GABAergic interneuron development and function is modulated by the Tsc1 gene. - Wikidata - awgldk - TriplyDB

GABAergic interneuron development and function is modulated by the Tsc1 gene.

GABAergic interneuron development and function is modulated by the Tsc1 gene.

http://www.wikidata.org/entity/Q30523993

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The involvement of Reelin in neurodevelopmental disorders.Mammalian Target of Rapamycin: Its Role in Early Neural Development and in Adult and Aged Brain Function Excitatory/Inhibitory Balance and Circuit Homeostasis in Autism Spectrum Disorders NINDS epilepsy and autism spectrum disorders workshop report Loss of mTOR-dependent macroautophagy causes autistic-like synaptic pruning deficits Primary Cilia as a Possible Link between Left-Right Asymmetry and Neurodevelopmental Diseases.Deletion of Rictor in neural progenitor cells reveals contributions of mTORC2 signaling to tuberous sclerosis complex.A circuitry and biochemical basis for tuberous sclerosis symptoms: from epilepsy to neurocognitive deficits Early neurodevelopmental screening in tuberous sclerosis complex: a potential window of opportunity.GABA system dysfunction in autism and related disorders: from synapse to symptoms Tuberous Sclerosis: A New Frontier in Targeted Treatment of Autism Multiple roles for mammalian target of rapamycin signaling in both glutamatergic and GABAergic synaptic transmission Impaired autophagy in neurons after disinhibition of mammalian target of rapamycin and its contribution to epileptogenesis.Hypomyelination following deletion of Tsc2 in oligodendrocyte precursors.Lighting a path: genetic studies pinpoint neurodevelopmental mechanisms in autism and related disorders.Early rescue of interneuron disease trajectory in developmental epilepsies.Hypoxia-inducible factor 1a is a Tsc1-regulated survival factor in newborn neurons in tuberous sclerosis complex Patient heal thyself: modeling and treating neurological disorders using patient-derived stem cells.Mammalian target of rapamycin (mTOR) inhibition: potential for antiseizure, antiepileptogenic, and epileptostatic therapy.Modulatory effects of inhibition on persistent activity in a cortical microcircuit model.A common susceptibility factor of both autism and epilepsy: functional deficiency of GABA A receptors.The mTOR signaling pathway in the brain: focus on epilepsy and epileptogenesis.The complex contribution of NOS interneurons in the physiology of cerebrovascular regulation.mTOR signaling in neural stem cells: from basic biology to disease.Pathophysiology of epileptic encephalopathies.Zebrafish as a systems toxicology model for developmental neurotoxicity testing.Genetic animal models of malformations of cortical development and epilepsy.Excitatory/inhibitory imbalance in autism spectrum disorders: Implications for interventions and therapeutics.Neonatal and Infantile Epilepsy: Acquired and Genetic Models.Cortical interneuron dysfunction in epilepsy associated with autism spectrum disorders.Neurobiological bases of autism-epilepsy comorbidity: a focus on excitation/inhibition imbalance.Conditional and domain-specific inactivation of the Tsc2 gene in neural progenitor cells.Complex Neurological Phenotype in Mutant Mice Lacking Tsc2 in Excitatory Neurons of the Developing Forebrain(123).Molecular and Neural Functions of Rai1, the Causal Gene for Smith-Magenis Syndrome.Thyroid hormone-dependent development of early cortical networks: temporal specificity and the contribution of trkB and mTOR pathways.Loss of mTORC2 signaling in oligodendrocyte precursor cells delays myelination.Addressing sufficiency of the CB1 receptor for endocannabinoid-mediated functions through conditional genetic rescue in forebrain GABAergic neurons.Somatic Mutations Activating the mTOR Pathway in Dorsal Telencephalic Progenitors Cause a Continuum of Cortical Dysplasias.Hippocampal GABAergic Inhibitory Interneurons.mTOR Signaling and Neural Stem Cells: The Tuberous Sclerosis Complex Model.

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P2860

GABAergic interneuron development and function is modulated by the Tsc1 gene.

http://www.wikidata.org/entity/Q30523993

description

2011 nî lūn-bûn

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2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

GABAergic interneuron development and function is modulated by the Tsc1 gene.

@ast

GABAergic interneuron development and function is modulated by the Tsc1 gene.

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type

label

GABAergic interneuron development and function is modulated by the Tsc1 gene.

@ast

GABAergic interneuron development and function is modulated by the Tsc1 gene.

@en

prefLabel

GABAergic interneuron development and function is modulated by the Tsc1 gene.

@ast

GABAergic interneuron development and function is modulated by the Tsc1 gene.

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Cerebral Cortex

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GABAergic interneuron development and function is modulated by the Tsc1 gene.

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P2093

Adrienne Bruce

http://www.w3.org/2001/XMLSchema#string

Bryan Cawthon

http://www.w3.org/2001/XMLSchema#string

Cary Fu

http://www.w3.org/2001/XMLSchema#string

Kevin C Ess

http://www.w3.org/2001/XMLSchema#string

Peggy Winzenburger

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William Clinkscales

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P2860

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

Resveratrol inhibits mTOR signaling by promoting the interaction between mTOR and DEPTOR

A complex interplay between Akt, TSC2 and the two mTOR complexes

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

Upstream and downstream of mTOR

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

A mouse model of tuberous sclerosis: neuronal loss of Tsc1 causes dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survival

The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy

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2111-2119

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scholarly article

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10.1093/CERCOR/BHR300

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9

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22

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51737250

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22021912

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3412444

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