Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi.
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Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug DesignFunctional analysis of the cathepsin-like cysteine protease genes in adult Brugia malayi using RNA interferenceMining a cathepsin inhibitor library for new antiparasitic drug leadsCrystal structures of crotonaldehyde semicarbazone and crotonaldehyde thiosemicarbazone from X-ray powder diffraction data.Two approaches to discovering and developing new drugs for Chagas disease.Assessing the trypanocidal potential of natural and semi-synthetic diketopiperazines from two deep water marine-derived fungi.(E)-3-(2-{2-[1-(3-Hy-droxy-phen-yl)ethyl-idene]hydrazin-yl}-1,3-thia-zol-4-yl)-2H-chromen-2-one.Synthesis of a sugar-based thiosemicarbazone series and structure-activity relationship versus the parasite cysteine proteases rhodesain, cruzain, and Schistosoma mansoni cathepsin B1.(2E)-2-[(3E)-4-Phenyl-but-3-en-2-yl-idene]hydrazinecarboxamide.Crystal structure of [(E)-({2-[3-(2-{(1E)-[(carbamo-thioyl-amino)-imino]-meth-yl}phen-oxy)prop-oxy]phen-yl}methyl-idene)amino]-thio-urea with an unknown solvateChemically modified peptides targeting the PDZ domain of GIPC as a therapeutic approach for cancer.Novel antitrypanosomal agents.Synthesis, Structure and Antioxidant Activity of (Tetra-O-acetyl-β-D-galactopyranosyl)thiosemicarbazones of Substituted BenzaldehydesChemical-biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target.Synthesis and biochemical evaluation of benzoylbenzophenone thiosemicarbazone analogues as potent and selective inhibitors of cathepsin L.Crystal structure of 3-[(E)-(2-hy-droxy-3-meth-oxy-benzyl-idene)amino]-1-methyl-1-phenyl-thio-urea.Structure-guided development of selective TbcatB inhibitorsReversible cysteine protease inhibitors show promise for a Chagas disease cure.Trypanocidal drugs: mechanisms, resistance and new targets.Use of cysteine-reactive small molecules in drug discovery for trypanosomal disease.Lead Optimization of 2-Cyclohexyl-N-[(Z)-(3-methoxyphenyl/3-hydroxyphenyl) methylidene]hydrazinecarbothioamides for Targeting the HER-2 Overexpressed Breast Cancer Cell Line SKBr-3.Synthesis, X-ray structure and in vitro cytotoxicity studies of Cu(I/II) complexes of thiosemicarbazone: special emphasis on their interactions with DNA.Improved antiparasitic activity by incorporation of organosilane entities into half-sandwich ruthenium(II) and rhodium(III) thiosemicarbazone complexes.Synthesis and Antimycobacterial Activity of some Triazole Derivatives-New Route to Functionalized TriazolopyridazinesUnravelling mechanisms behind the biological activity of bis(S-citronellalthiosemicarbazonato)nickel(II).Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB2-(3,4-dihydro-4-oxothieno[2,3-d]pyrimidin-2-ylthio) acetamides as a new class of falcipain-2 inhibitors. 3. design, synthesis and biological evaluation.Analysis of non-peptidic compounds as potential malarial inhibitors against Plasmodial cysteine proteases via integrated virtual screening workflow.Antimalarial activity of thiosemicarbazones and purine derived nitriles.Role of the Trypanosoma brucei natural cysteine peptidase inhibitor ICP in differentiation and virulence.5-Nitroisatin-derived thiosemicarbazones: potential antileishmanial agents.2-amido-3-(1H-indol-3-yl)-N-substituted-propanamides as a new class of falcipain-2 inhibitors. 1. Design, synthesis, biological evaluation and binding model studies.Potential mechanism of the anti-trypanosomal activity of organoruthenium complexes with bioactive thiosemicarbazones.Structural improvement of new thiazolidinones compounds with antinociceptive activity in experimental chemotherapy-induced painful neuropathy.Synthesis and antimicrobial studies of novel 2,4-diaryl-3-azabicyclo[3.3.1]nonan-9-one 4'-phenylthiosemicarbazones.Water-soluble ruthenium complexes bearing activity against protozoan parasites.Sulfonamide-Linked Ciprofloxacin, Sulfadiazine and Amantadine Derivatives as a Novel Class of Inhibitors of Jack Bean Urease; Synthesis, Kinetic Mechanism and Molecular Docking.The interplay of solvation, molecular conformation and supramolecular assembly in 1,1'-({[(ethane-1,2-diyl)dioxy](1,2-phenylene)}bis(methanylylidene))bis(thiosemicarbazide) and its N,N-dimethylformamide disolvate.Structural design, synthesis and structure-activity relationships of thiazolidinones with enhanced anti-Trypanosoma cruzi activity.Reactions of carbon disulfide with N-nucleophiles
P2860
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P2860
Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi.
description
2004 nî lūn-bûn
@nan
2004 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Synthesis and structure-activi ...... brucei, and Trypanosoma cruzi.
@ast
Synthesis and structure-activi ...... brucei, and Trypanosoma cruzi.
@en
type
label
Synthesis and structure-activi ...... brucei, and Trypanosoma cruzi.
@ast
Synthesis and structure-activi ...... brucei, and Trypanosoma cruzi.
@en
prefLabel
Synthesis and structure-activi ...... brucei, and Trypanosoma cruzi.
@ast
Synthesis and structure-activi ...... brucei, and Trypanosoma cruzi.
@en
P2093
P50
P921
P356
P1476
Synthesis and structure-activi ...... brucei, and Trypanosoma cruzi.
@en
P2093
Conor R Caffrey
Doron C Greenbaum
Elizabeth Hansell
Julia Lehrman
Patricia Doyle
P304
P356
10.1021/JM030549J
P407
P577
2004-06-01T00:00:00Z