Insights into the molecular mechanisms of bradycardia-triggered arrhythmias in long QT-3 syndrome
about
Molecular basis of ranolazine block of LQT-3 mutant sodium channels: evidence for site of actionThe role of late I Na in development of cardiac arrhythmiasA novel and lethal de novo LQT-3 mutation in a newborn with distinct molecular pharmacology and therapeutic responseSpectrum of cardiac manifestations from aconitine poisoning.Autonomic modulation and antiarrhythmic therapy in a model of long QT syndrome type 3Irregularly appearing early afterdepolarizations in cardiac myocytes: random fluctuations or dynamical chaos?Mechanisms and determinants of ultralong action potential duration and slow rate-dependence in cardiac myocytes.Calcium-voltage coupling in the genesis of early and delayed afterdepolarizations in cardiac myocytesAltered Na+ channels promote pause-induced spontaneous diastolic activity in long QT syndrome type 3 myocytes.Pharmacogenetics and anti-arrhythmic drug therapy: a theoretical investigation.Synchronization of early afterdepolarizations and arrhythmogenesis in heterogeneous cardiac tissue models.Simulation of Ca-calmodulin-dependent protein kinase II on rabbit ventricular myocyte ion currents and action potentials.The Na+ channel inactivation gate is a molecular complex: a novel role of the COOH-terminal domain.Computational approaches to understand cardiac electrophysiology and arrhythmias.Ca2+/calmodulin-dependent protein kinase II-based regulation of voltage-gated Na+ channel in cardiac disease.Pathophysiology of the cardiac late Na current and its potential as a drug target.The arrhythmogenic consequences of increasing late INa in the cardiomyocyte.Ranolazine for congenital and acquired late INa-linked arrhythmias: in silico pharmacological screening.Deranged sodium to sudden death.Revealing the Concealed Nature of Long-QT Type 3 Syndrome.Quantifying the origins of population variability in cardiac electrical activity through sensitivity analysis of the electrocardiogram.Long-QT syndrome-related sodium channel mutations probed by the dynamic action potential clamp technique.Molecular determinants of local anesthetic action of beta-blocking drugs: Implications for therapeutic management of long QT syndrome variant 3Differential modulation of late sodium current by protein kinase A in R1623Q mutant of LQT3.Structural effects of an LQT-3 mutation on heart Na+ channel gating.Theoretical investigation of the neuronal Na+ channel SCN1A: abnormal gating and epilepsy.Na(+) channel I-II loop mediates parallel genetic and phosphorylation-dependent gating changesIntracellular calcium attenuates late current conducted by mutant human cardiac sodium channels.Induced pluripotent stem cells used to reveal drug actions in a long QT syndrome family with complex genetics.Multiscale cardiac modelling reveals the origins of notched T waves in long QT syndrome type 2.The human Nav1.5 F1486 deletion associated with long QT syndrome leads to impaired sodium channel inactivation and reduced lidocaine sensitivity.An increase of late sodium current induces delayed afterdepolarizations and sustained triggered activity in atrial myocytes.Computer model of action potential of mouse ventricular myocytes.Regulation of Cardiac Voltage-Gated Sodium Channel by Kinases: Roles of Protein Kinases A and C.A computational model of Purkinje fibre single cell electrophysiology: implications for the long QT syndrome.In silico assessment of Y1795C and Y1795H SCN5A mutations: implication for inherited arrhythmogenic syndromesA Heart for Diversity: Simulating Variability in Cardiac Arrhythmia Research
P2860
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P2860
Insights into the molecular mechanisms of bradycardia-triggered arrhythmias in long QT-3 syndrome
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2002 nî lūn-bûn
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2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի նոյեմբերին հրատարակված գիտական հոդված
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2002年の論文
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2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
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name
Insights into the molecular me ...... hythmias in long QT-3 syndrome
@ast
Insights into the molecular me ...... hythmias in long QT-3 syndrome
@en
Insights into the molecular me ...... hythmias in long QT-3 syndrome
@nl
type
label
Insights into the molecular me ...... hythmias in long QT-3 syndrome
@ast
Insights into the molecular me ...... hythmias in long QT-3 syndrome
@en
Insights into the molecular me ...... hythmias in long QT-3 syndrome
@nl
prefLabel
Insights into the molecular me ...... hythmias in long QT-3 syndrome
@ast
Insights into the molecular me ...... hythmias in long QT-3 syndrome
@en
Insights into the molecular me ...... hythmias in long QT-3 syndrome
@nl
P2860
P1476
Insights into the molecular me ...... hythmias in long QT-3 syndrome
@en
P2093
Colleen E Clancy
Robert S Kass
P2860
P304
P356
10.1172/JCI0215928
10.1172/JCI15928
P407
P50
P577
2002-11-01T00:00:00Z