Absence epilepsy in apathetic, a spontaneous mutant mouse lacking the h channel subunit, HCN2
about
Epileptiform activity and cognitive deficits in SNAP-25(+/-) mice are normalized by antiepileptic drugsDeletion of the hyperpolarization-activated cyclic nucleotide-gated channel auxiliary subunit TRIP8b impairs hippocampal Ih localization and function and promotes antidepressant behavior in mice.BACE1-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localizationDecreased viability and absence-like epilepsy in mice lacking or deficient in the GABAA receptor α1 subunit.Reduction of thalamic and cortical Ih by deletion of TRIP8b produces a mouse model of human absence epilepsy.The Ih Channel Gene Promotes Synaptic Transmission and Coordinated Movement in Drosophila melanogaster.Ih current is necessary to maintain normal dopamine fluctuations and sleep consolidation in Drosophila.HCN channelopathy in external globus pallidus neurons in models of Parkinson's disease.HCN channels in behavior and neurological disease: too hyper or not active enough?Low brain ascorbic acid increases susceptibility to seizures in mouse models of decreased brain ascorbic acid transport and Alzheimer's diseaseThe fast and slow ups and downs of HCN channel regulation.How can we identify ictal and interictal abnormal activity?Decreased hyperpolarization-activated currents in layer 5 pyramidal neurons enhances excitability in focal cortical dysplasia.Thalamocortical neurons display suppressed burst-firing due to an enhanced Ih current in a genetic model of absence epilepsyHCN channelopathies: pathophysiology in genetic epilepsy and therapeutic implicationsAn N-terminal deletion variant of HCN1 in the epileptic WAG/Rij strain modulates HCN current densities.Regulation of epileptiform discharges in rat neocortex by HCN channelsAlternatively spliced isoforms of TRIP8b differentially control h channel trafficking and function.Novel association of early onset hepatocellular carcinoma with transaldolase deficiencyGenomic biomarkers of SUDEP in brain and heart.Towards an integrated view of HCN channel role in epilepsy.HCN channels--modulators of cardiac and neuronal excitability.Dysfunctional HCN ion channels in neurological diseases.Heat induced temperature dysregulation and seizures in Dravet Syndrome/GEFS+ Gabrg2+/Q390X mice.Two approaches reveal a new paradigm of 'switchable or genetics-influenced allele-specific DNA methylation' with potential in human disease.Gain-of-function HCN2 variants in genetic epilepsy.Allostery between two binding sites in the ion channel subunit TRIP8b confers binding specificity to HCN channels.Roles of the subthalamic nucleus and subthalamic HCN channels in absence seizures.Loss of HCN2 leads to delayed gastrointestinal motility and reduced energy intake in mice.A Loss-of-Function Mutation Associated With Familial Benign Myoclonic Epilepsy in Infancy Causes Increased Neuronal Excitability
P2860
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P2860
Absence epilepsy in apathetic, a spontaneous mutant mouse lacking the h channel subunit, HCN2
description
2008 nî lūn-bûn
@nan
2008 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Absence epilepsy in apathetic, ...... ng the h channel subunit, HCN2
@ast
Absence epilepsy in apathetic, ...... ng the h channel subunit, HCN2
@en
type
label
Absence epilepsy in apathetic, ...... ng the h channel subunit, HCN2
@ast
Absence epilepsy in apathetic, ...... ng the h channel subunit, HCN2
@en
prefLabel
Absence epilepsy in apathetic, ...... ng the h channel subunit, HCN2
@ast
Absence epilepsy in apathetic, ...... ng the h channel subunit, HCN2
@en
P2093
P2860
P1476
Absence epilepsy in apathetic, ...... ng the h channel subunit, HCN2
@en
P2093
Ayman A Gheith
Charles A LeDuc
Dane M Chetkovich
Efthia Tzilianos
Minyoung Shin
Rudolph L Leibel
Stuart G Fischer
Thomas C Jaramillo
Wendy K Chung
P2860
P304
P356
10.1016/J.NBD.2008.12.004
P577
2008-12-25T00:00:00Z