silico modeling of pH-optimum of protein-protein binding.The Na+ /H+ -exchanger (NHE1) generates pH nanodomains at focal adhesions.Physical and Chemical Gradients in the Tumor Microenvironment Regulate Tumor Cell Invasion, Migration, and Metastasis.Decorin and chondroitin-6 sulfate inhibit B16V melanoma cell migration and invasion by cellular acidification.Intracellular pH gradients in migrating cells.Regulation of early neurite morphogenesis by the Na+/H+ exchanger NHE1.The effect of carbonic anhydrase IX on focal contacts during cell spreading and migration.A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1.On the pH-optimum of activity and stability of proteins.Cell fate decisions: emerging roles for metabolic signals and cell morphology.

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P2860

Structural model and functional significance of pH-dependent talin-actin binding for focal adhesion remodeling.

http://www.wikidata.org/entity/Q30483435

description

2008 nî lūn-bûn

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2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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Structural model and functiona ...... for focal adhesion remodeling.

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Structural model and functiona ...... for focal adhesion remodeling.

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Structural model and functiona ...... for focal adhesion remodeling.

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Structural model and functiona ...... for focal adhesion remodeling.

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Structural model and functiona ...... for focal adhesion remodeling.

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Proceedings of the National Academy of Sciences of the United States of America

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Structural model and functiona ...... for focal adhesion remodeling.

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P2093

A R Gingras

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B T Goult

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D L Barber

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D R Critchley

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G Barreiro

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J Srivastava

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M J S Kelly

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S Groscurth

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P2860

Cytoskeletal proteins talin and vinculin in integrin-mediated adhesion

Solution structure of human cofilin: actin binding, pH sensitivity, and relationship to actin-depolymerizing factor

The structure of the C-terminal actin-binding domain of talin

VMD: visual molecular dynamics

Structural definition of the F-actin-binding THATCH domain from HIP1R

Direct binding of the Na--H exchanger NHE1 to ERM proteins regulates the cortical cytoskeleton and cell shape independently of H(+) translocation

The Nck-interacting kinase (NIK) phosphorylates the Na+-H+ exchanger NHE1 and regulates NHE1 activation by platelet-derived growth factor

The phosphotyrosine binding-like domain of talin activates integrins

Positive feedback between Cdc42 activity and H+ efflux by the Na-H exchanger NHE1 for polarity of migrating cells

Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talin

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14436-14441

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10.1073/PNAS.0805163105

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38

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105

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Matthew P. Jacobson

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