DNA topoisomerase II as the target for the anticancer drug TOP-53: mechanistic basis for drug action.
about
Mms22p protects Saccharomyces cerevisiae from DNA damage induced by topoisomerase IIStructural basis of type II topoisomerase inhibition by the anticancer drug etoposideTyrosyl-DNA phosphodiesterase (Tdp1) participates in the repair of Top2-mediated DNA damageAn integrated Drosophila model system reveals unique properties for F14512, a novel polyamine-containing anticancer drug that targets topoisomerase IITopoisomerase II - drug interaction domains: identification of substituents on etoposide that interact with the enzyme.Interactions between the etoposide derivative F14512 and human type II topoisomerases: implications for the C4 spermine moiety in promoting enzyme-mediated DNA cleavageContributions of the D-Ring to the activity of etoposide against human topoisomerase IIα: potential interactions with DNA in the ternary enzyme--drug--DNA complex.Yeast recombination pathways triggered by topoisomerase II-mediated DNA breaks.DNA repair functions that control sensitivity to topoisomerase-targeting drugsThe geometry of DNA supercoils modulates topoisomerase-mediated DNA cleavage and enzyme response to anticancer drugs.The efficacy of topoisomerase II-targeted anticancer agents reflects the persistence of drug-induced cleavage complexes in cellsUsing 3'-bridging phosphorothiolates to isolate the forward DNA cleavage reaction of human topoisomerase IIalphaSubstituents on etoposide that interact with human topoisomerase IIalpha in the binary enzyme-drug complex: contributions to etoposide binding and activity.Design, synthesis and cytotoxic activity of novel sulfonylurea derivatives of podophyllotoxin.Toward synthesis of third-generation spin-labeled podophyllotoxin derivatives using isocyanide multicomponent reactionsPhytochemicals as Anticancer and Chemopreventive Topoisomerase II Poisons.Topoisomerase as target for antibacterial and anticancer drug discovery.Synthesis and biological evaluation of 4α/4β-imidazolyl podophyllotoxin analogues as antitumor agents.Inhibition of Topoisomerase IIα and Induction of Apoptosis in Gastric Cancer Cells by 19-Triisopropyl AndrographolideCoupling the core of the anticancer drug etoposide to an oligonucleotide induces topoisomerase II-mediated cleavage at specific DNA sequences.Site-Specific Cleavage by Topoisomerase 2: A Mark of the Core Centromere.
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P2860
DNA topoisomerase II as the target for the anticancer drug TOP-53: mechanistic basis for drug action.
description
2001 nî lūn-bûn
@nan
2001 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
DNA topoisomerase II as the ta ...... anistic basis for drug action.
@ast
DNA topoisomerase II as the ta ...... anistic basis for drug action.
@en
type
label
DNA topoisomerase II as the ta ...... anistic basis for drug action.
@ast
DNA topoisomerase II as the ta ...... anistic basis for drug action.
@en
prefLabel
DNA topoisomerase II as the ta ...... anistic basis for drug action.
@ast
DNA topoisomerase II as the ta ...... anistic basis for drug action.
@en
P2093
P356
P1433
P1476
DNA topoisomerase II as the ta ...... anistic basis for drug action.
@en
P2093
P304
P356
10.1021/BI0021838
P407
P577
2001-01-01T00:00:00Z