Molecular mechanism and functional significance of the MinK control of the KvLQT1 channel activity. - Wikidata - awgldk - TriplyDB

Molecular mechanism and functional significance of the MinK control of the KvLQT1 channel activity.

Molecular mechanism and functional significance of the MinK control of the KvLQT1 channel activity.

http://www.wikidata.org/entity/Q33175234

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Pacemaker channel dysfunction in a patient with sinus node disease Properties of KvLQT1 K+ channel mutations in Romano-Ward and Jervell and Lange-Nielsen inherited cardiac arrhythmias Functional expression of two KvLQT1-related potassium channels responsible for an inherited idiopathic epilepsy KCNE4 is an inhibitory subunit to Kv1.1 and Kv1.3 potassium channels.A functional-phylogenetic classification system for transmembrane solute transporters KCNE4 is an inhibitory subunit to the KCNQ1 channel Voltage-dependent inactivation of the human K+ channel KvLQT1 is eliminated by association with minimal K+ channel (minK) subunits Inactivation as a new regulatory mechanism for neuronal Kv7 channels Driving with no brakes: molecular pathophysiology of Kv7 potassium channels Structure of KCNE1 and Implications for How It Modulates the KCNQ1 Potassium Channel † ‡Preparation, functional characterization, and NMR studies of human KCNE1, a voltage-gated potassium channel accessory subunit associated with deafness and long QT syndrome Evidence for KCNQ1 K+ channel expression in rat zymogen granule membranes and involvement in cholecystokinin-induced pancreatic acinar secretion Stoichiometry of the KCNQ1 - KCNE1 ion channel complex.Inherited long QT syndromes: a paradigm for understanding arrhythmogenesis.Differential modulations of KCNQ1 by auxiliary proteins KCNE1 and KCNE2 Overexpression of a human potassium channel suppresses cardiac hyperexcitability in rabbit ventricular myocytes.N-terminal arginines modulate plasma-membrane localization of Kv7.1/KCNE1 channel complexes.Activation and inactivation of homomeric KvLQT1 potassium channels.Pore- and state-dependent cadmium block of I(Ks) channels formed with MinK-55C and wild-type KCNQ1 subunits The KCNQ1 potassium channel: from gene to physiological function.Electrolyte transport in the mammalian colon: mechanisms and implications for disease.Allosteric features of KCNQ1 gating revealed by alanine scanning mutagenesis.Computational model of vectorial potassium transport by cochlear marginal cells and vestibular dark cells.Mutation in the S3 segment of KCNQ1 results in familial lone atrial fibrillation KCNQ1/KCNE1 assembly, co-translation not required.Insights into the molecular mechanisms of bradycardia-triggered arrhythmias in long QT-3 syndrome KCNE1 enhances phosphatidylinositol 4,5-bisphosphate (PIP2) sensitivity of IKs to modulate channel activity.Distinct gene-specific mechanisms of arrhythmia revealed by cardiac gene transfer of two long QT disease genes, HERG and KCNE1.Single-channel properties of IKs potassium channels.Single-channel characteristics of wild-type IKs channels and channels formed with two minK mutants that cause long QT syndrome.MinK subdomains that mediate modulation of and association with KvLQT1.Single-channel basis for the slow activation of the repolarizing cardiac potassium current, I(Ks)Functional expression of KCNQ (Kv7) channels in guinea pig bladder smooth muscle and their contribution to spontaneous activity.The voltage-gated channel accessory protein KCNE2: multiple ion channel partners, multiple ways to long QT syndrome.The KCNE Tango - How KCNE1 Interacts with Kv7.1.Trafficking of the IKs -complex in MDCK cells: site of subunit assembly and determinants of polarized localization.Genetic screening in C. elegans identifies rho-GTPase activating protein 6 as novel HERG regulator.KCNE1 subunits require co-assembly with K+ channels for efficient trafficking and cell surface expression.TEA(+)-sensitive KCNQ1 constructs reveal pore-independent access to KCNE1 in assembled I(Ks) channels.Desensitization of chemical activation by auxiliary subunits: convergence of molecular determinants critical for augmenting KCNQ1 potassium channels.

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P2860

Molecular mechanism and functional significance of the MinK control of the KvLQT1 channel activity.

http://www.wikidata.org/entity/Q33175234

description

1997 nî lūn-bûn

@nan

1997 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

1997 թվականի հուլիսին հրատարակված գիտական հոդված

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1997年の論文

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1997年論文

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1997年論文

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1997年論文

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1997年論文

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1997年論文

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1997年论文

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name

Molecular mechanism and functi ...... f the KvLQT1 channel activity.

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Molecular mechanism and functi ...... f the KvLQT1 channel activity.

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type

label

Molecular mechanism and functi ...... f the KvLQT1 channel activity.

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Molecular mechanism and functi ...... f the KvLQT1 channel activity.

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prefLabel

Molecular mechanism and functi ...... f the KvLQT1 channel activity.

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Molecular mechanism and functi ...... f the KvLQT1 channel activity.

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Journal of Biological Chemistry

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Molecular mechanism and functi ...... f the KvLQT1 channel activity.

@en

P2093

Abitbol I

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Attali B

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Barhanin J

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Chouabe C

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Guillemare E

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Lazdunski M

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Romey G

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P2860

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias

Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel

A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange-Nielsen cardioauditory syndrome

Cloning of a membrane protein that induces a slow voltage-gated potassium current

K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current

Mutations in the K+ channel signature sequence.

Inner ear defects induced by null mutation of the isk gene.

Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents.

Gating of IsK expressed in Xenopus oocytes depends on the amount of mRNA injected.

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16713-16716

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272

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9201970

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