Substituents on etoposide that interact with human topoisomerase IIalpha in the binary enzyme-drug complex: contributions to etoposide binding and activity.
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Targeting DNA topoisomerase II in cancer chemotherapyStructural basis of type II topoisomerase inhibition by the anticancer drug etoposideThe Structure of DNA-Bound Human Topoisomerase II Alpha: Conformational Mechanisms for Coordinating Inter-Subunit Interactions with DNA CleavageImportance of microbial natural products and the need to revitalize their discovery.Natural products as topoisomerase II poisons: effects of thymoquinone on DNA cleavage mediated by human topoisomerase IIαRelationship of DNA damage signaling to DNA replication following treatment with DNA topoisomerase inhibitors camptothecin/topotecan, mitoxantrone, or etoposideCdt1 is differentially targeted for degradation by anticancer chemotherapeutic drugs.Catalytic core of human topoisomerase IIα: insights into enzyme-DNA interactions and drug mechanismInteractions between the etoposide derivative F14512 and human type II topoisomerases: implications for the C4 spermine moiety in promoting enzyme-mediated DNA cleavageContributions of the D-Ring to the activity of etoposide against human topoisomerase IIα: potential interactions with DNA in the ternary enzyme--drug--DNA complex.Etoposide quinone is a redox-dependent topoisomerase II poisonActivity of quinolone CP-115,955 against bacterial and human type II topoisomerases is mediated by different interactions.Amsacrine as a topoisomerase II poison: importance of drug-DNA interactions.The efficacy of topoisomerase II-targeted anticancer agents reflects the persistence of drug-induced cleavage complexes in cellsPhytochemicals as Anticancer and Chemopreventive Topoisomerase II Poisons.Long-term effects of chromatin remodeling and DNA damage in stem cells induced by environmental and dietary agents.Common Chemical Inductors of Replication Stress: Focus on Cell-Based Studies.Natural products for cancer chemotherapy.Neoamphimedine circumvents metnase-enhanced DNA topoisomerase IIα activity through ATP-competitive inhibitionEtoposide quinone is a covalent poison of human topoisomerase IIβ.An optimized polyamine moiety boosts the potency of human type II topoisomerase poisons as quantified by comparative analysis centered on the clinical candidate F14512.Coupling the core of the anticancer drug etoposide to an oligonucleotide induces topoisomerase II-mediated cleavage at specific DNA sequences.
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P2860
Substituents on etoposide that interact with human topoisomerase IIalpha in the binary enzyme-drug complex: contributions to etoposide binding and activity.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 21 March 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Substituents on etoposide that ...... toposide binding and activity.
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Substituents on etoposide that ...... toposide binding and activity.
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type
label
Substituents on etoposide that ...... toposide binding and activity.
@en
Substituents on etoposide that ...... toposide binding and activity.
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prefLabel
Substituents on etoposide that ...... toposide binding and activity.
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Substituents on etoposide that ...... toposide binding and activity.
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P2093
P2860
P356
P1433
P1476
Substituents on etoposide that ...... etoposide binding and activity
@en
P2093
David E Graves
Ian Romaine
Michael J Jablonksy
Mohammad Shadid
Neil Osheroff
Norma Dunlap
Ryan P Bender
P2860
P304
P356
10.1021/BI702019Z
P407
P577
2008-03-21T00:00:00Z