Two approaches to discovering and developing new drugs for Chagas disease. - Wikidata - awgldk - TriplyDB

Two approaches to discovering and developing new drugs for Chagas disease.

Two approaches to discovering and developing new drugs for Chagas disease.

http://www.wikidata.org/entity/Q33503274

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Management of trypanosomiasis and leishmaniasis Novel amidines and analogues as promising agents against intracellular parasites: a systematic review Nonpeptidic Tetrafluorophenoxymethyl Ketone Cruzain Inhibitors as Promising New Leads for Chagas Disease Chemotherapy Structural Characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei Bound to the Antifungal Drugs Posaconazole and Fluconazole Structural Basis for Inhibition of Cathepsin B Drug Target from the Human Blood Fluke, Schistosoma mansoni Non-peptidic cruzain inhibitors with trypanocidal activity discovered by virtual screening and in vitro assay 4-Aminopyridyl-Based CYP51 Inhibitors as Anti- Trypanosoma cruzi Drug Leads with Improved Pharmacokinetic Profile and in Vivo Potency Computational identification of uncharacterized cruzain binding sites The Trypanosoma cruzi protease cruzain mediates immune evasion Combined treatment of heterocyclic analogues and benznidazole upon Trypanosoma cruzi in vivo Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51 A global comparison of the human and T. brucei degradomes gives insights about possible parasite drug targets Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease Identification of Trypanocidal Activity for Known Clinical Compounds Using a New Trypanosoma cruzi Hit-Discovery Screening Cascade.Image-based high-throughput drug screening targeting the intracellular stage of Trypanosoma cruzi, the agent of Chagas' disease.The centennial of the discovery of Chagas disease: facing the current challenges Screening of Potential anti-Trypanosoma cruzi Candidates: In Vitro and In Vivo Studies.Dialkylimidazole inhibitors of Trypanosoma cruzi sterol 14α-demethylase as anti-Chagas disease agents Arylimidamide DB766, a potential chemotherapeutic candidate for Chagas' disease treatment Functional studies of Plasmodium falciparum dipeptidyl aminopeptidase I using small molecule inhibitors and active site probes Calpains: potential targets for alternative chemotherapeutic intervention against human pathogenic trypanosomatids Repertoire, genealogy and genomic organization of cruzipain and homologous genes in Trypanosoma cruzi, T. cruzi-like and other trypanosome species.Cruzipain promotes Trypanosoma cruzi adhesion to Rhodnius prolixus midgut Genetic dissection of drug resistance in trypanosomes Development of a New Antileishmanial Aziridine-2,3-Dicarboxylate-Based Inhibitor with High Selectivity for Parasite Cysteine Proteases.Binding mode and potency of N-indolyloxopyridinyl-4-aminopropanyl-based inhibitors targeting Trypanosoma cruzi CYP51.Experimental Chemotherapy for Chagas Disease: A Morphological, Biochemical, and Proteomic Overview of Potential Trypanosoma cruzi Targets of Amidines Derivatives and Naphthoquinones.Synthesis of a sugar-based thiosemicarbazone series and structure-activity relationship versus the parasite cysteine proteases rhodesain, cruzain, and Schistosoma mansoni cathepsin B1.Drug discovery for neglected tropical diseases at the Sandler Center.Three-dimensional structures in the design of therapeutics targeting parasitic protozoa: reflections on the past, present and future.Clinical aspects of Chagas disease and implications for novel therapies.Identification of non-peptidic cysteine reactive fragments as inhibitors of cysteine protease rhodesain Mapping inhibitor binding modes on an active cysteine protease via nuclear magnetic resonance spectroscopy Chemical-biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target.Advances in Chagas disease drug development: 2009-2010 Reversible cysteine protease inhibitors show promise for a Chagas disease cure.Current developments in the therapy of protozoan infections.Synthetic Medicinal Chemistry in Chagas' Disease: Compounds at The Final Stage of "Hit-To-Lead" Phase.Multiple Cathepsins Promote Pro-IL-1β Synthesis and NLRP3-Mediated IL-1β Activation "Manifesto" for advancing the control and elimination of neglected tropical diseases.

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Two approaches to discovering and developing new drugs for Chagas disease.

http://www.wikidata.org/entity/Q33503274

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2009 nî lūn-bûn

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2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2009 թվականի հուլիսին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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Two approaches to discovering and developing new drugs for Chagas disease.

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Two approaches to discovering and developing new drugs for Chagas disease.

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Two approaches to discovering and developing new drugs for Chagas disease.

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Two approaches to discovering and developing new drugs for Chagas disease.

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Two approaches to discovering and developing new drugs for Chagas disease.

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Two approaches to discovering and developing new drugs for Chagas disease.

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Memórias do Instituto Oswaldo Cruz

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Two approaches to discovering and developing new drugs for Chagas disease

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C S Craik

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I D Kerr

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J C Engel

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J H McKerrow

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L M Podust

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L S Brinen

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M Arkin

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P S Doyle

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R Ferreira

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S A Robertson

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P2860

Cysteine protease inhibitors cure an experimental Trypanosoma cruzi infection

A cysteine protease inhibitor cures Chagas' disease in an immunodeficient-mouse model of infection

Crystal structure of cytochrome P450 14 -sterol demethylase (CYP51) from Mycobacterium tuberculosis in complex with azole inhibitors

Small-Molecule Scaffolds for CYP51 Inhibitors Identified by High-Throughput Screening and Defined by X-Ray Crystallography

X-ray Structure of 4,4'-Dihydroxybenzophenone Mimicking Sterol Substrate in the Active Site of Sterol 14 -Demethylase (CYP51)

Trypanosoma cruzi CYP51 Inhibitor Derived from a Mycobacterium tuberculosis Screen Hit

A critical review on Chagas disease chemotherapy

Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi.

Bis-acridines as lead antiparasitic agents: structure-activity analysis of a discrete compound library in vitro.

Identification of a new class of nonpeptidic inhibitors of cruzain.

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10.1590/S0074-02762009000900034

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104 Suppl 1

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