Etoposide targets topoisomerase IIalpha and IIbeta in leukemic cells: isoform-specific cleavable complexes visualized and quantified in situ by a novel immunofluorescence technique.
about
Bioflavonoids as poisons of human topoisomerase II alpha and II betaCollision of Trapped Topoisomerase 2 with Transcription and Replication: Generation and Repair of DNA Double-Strand Breaks with 5' AdductsDrugging topoisomerases: lessons and challengesThe Structure of DNA-Bound Human Topoisomerase II Alpha: Conformational Mechanisms for Coordinating Inter-Subunit Interactions with DNA CleavageReplication-dependent and transcription-dependent mechanisms of DNA double-strand break induction by the topoisomerase 2-targeting drug etoposideMyeloperoxidase Enhances Etoposide and Mitoxantrone-Mediated DNA Damage: A Target for Myeloprotection in Cancer ChemotherapyDrug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin.Novel acridine-based compounds that exhibit an anti-pancreatic cancer activity are catalytic inhibitors of human topoisomerase II.DNA break mapping reveals topoisomerase II activity genome-wide.Poly(ADP-ribose) polymerases PARP1 and PARP2 modulate topoisomerase II beta (TOP2B) function during chromatin condensation in mouse spermiogenesis.Histone deacetylase inhibition redistributes topoisomerase IIβ from heterochromatin to euchromatinGeminin overexpression prevents the completion of topoisomerase IIα chromosome decatenation, leading to aneuploidy in human mammary epithelial cellsRoles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies.Model for MLL translocations in therapy-related leukemia involving topoisomerase IIβ-mediated DNA strand breaks and gene proximity.MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA.A Novel Inhibitor of Topoisomerase I Is Selectively Toxic for a Subset of Non-Small Cell Lung Cancer Cell Lines.Mechanisms of Action and Reduced Cardiotoxicity of Pixantrone; a Topoisomerase II Targeting Agent with Cellular Selectivity for the Topoisomerase IIα Isoform.Schedule-dependent response of neuroblastoma cell lines to combinations of etoposide and cisplatin.A rapid and sensitive assay for DNA-protein covalent complexes in living cellsThe efficacy of topoisomerase II-targeted anticancer agents reflects the persistence of drug-induced cleavage complexes in cellsThe DNA cleavage reaction of topoisomerase II: wolf in sheep's clothingUse of divalent metal ions in the dna cleavage reaction of human type II topoisomerases.Proteasomal inhibition potentiates drugs targeting DNA topoisomerase II.Rac1 protein signaling is required for DNA damage response stimulated by topoisomerase II poisons.NK314, a topoisomerase II inhibitor that specifically targets the alpha isoform.Supervised classification of etoposide-treated in vitro adherent cells based on noninvasive imaging morphology.Human topoisomerase IIalpha: targeting to subchromosomal sites of activity during interphase and mitosis.Topoisomerase IIalpha-dependent induction of a persistent DNA damage response in response to transient etoposide exposure.Role of Topoisomerase IIβ in DNA Damage Response following IR and Etoposide.Chemo-sensitisation of HeLa cells to etoposide by a benzoxazine in the absence of DNA-PK inhibition.Cell death mechanisms of the anti-cancer drug etoposide on human cardiomyocytes isolated from pluripotent stem cells.TOP2B: The First Thirty Years
P2860
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P2860
Etoposide targets topoisomerase IIalpha and IIbeta in leukemic cells: isoform-specific cleavable complexes visualized and quantified in situ by a novel immunofluorescence technique.
description
1998 nî lūn-bûn
@nan
1998 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Etoposide targets topoisomeras ...... immunofluorescence technique.
@ast
Etoposide targets topoisomeras ...... immunofluorescence technique.
@en
type
label
Etoposide targets topoisomeras ...... immunofluorescence technique.
@ast
Etoposide targets topoisomeras ...... immunofluorescence technique.
@en
prefLabel
Etoposide targets topoisomeras ...... immunofluorescence technique.
@ast
Etoposide targets topoisomeras ...... immunofluorescence technique.
@en
P2093
P921
P1476
Etoposide targets topoisomeras ...... immunofluorescence technique.
@en
P2093
P577
1998-07-01T00:00:00Z