Using 3'-bridging phosphorothiolates to isolate the forward DNA cleavage reaction of human topoisomerase IIalpha
about
DNA cleavage and opening reactions of human topoisomerase IIα are regulated via Mg2+-mediated dynamic bending of gate-DNAA novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerasesStructure of a topoisomerase II–DNA–nucleotide complex reveals a new control mechanism for ATPase activityRecovery of the poisoned topoisomerase II for DNA religation: coordinated motion of the cleavage core revealed with the microsecond atomistic simulation.Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2).The use of divalent metal ions by type II topoisomerases.Sin resolvase catalytic activity and oligomerization state are tightly coupled.Interactions between the etoposide derivative F14512 and human type II topoisomerases: implications for the C4 spermine moiety in promoting enzyme-mediated DNA cleavageUse of divalent metal ions in the DNA cleavage reaction of topoisomerase IV.Etoposide quinone is a redox-dependent topoisomerase II poisonAmsacrine as a topoisomerase II poison: importance of drug-DNA interactions.Human topoisomerase IIalpha uses a two-metal-ion mechanism for DNA cleavage.The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothingArginine as a general acid catalyst in serine recombinase-mediated DNA cleavageUse of divalent metal ions in the dna cleavage reaction of human type II topoisomerases.The DNA-gate of Bacillus subtilis gyrase is predominantly in the closed conformation during the DNA supercoiling reaction.Metal ion interactions in the DNA cleavage/ligation active site of human topoisomerase IIalphaNicked-site substrates for a serine recombinase reveal enzyme-DNA communications and an essential tethering role of covalent enzyme-DNA linkages.DNA gyrase with a single catalytic tyrosine can catalyze DNA supercoiling by a nicking-closing mechanism.Coordinating the two protomer active sites of human topoisomerase IIalpha: nicks as topoisomerase II poisons.Coupling the core of the anticancer drug etoposide to an oligonucleotide induces topoisomerase II-mediated cleavage at specific DNA sequences.
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Using 3'-bridging phosphorothiolates to isolate the forward DNA cleavage reaction of human topoisomerase IIalpha
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 05 March 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Using 3'-bridging phosphorothi ...... of human topoisomerase IIalpha
@en
Using 3'-bridging phosphorothi ...... f human topoisomerase IIalpha.
@nl
type
label
Using 3'-bridging phosphorothi ...... of human topoisomerase IIalpha
@en
Using 3'-bridging phosphorothi ...... f human topoisomerase IIalpha.
@nl
prefLabel
Using 3'-bridging phosphorothi ...... of human topoisomerase IIalpha
@en
Using 3'-bridging phosphorothi ...... f human topoisomerase IIalpha.
@nl
P2093
P2860
P356
P1433
P1476
Using 3'-bridging phosphorothi ...... of human topoisomerase IIalpha
@en
P2093
Alex B Burgin
Joseph E Deweese
Neil Osheroff
P2860
P304
P356
10.1021/BI702194X
P407
P577
2008-03-05T00:00:00Z