Conditional deletion of the Bcl-x gene from erythroid cells results in hemolytic anemia and profound splenomegaly.
about
The Bcl-2 apoptotic switch in cancer development and therapyGenetic ablation of Bcl-x attenuates invasiveness without affecting apoptosis or tumor growth in a mouse model of pancreatic neuroendocrine cancerLnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathwaysSox6 is necessary for efficient erythropoiesis in adult mice under physiological and anemia-induced stress conditionsBcl-xL prevents apoptosis of late-stage erythroblasts but does not mediate the antiapoptotic effect of erythropoietinNIX is required for programmed mitochondrial clearance during reticulocyte maturationTransgenic, inducible RNAi in megakaryocytes and platelets in mice.BCL-2 is dispensable for thrombopoiesis and platelet survivalInherited thrombocytopenia: novel insights into megakaryocyte maturation, proplatelet formation and platelet lifespan.Bim and Mcl-1 exert key roles in regulating JAK2V617F cell survival.Temporally and spatially controlled expression of transgenes in embryonic and adult tissues.Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cellsDirect regulation of BCL-2 by FLI-1 is involved in the survival of FLI-1-transformed erythroblastsEpithelial ablation of Bcl-XL increases sensitivity to oxygen without disrupting lung development.Stat5 regulates cellular iron uptake of erythroid cells via IRP-2 and TfR-1.Mcl-1 is essential for germinal center formation and B cell memoryImmortalization of erythroblasts by c-MYC and BCL-XL enables large-scale erythrocyte production from human pluripotent stem cellsDuring EPO or anemia challenge, erythroid progenitor cells transit through a selectively expandable proerythroblast poolProtein phosphatase 2A catalytic subunit α (PP2Acα) maintains survival of committed erythroid cells in fetal liver erythropoiesis through the STAT5 pathway.p21Cip1 protection against hyperoxia requires Bcl-XL and is uncoupled from its ability to suppress growthIneffective erythropoiesis with reduced red blood cell survival in serotonin-deficient miceUnrestrained erythroblast development in Nix-/- mice reveals a mechanism for apoptotic modulation of erythropoiesis.Contrasting dynamic responses in vivo of the Bcl-xL and Bim erythropoietic survival pathways.A unique role for Stat5 in recovery from acute anemia.Novel roles for KLF1 in erythropoiesis revealed by mRNA-seq.Loss of Bcl-x in Ph+ B-ALL increases cellular proliferation and does not inhibit leukemogenesisMcl-1 and Bcl-xL cooperatively maintain integrity of hepatocytes in developing and adult murine liverBH3-only protein bid participates in the Bcl-2 network in healthy liver cellsEPO receptor circuits for primary erythroblast survivalDecreased differentiation of erythroid cells exacerbates ineffective erythropoiesis in beta-thalassemiaPivotal role of Bcl-2 family proteins in the regulation of chondrocyte apoptosis.Bcl-x L increases mitochondrial fission, fusion, and biomass in neurons.The Bcl-2 homology domain 3 (BH3)-only proteins Bim and bid are functionally active and restrained by anti-apoptotic Bcl-2 family proteins in healthy liver.A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL)Bcl-xL anti-apoptotic network is dispensable for development and maintenance of CML but is required for disease progression where it represents a new therapeutic target.Islet beta-cells deficient in Bcl-xL develop but are abnormally sensitive to apoptotic stimuli.The antiapoptotic protein Bcl-xL negatively regulates the bone-resorbing activity of osteoclasts in mice.Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53Erythropoietin receptor response circuitsSox6, jack of all trades: a versatile regulatory protein in vertebrate development
P2860
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P2860
Conditional deletion of the Bcl-x gene from erythroid cells results in hemolytic anemia and profound splenomegaly.
description
2000 nî lūn-bûn
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2000 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
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2000 թվականի նոյեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年论文
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name
Conditional deletion of the Bc ...... mia and profound splenomegaly.
@ast
Conditional deletion of the Bc ...... mia and profound splenomegaly.
@en
Conditional deletion of the Bc ...... mia and profound splenomegaly.
@nl
type
label
Conditional deletion of the Bc ...... mia and profound splenomegaly.
@ast
Conditional deletion of the Bc ...... mia and profound splenomegaly.
@en
Conditional deletion of the Bc ...... mia and profound splenomegaly.
@nl
prefLabel
Conditional deletion of the Bc ...... mia and profound splenomegaly.
@ast
Conditional deletion of the Bc ...... mia and profound splenomegaly.
@en
Conditional deletion of the Bc ...... mia and profound splenomegaly.
@nl
P2093
P1433
P1476
Conditional deletion of the Bc ...... mia and profound splenomegaly.
@en
P2093
Broussard C
Hennighausen L
Riedlinger G
Rucker EB 3rd
Schwartzberg PL
Siebenlist U
P304
P407
P577
2000-11-01T00:00:00Z