Hsp90 inhibitors identified from a library of novobiocin analogues.
about
The 'active life' of Hsp90 complexesProtein homeostasis as a therapeutic target for diseases of protein conformationFunctions of the Hsp90 chaperone system: lifting client proteins to new heightsHeat shock transcription factor 1 as a therapeutic target in neurodegenerative diseasesElucidation of the Hsp90 C-terminal inhibitor binding siteMarine sediment-derived Streptomyces bacteria from British Columbia, Canada are a promising microbiota resource for the discovery of antimicrobial natural productsCompound ranking based on a new mathematical measure of effectiveness using time course data from cell-based assays.Development and characterization of a novel C-terminal inhibitor of Hsp90 in androgen dependent and independent prostate cancer cells.Optimizing glycosyltransferase specificity via "hot spot" saturation mutagenesis presents a catalyst for novobiocin glycorandomization.The synthesis and evaluation of flavone and isoflavone chimeras of novobiocin and derruboneGambogic acid, a natural product inhibitor of Hsp90Novobiocin analogues with second-generation noviose surrogates.Probing molecular mechanisms of the Hsp90 chaperone: biophysical modeling identifies key regulators of functional dynamics.3-Arylcoumarin derivatives manifest anti-proliferative activity through Hsp90 inhibition.3D-QSAR Assisted Design, Synthesis and Evaluation of Novobiocin Analogues.Development of a high-throughput screening cancer cell-based luciferase refolding assay for identifying Hsp90 inhibitors.Engineering an antibiotic to fight cancer: optimization of the novobiocin scaffold to produce anti-proliferative agents.Novologues containing a benzamide side chain manifest anti-proliferative activity against two breast cancer cell lines.Design, synthesis, and biological evaluation of ring-constrained novobiocin analogues as hsp90 C-terminal inhibitorsA systematic protocol for the characterization of Hsp90 modulators.Targeting chaperones in transformed systems--a focus on Hsp90 and cancer.Development of Noviomimetics as C-Terminal Hsp90 InhibitorsInhibitors of the heat shock response: biology and pharmacology.Synthesis and Biological Evaluation of Novobiocin Core Analogues as Hsp90 Inhibitors.Natural product inhibitors of Hsp90: potential leads for drug discoveryNovobiocin and additional inhibitors of the Hsp90 C-terminal nucleotide-binding pocket.Alternate strategies of Hsp90 modulation for the treatment of cancer and other diseases.Novel therapeutic strategies in multiple myeloma: role of the heat shock protein inhibitors.Coumarin-based drugs: a patent review (2008 -- present).Synthesis and Evaluation of Noviose Replacements on Novobiocin that Manifest Anti-proliferative Activity.Synthesis and biological evaluation of coumarin replacements of novobiocin as Hsp90 inhibitors.Targeting the heat shock protein 90 dimer with dimeric inhibitors.Design, synthesis and biological evaluation of alkylamino biphenylamides as Hsp90 C-terminal inhibitors.Anticancer Inhibitors of Hsp90 Function: Beyond the Usual Suspects.Development of radamide analogs as Grp94 inhibitorsCruentaren A binds F1F0 ATP synthase to modulate the Hsp90 protein folding machineryAlternative approaches to Hsp90 modulation for the treatment of cancer.Synthesis and biological evaluation of arylated novobiocin analogs as Hsp90 inhibitors.Click chemistry to probe Hsp90: Synthesis and evaluation of a series of triazole-containing novobiocin analogues.A novel HSP90 modulator with selective activity against thyroid cancers in vitro
P2860
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P2860
Hsp90 inhibitors identified from a library of novobiocin analogues.
description
2005 nî lūn-bûn
@nan
2005 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Hsp90 inhibitors identified from a library of novobiocin analogues.
@ast
Hsp90 inhibitors identified from a library of novobiocin analogues.
@en
type
label
Hsp90 inhibitors identified from a library of novobiocin analogues.
@ast
Hsp90 inhibitors identified from a library of novobiocin analogues.
@en
prefLabel
Hsp90 inhibitors identified from a library of novobiocin analogues.
@ast
Hsp90 inhibitors identified from a library of novobiocin analogues.
@en
P2093
P356
P1476
Hsp90 inhibitors identified from a library of novobiocin analogues.
@en
P2093
Benjamin Cronk
Brian S J Blagg
Helen Blake
Jeff Holzbeierlein
Len Neckers
Xiao Ming Yu
P304
12778-12779
P356
10.1021/JA0535864
P407
P577
2005-09-01T00:00:00Z