Differential roles of the ubiquitin proteasome system and autophagy in the clearance of soluble and aggregated TDP-43 species - Wikidata - awgldk - TriplyDB

Differential roles of the ubiquitin proteasome system and autophagy in the clearance of soluble and aggregated TDP-43 species

Differential roles of the ubiquitin proteasome system and autophagy in the clearance of soluble and aggregated TDP-43 species

http://www.wikidata.org/entity/Q30574024

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TDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets.Autophagosome dynamics in neurodegeneration at a glance Legal but lethal: functional protein aggregation at the verge of toxicity Parkinson Disease-linked Vps35 R524W Mutation Impairs the Endosomal Association of Retromer and Induces α-Synuclein Aggregation Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death Distinct partitioning of ALS associated TDP-43, FUS and SOD1 mutants into cellular inclusions Protein Quality Control and the Amyotrophic Lateral Sclerosis/Frontotemporal Dementia Continuum Formation and spreading of TDP-43 aggregates in cultured neuronal and glial cells demonstrated by time-lapse imaging.Drosophila lines with mutant and wild type human TDP-43 replacing the endogenous gene reveals phosphorylation and ubiquitination in mutant lines in the absence of viability or lifespan defects.p62 plays a protective role in the autophagic degradation of polyglutamine protein oligomers in polyglutamine disease model flies.UBE2E ubiquitin-conjugating enzymes and ubiquitin isopeptidase Y regulate TDP-43 protein ubiquitination.Novel mutations support a role for Profilin 1 in the pathogenesis of ALS.Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways.PABPN1 suppresses TDP-43 toxicity in ALS disease models.Activation of ER Stress and Autophagy Induced by TDP-43 A315T as Pathogenic Mechanism and the Corresponding Histological Changes in Skin as Potential Biomarker for ALS with the Mutation Altered localization and functionality of TAR DNA Binding Protein 43 (TDP-43) in niemann- pick disease type C Loss of RAD-23 Protects Against Models of Motor Neuron Disease by Enhancing Mutant Protein Clearance TDP-43 or FUS-induced misfolded human wild-type SOD1 can propagate intercellularly in a prion-like fashion Defective recognition of LC3B by mutant SQSTM1/p62 implicates impairment of autophagy as a pathogenic mechanism in ALS-FTLD.An insoluble frontotemporal lobar degeneration-associated TDP-43 C-terminal fragment causes neurodegeneration and hippocampus pathology in transgenic mice Functional recovery in new mouse models of ALS/FTLD after clearance of pathological cytoplasmic TDP-43.Autophagy in neuronal cells: general principles and physiological and pathological functions.Prion degradation pathways: Potential for therapeutic intervention.Modelling FUS Mislocalisation in an In Vitro Model of Innervated Human Muscle.Identification of biological pathways regulated by PGRN and GRN peptide treatments using transcriptome analysis.Mahogunin Ring Finger-1 (MGRN1), a Multifaceted Ubiquitin Ligase: Recent Unraveling of Neurobiological Mechanisms.Exosome secretion is a key pathway for clearance of pathological TDP-43.Stress granules at the intersection of autophagy and ALS.The cleavage pattern of TDP-43 determines its rate of clearance and cytotoxicity.TDP-43/FUS in motor neuron disease: Complexity and challenges.Autophagy and Its Impact on Neurodegenerative Diseases: New Roles for TDP-43 and C9orf72.TDP-43 in the spectrum of MND-FTLD pathologies.The heat shock response plays an important role in TDP-43 clearance: evidence for dysfunction in amyotrophic lateral sclerosis Proteostasis disturbance in amyotrophic lateral sclerosis.Clusterin protects neurons against intracellular proteotoxicity.Endocytosis regulates TDP-43 toxicity and turnover.Is amyotrophic lateral sclerosis/frontotemporal dementia an autophagy disease?Ubiquitin-Binding Protein CG5445 Suppresses Aggregation and Cytotoxicity of Amyotrophic Lateral Sclerosis-linked TDP-43 in Drosophila.The Effect of Different Types of Nanoparticles on FUS and TDP-43 Solubility and Subcellular Localization.Inhibition of Drp1/Fis1 interaction slows progression of amyotrophic lateral sclerosis.

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Differential roles of the ubiquitin proteasome system and autophagy in the clearance of soluble and aggregated TDP-43 species

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description

2014 nî lūn-bûn

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2014 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2014 թվականի հունվարին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Differential roles of the ubiq ...... and aggregated TDP-43 species

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Differential roles of the ubiq ...... and aggregated TDP-43 species

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Differential roles of the ubiq ...... and aggregated TDP-43 species

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Differential roles of the ubiq ...... and aggregated TDP-43 species

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Differential roles of the ubiq ...... and aggregated TDP-43 species

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Differential roles of the ubiq ...... and aggregated TDP-43 species

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Journal of Cell Science

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Differential roles of the ubiq ...... and aggregated TDP-43 species

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P2093

Agnes L Nishimura

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David C Rubinsztein

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Han-Jou Chen

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Hazel Urwin

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Jacqueline C Mitchell

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Valentina Sardone

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P2860

The UBL domain of PLIC-1 regulates aggresome formation

p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3

The Microprocessor complex mediates the genesis of microRNAs

Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy

HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia

Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation

Rapamycin rescues TDP-43 mislocalization and the associated low molecular mass neurofilament instability

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10.1242/JCS.140087

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Pt 6

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127

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24424030

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P921

ubiquitin-proteasome system

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3953816

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