A dual role for the kinase-like domain of the tyrosine kinase Tyk2 in interferon-alpha signaling.
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Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRADPolymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosusRegulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1.A natural mutation in the Tyk2 pseudokinase domain underlies altered susceptibility of B10.Q/J mice to infection and autoimmunityTYK2 kinase activity is required for functional type I interferon responses in vivoCombining multiple structure and sequence alignments to improve sequence detection and alignment: application to the SH2 domains of Janus kinases.The SARS Coronavirus 3a protein causes endoplasmic reticulum stress and induces ligand-independent downregulation of the type 1 interferon receptor.Cbl-mediated K63-linked ubiquitination of JAK2 enhances JAK2 phosphorylation and signal transduction.The tyrosine kinase Tyk2 controls IFNAR1 cell surface expression.The JAK/STAT pathway and Drosophila development.The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction.ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activationMolecular insights into regulation of JAK2 in myeloproliferative neoplasmsActivation of the Ras/Raf/MEK pathway facilitates hepatitis C virus replication via attenuation of the interferon-JAK-STAT pathway.Janus kinase 3: the controller and the controlledStructural and Functional Characterization of the JH2 Pseudokinase Domain of JAK Family Tyrosine Kinase 2 (TYK2).Biology and significance of the JAK/STAT signalling pathways.Perspectives for the use of structural information and chemical genetics to develop inhibitors of Janus kinasesTherapeutic potential of tyrosine kinase 2 in autoimmunity.Nucleotide-binding mechanisms in pseudokinases.Autoinhibition of Jak2 tyrosine kinase is dependent on specific regions in its pseudokinase domain.Regulation of Jak2 function by phosphorylation of Tyr317 and Tyr637 during cytokine signaling.The Stat3-activating Tyk2 V678F mutant does not up-regulate signaling through the type I interferon receptor but confers ligand hypersensitivity to a homodimeric receptor.JAK1 and Tyk2 activation by the homologous polycythemia vera JAK2 V617F mutation: cross-talk with IGF1 receptor.Phosphorylation and specific ubiquitin acceptor sites are required for ubiquitination and degradation of the IFNAR1 subunit of type I interferon receptor.Janus kinase (Jak) subcellular localization revisited: the exclusive membrane localization of endogenous Janus kinase 1 by cytokine receptor interaction uncovers the Jak.receptor complex to be equivalent to a receptor tyrosine kinase.Association between TYK2 polymorphisms and susceptibility to autoimmune rheumatic diseases: a meta-analysis.Tyrosine phosphorylation of Jak2 in the JH2 domain inhibits cytokine signaling.Phosphorylation of Jak2 on Ser(523) inhibits Jak2-dependent leptin receptor signaling.A Kaposi's sarcoma-associated herpesvirus protein that forms inhibitory complexes with type I interferon receptor subunits, Jak and STAT proteins, and blocks interferon-mediated signal transduction.The receptor interaction region of Tyk2 contains a motif required for its nuclear localization.TYK2-induced phosphorylation of Y640 suppresses STAT3 transcriptional activity.Associations between PXK and TYK2 polymorphisms and systemic lupus erythematosus: a meta-analysis.A region encompassing the FERM domain of Jak1 is necessary for binding to the cytokine receptor gp130
P2860
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P2860
A dual role for the kinase-like domain of the tyrosine kinase Tyk2 in interferon-alpha signaling.
description
2000 nî lūn-bûn
@nan
2000 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
A dual role for the kinase-lik ...... in interferon-alpha signaling.
@ast
A dual role for the kinase-lik ...... in interferon-alpha signaling.
@en
type
label
A dual role for the kinase-lik ...... in interferon-alpha signaling.
@ast
A dual role for the kinase-lik ...... in interferon-alpha signaling.
@en
prefLabel
A dual role for the kinase-lik ...... in interferon-alpha signaling.
@ast
A dual role for the kinase-lik ...... in interferon-alpha signaling.
@en
P2093
P2860
P356
P1476
A dual role for the kinase-lik ...... in interferon-alpha signaling.
@en
P2093
P2860
P304
P356
10.1073/PNAS.160130297
P407
P577
2000-08-01T00:00:00Z