The DNA-damage effector checkpoint kinase 1 is essential for chromosome segregation and cytokinesis. - Wikidata - awgldk - TriplyDB

The DNA-damage effector checkpoint kinase 1 is essential for chromosome segregation and cytokinesis.

The DNA-damage effector checkpoint kinase 1 is essential for chromosome segregation and cytokinesis.

http://www.wikidata.org/entity/Q30486781

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Phosphorylation at serine 331 is required for Aurora B activation.MiR-15 family regulates postnatal mitotic arrest of cardiomyocytes DNA damage control: regulation and functions of checkpoint kinase 1 Checkpoint kinase 1 is essential for meiotic cell cycle regulation in mouse oocytes Checkpoint kinase 1 in DNA damage response and cell cycle regulation Roles of Chk1 in cell biology and cancer therapy DNA damage response genes and the development of cancer metastasis Targeting sphingosine kinase 1 in carcinoma cells decreases proliferation and survival by compromising PKC activity and cytokinesis Connecting the microtubule attachment status of each kinetochore to cell cycle arrest through the spindle assembly checkpoint.DNA damage-induced cell death is enhanced by progression through mitosis Cell cycle-dependent localization of CHK2 at centrosomes during mitosis.Chk1 inhibition in p53-deficient cell lines drives rapid chromosome fragmentation followed by caspase-independent cell death ATR and a Chk1-Aurora B pathway coordinate postmitotic genome surveillance with cytokinetic abscission.Chk1 haploinsufficiency results in anemia and defective erythropoiesis.Histone deacetylase inhibitors downregulate checkpoint kinase 1 expression to induce cell death in non-small cell lung cancer cells New insights into checkpoint kinase 1 in the DNA damage response signaling network.Combined inhibition of Chk1 and Wee1: in vitro synergistic effect translates to tumor growth inhibition in vivo.The chromosomal instability pathway in colon cancer Resolution of Toll-like receptor 4-mediated acute lung injury is linked to eicosanoids and suppressor of cytokine signaling 3 Give me a break, but not in mitosis: the mitotic DNA damage response marks DNA double-strand breaks with early signaling events DNA damage response and spindle assembly checkpoint function throughout the cell cycle to ensure genomic integrity.Secretion modification region-derived peptide disrupts HIV-1 Nef's interaction with mortalin and blocks virus and Nef exosome release.Potentiation of the novel topoisomerase I inhibitor indenoisoquinoline LMP-400 by the cell checkpoint and Chk1-Chk2 inhibitor AZD7762.Chk1 suppresses bypass of mitosis and tetraploidization in p53-deficient cancer cells CCT244747 is a novel potent and selective CHK1 inhibitor with oral efficacy alone and in combination with genotoxic anticancer drugs.The role of microRNAs in cardiac development and regenerative capacity.Candidate tumor suppressor BTG3 maintains genomic stability by promoting Lys63-linked ubiquitination and activation of the checkpoint kinase CHK1 A double-edged sword: how oncogenes and tumor suppressor genes can contribute to chromosomal instability The spindle assembly checkpoint: More than just keeping track of the spindle.Chk1 inhibition significantly potentiates activity of nucleoside analogs in TP53-mutated B-lymphoid cells Rad51-dependent aberrant chromosome structures at telomeres and ribosomal DNA activate the spindle assembly checkpoint.Cytokinesis and cancer.Checkpoint control and cancer.The DNA damage effector Chk1 kinase regulates Cdc14B nucleolar shuttling during cell cycle progression.Green synthesis of bacterial mediated anti-proliferative gold nanoparticles: inducing mitotic arrest (G2/M phase) and apoptosis (intrinsic pathway).Characterization and preclinical development of LY2603618: a selective and potent Chk1 inhibitor.A potent Chk1 inhibitor is selectively cytotoxic in melanomas with high levels of replicative stress.MK-8776, a novel Chk1 inhibitor, exhibits an improved radiosensitizing effect compared to UCN-01 by exacerbating radiation-induced aberrant mitosis.Premature chromosome condensation induced by caffeine, 2-aminopurine, staurosporine and sodium metavanadate in S-phase arrested HeLa cells is associated with a decrease in Chk1 phosphorylation, formation of phospho-H2AX and minor cytoskeletal rearra Genetic instability and mammary tumor formation in mice carrying mammary-specific disruption of Chk1 and p53.

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The DNA-damage effector checkpoint kinase 1 is essential for chromosome segregation and cytokinesis.

http://www.wikidata.org/entity/Q30486781

description

2009 nî lūn-bûn

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2009 թուականի Մարտին հրատարակուած գիտական յօդուած

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2009 թվականի մարտին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

The DNA-damage effector checkp ...... e segregation and cytokinesis.

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The DNA-damage effector checkp ...... e segregation and cytokinesis.

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type

label

The DNA-damage effector checkp ...... e segregation and cytokinesis.

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The DNA-damage effector checkp ...... e segregation and cytokinesis.

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The DNA-damage effector checkp ...... e segregation and cytokinesis.

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The DNA-damage effector checkp ...... e segregation and cytokinesis.

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P1476

The DNA-damage effector checkp ...... e segregation and cytokinesis.

@en

P2093

Jeffrey M Rosen

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Maria Gonzalez-Rimbau

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Michael H Lam

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Sirisha Peddibhotla

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P2860

ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

AIM-1: a mammalian midbody-associated protein required for cytokinesis

TopBP1 localises to centrosomes in mitosis and to chromosome cores in meiosis

Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice

Aberrant quantity and localization of Aurora-B/AIM-1 and survivin during megakaryocyte polyploidization and the consequences of Aurora-B/AIM-1-deregulated expression

Abnormal cytokinesis in cells deficient in the breast cancer susceptibility protein BRCA2

Chk1 and Chk2 kinases in checkpoint control and cancer

Cell cycle checkpoint signaling through the ATM and ATR kinases

Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells

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5159-5164

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19289837

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