Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies. - Wikidata - awgldk - TriplyDB

Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies.

Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies.

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Genistein induces topoisomerase IIbeta- and proteasome-mediated DNA sequence rearrangements: Implications in infant leukemia (-)-Epigallocatechin gallate, a major constituent of green tea, poisons human type II topoisomerases Targeting DNA topoisomerase II in cancer chemotherapy Collision of Trapped Topoisomerase 2 with Transcription and Replication: Generation and Repair of DNA Double-Strand Breaks with 5' Adducts Molecular mechanisms of etoposide Drugging topoisomerases: lessons and challenges Structural basis of type II topoisomerase inhibition by the anticancer drug etoposide The Structure of DNA-Bound Human Topoisomerase II Alpha: Conformational Mechanisms for Coordinating Inter-Subunit Interactions with DNA Cleavage On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs Proteolytic Degradation of Topoisomerase II (Top2) Enables the Processing of Top2{middle dot}DNA and Top2{middle dot}RNA Covalent Complexes by Tyrosyl-DNA-Phosphodiesterase 2 (TDP2)Topoisomerase II-mediated DNA damage is differently repaired during the cell cycle by non-homologous end joining and homologous recombination The broken MLL gene is frequently located outside the inherent chromosome territory in human lymphoid cells treated with DNA topoisomerase II poison etoposide Replication-dependent and transcription-dependent mechanisms of DNA double-strand break induction by the topoisomerase 2-targeting drug etoposide Novel DNA topoisomerase IIα inhibitors from combined ligand- and structure-based virtual screening Phosphorylated Ribosomal Protein S6 Is Required for Akt-Driven Hyperplasia and Malignant Transformation, but Not for Hypertrophy, Aneuploidy and Hyperfunction of Pancreatic β-Cells Myeloperoxidase Enhances Etoposide and Mitoxantrone-Mediated DNA Damage: A Target for Myeloprotection in Cancer Chemotherapy G9a inhibition potentiates the anti-tumour activity of DNA double-strand break inducing agents by impairing DNA repair independent of p53 status Recovery of the poisoned topoisomerase II for DNA religation: coordinated motion of the cleavage core revealed with the microsecond atomistic simulation.Novel acridine-based compounds that exhibit an anti-pancreatic cancer activity are catalytic inhibitors of human topoisomerase II.Anti-cancer agents in Saudi Arabian herbals revealed by automated high-content imaging.Maternal topoisomerase II alpha, not topoisomerase II beta, enables embryonic development of zebrafish top2a-/- mutants.Molecular analysis of t(15;17) genomic breakpoints in secondary acute promyelocytic leukemia arising after treatment of multiple sclerosis Efficacy of substituted 9-aminoacridine derivatives in small cell lung cancer.Novel mechanism by which histone deacetylase inhibitors facilitate topoisomerase IIα degradation in hepatocellular carcinoma cells Interactions between the etoposide derivative F14512 and human type II topoisomerases: implications for the C4 spermine moiety in promoting enzyme-mediated DNA cleavage Oral squamous cell carcinoma in a patient treated with long-term pegylated liposomal doxorubicin for recurrent ovarian cancer.Contributions of the D-Ring to the activity of etoposide against human topoisomerase IIα: potential interactions with DNA in the ternary enzyme--drug--DNA complex.Transcription-induced DNA double strand breaks: both oncogenic force and potential therapeutic target?Fibroblast growth factor receptor 4 protein expression and clinicopathological features in gastric cancer.DNA-dependent protein kinase and ataxia telangiectasia mutated (ATM) promote cell survival in response to NK314, a topoisomerase IIα inhibitor.An improved high yield total synthesis and cytotoxicity study of the marine alkaloid neoamphimedine: an ATP-competitive inhibitor of topoisomerase IIα and potent anticancer agent.Dietary isothiocyanate-induced apoptosis via thiol modification of DNA topoisomerase IIα.Unravelling the genomic targets of small molecules using high-throughput sequencing.High TOP2B/TOP2A expression ratio at diagnosis correlates with favourable outcome for standard chemotherapy in acute myeloid leukaemia.Anti-proliferative effects of simocyclinone D8 (SD8), a novel catalytic inhibitor of topoisomerase II.Mangiferin activates Nrf2-antioxidant response element signaling without reducing the sensitivity to etoposide of human myeloid leukemia cells in vitro.Mining expression and prognosis of topoisomerase isoforms in non-small-cell lung cancer by using Oncomine and Kaplan-Meier plotter Interlinked DNA nano-circles for measuring topoisomerase II activity at the level of single decatenation events.Squamous cell carcinoma of the oral cavity in nonsmoking women: a new and unusual complication of chemotherapy for recurrent ovarian cancer?The dual topoisomerase inhibitor A35 preferentially and specially targets topoisomerase 2α by enhancing pre-strand and post-strand cleavage and inhibiting DNA religation

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Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies.

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Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies.

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Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies.

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Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies.

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Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies.

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Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies.

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Proceedings of the National Academy of Sciences of the United States of America

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Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies

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Anna M Azarova

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Chao-Po Lin

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James C Wang

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Johnson Yiu-Nam Lau

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Yi Lisa Lyu

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Yuan-Chin Tsai

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P2860

Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias

Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias

Sonic hedgehog regulates growth and morphogenesis of the tooth

Genetic pathways in therapy-related myelodysplasia and acute myeloid leukemia

Aberrant lamination in the cerebral cortex of mouse embryos lacking DNA topoisomerase IIbeta

Immunohistochemical analyses of DNA topoisomerase II isoforms in developing rat cerebellum

Differential expressions of the topoisomerase II alpha and II beta mRNAs in developing rat brain

Etoposide metabolites enhance DNA topoisomerase II cleavage near leukemia-associated MLL translocation breakpoints.

Etoposide targets topoisomerase IIalpha and IIbeta in leukemic cells: isoform-specific cleavable complexes visualized and quantified in situ by a novel immunofluorescence technique.

Cloning and sequencing of cDNA encoding human DNA topoisomerase II and localization of the gene to chromosome region 17q21-22

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