Resistance of Streptococcus pneumoniae to deformylase inhibitors is due to mutations in defB.
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An unusual peptide deformylase features in the human mitochondrial N-terminal methionine excision pathwayHuman mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibioticsFmt bypass in Pseudomonas aeruginosa causes induction of MexXY efflux pump expressionThe Pseudomonas aeruginosa initiation factor IF-2 is responsible for formylation-independent protein initiation in P. aeruginosaPeptide deformylase inhibitors as antibacterial agents: identification of VRC3375, a proline-3-alkylsuccinyl hydroxamate derivative, by using an integrated combinatorial and medicinal chemistry approach.Reduced susceptibility of Haemophilus influenzae to the peptide deformylase inhibitor LBM415 can result from target protein overexpression due to amplified chromosomal def gene copy number.Comparative antimicrobial characterization of LBM415 (NVP PDF-713), a new peptide deformylase inhibitor of clinical importance.N-alkyl urea hydroxamic acids as a new class of peptide deformylase inhibitors with antibacterial activityReducing the fitness cost of antibiotic resistance by amplification of initiator tRNA genes.Efficacy of BB-83698, a novel peptide deformylase inhibitor, in a mouse model of pneumococcal pneumonia.Peptide deformylase inhibitors as potent antimycobacterial agents.Comparative genome analysis identifies two large deletions in the genome of highly-passaged attenuated Streptococcus agalactiae strain YM001 compared to the parental pathogenic strain HN016Determination of the core of a minimal bacterial gene setTherapeutic potential of peptide deformylase inhibitors.Peptide deformylase is a potential target for anti-Helicobacter pylori drugs: reverse docking, enzymatic assay, and X-ray crystallography validation.Drug forecast - the peptide deformylase inhibitors as antibacterial agents.Mutations in three distinct loci cause resistance to peptide deformylase inhibitors in Bacillus subtilis.The Inhibition and Resistance Mechanisms of Actinonin, Isolated from Marine Streptomyces sp. NHF165, against Vibrio anguillarum.A unique peptide deformylase platform to rationally design and challenge novel active compounds.Peptide deformylase--a promising therapeutic target for tuberculosis and antibacterial drug discovery.Potent sub-MIC effect of GSK1322322 and other peptide deformylase inhibitors on in vitro growth of Staphylococcus aureus.Lack of formylated methionyl-tRNA has pleiotropic effects on Bacillus subtilis.Characterization of a novel fucose-regulated promoter (PfcsK) suitable for gene essentiality and antibacterial mode-of-action studies in Streptococcus pneumoniae.Identification of regions involved in enzymatic stability of peptide deformylase of Mycobacterium tuberculosis.Comparative analysis of the antibacterial activity of a novel peptide deformylase inhibitor, GSK1322322.Frequency of Spontaneous Resistance to Peptide Deformylase Inhibitor GSK1322322 in Haemophilus influenzae, Staphylococcus aureus, Streptococcus pyogenes, and Streptococcus pneumoniae.Staphylococcus aureus formyl-methionyl transferase mutants demonstrate reduced virulence factor production and pathogenicityActivity of LBM415 compared to those of 11 other agents against Haemophilus species.Multistep resistance selection and postantibiotic-effect studies of the antipneumococcal activity of LBM415 compared to other agentsProteomic study of peptide deformylase inhibition in Streptococcus pneumoniae and Staphylococcus aureus.The gene fmt, encoding tRNAfMet-formyl transferase, is essential for normal growth of M. bovis, but not for viability.
P2860
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P2860
Resistance of Streptococcus pneumoniae to deformylase inhibitors is due to mutations in defB.
description
2001 nî lūn-bûn
@nan
2001 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Resistance of Streptococcus pn ...... s is due to mutations in defB.
@ast
Resistance of Streptococcus pn ...... s is due to mutations in defB.
@en
type
label
Resistance of Streptococcus pn ...... s is due to mutations in defB.
@ast
Resistance of Streptococcus pn ...... s is due to mutations in defB.
@en
prefLabel
Resistance of Streptococcus pn ...... s is due to mutations in defB.
@ast
Resistance of Streptococcus pn ...... s is due to mutations in defB.
@en
P2093
P2860
P1476
Resistance of Streptococcus pn ...... s is due to mutations in defB.
@en
P2093
Hackbarth C
Margolis P
P2860
P304
P356
10.1128/AAC.45.9.2432-2435.2001
P407
P577
2001-09-01T00:00:00Z