A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication. - Wikidata - awgldk - TriplyDB

A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication.

A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication.

http://www.wikidata.org/entity/Q33375590

about

Targeting membrane-bound viral RNA synthesis reveals potent inhibition of diverse coronaviruses including the middle East respiratory syndrome virus Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes Broad-spectrum in vitro activity and in vivo efficacy of the antiviral protein griffithsin against emerging viruses of the family Coronaviridae From SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug design Severe Acute Respiratory Syndrome Coronavirus Papain-like Novel Protease Inhibitors: Design, Synthesis, Protein−Ligand X-ray Structure and Biological Evaluation Papain-Like Protease 1 from Transmissible Gastroenteritis Virus: Crystal Structure and Enzymatic Activity toward Viral and Cellular Substrates Discovery, synthesis, and structure-based optimization of a series of N-(tert-butyl)-2-(N-arylamido)-2-(pyridin-3-yl) acetamides (ML188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus (SARS-CoV)X-ray Structural and Biological Evaluation of a Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-like Proteases Structural basis for catalysis and ubiquitin recognition by the severe acute respiratory syndrome coronavirus papain-like protease Small molecule deubiquitinase inhibitors promote macrophage anti-infective capacity Protein Interferon-Stimulated Gene 15 Conjugation Delays but Does Not Overcome Coronavirus Proliferation in a Model of Fulminant Hepatitis Structural view and substrate specificity of papain-like protease from avian infectious bronchitis virus.A mouse model for Betacoronavirus subgroup 2c using a bat coronavirus strain HKU5 variant The SARS-coronavirus papain-like protease: structure, function and inhibition by designed antiviral compounds.Structure-based design, synthesis, and biological evaluation of a series of novel and reversible inhibitors for the severe acute respiratory syndrome-coronavirus papain-like protease.Deubiquitinating and interferon antagonism activities of coronavirus papain-like proteases.Deubiquitinating enzymes as promising drug targets for infectious diseases.Development and validation of a yeast high-throughput screen for inhibitors of Aβ₄₂ oligomerization.Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture.Coronavirus papain-like proteases negatively regulate antiviral innate immune response through disruption of STING-mediated signaling A chimeric virus-mouse model system for evaluating the function and inhibition of papain-like proteases of emerging coronaviruses Hepatitis E virus inhibits type I interferon induction by ORF1 products Coronaviruses resistant to a 3C-like protease inhibitor are attenuated for replication and pathogenesis, revealing a low genetic barrier but high fitness cost of resistance Proteasome inhibition in vivo promotes survival in a lethal murine model of severe acute respiratory syndrome.Murine coronavirus ubiquitin-like domain is important for papain-like protease stability and viral pathogenesis.Catalytic function and substrate specificity of the papain-like protease domain of nsp3 from the Middle East respiratory syndrome coronavirus.Synergistic inhibitor binding to the papain-like protease of human SARS coronavirus: mechanistic and inhibitor design implications.Development of inhibitors in the ubiquitination cascade.Sculpting the proteome with small molecules Pharmacological targets in the ubiquitin system offer new ways of treating cancer, neurodegenerative disorders and infectious diseases.A small molecule deubiquitinase inhibitor increases localization of inducible nitric oxide synthase to the macrophage phagosome and enhances bacterial killing SARS hCoV papain-like protease is a unique Lys48 linkage-specific di-distributive deubiquitinating enzyme Comparison of SARS and NL63 papain-like protease binding sites and binding site dynamics: inhibitor design implications X-ray Structural and Functional Studies of the Three Tandemly Linked Domains of Non-structural Protein 3 (nsp3) from Murine Hepatitis Virus Reveal Conserved Functions.Inhibitor recognition specificity of MERS-CoV papain-like protease may differ from that of SARS-CoV Assessing activity and inhibition of Middle East respiratory syndrome coronavirus papain-like and 3C-like proteases using luciferase-based biosensors.Therapies for coronaviruses. Part 2: Inhibitors of intracellular life cycle.DUBs at a glance.Cell-based antiviral screening against coronaviruses: developing virus-specific and broad-spectrum inhibitors Interferon-Stimulated Gene 15 in the Control of Cellular Responses to Genotoxic Stress.

P2860

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P2860

A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication.

http://www.wikidata.org/entity/Q33375590

description

2008 nî lūn-bûn

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2008 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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A noncovalent class of papain- ...... blocks SARS virus replication.

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Proceedings of the National Academy of Sciences of the United States of America

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A noncovalent class of papain- ...... blocks SARS virus replication.

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Arun K Ghosh

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Bellur S Prabhakar

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Jun Takayama

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Katrina Sleeman

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Kiira Ratia

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Melissa Coughlin

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Rima Chaudhuri

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Scott Pegan

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Surendranath Baliji

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Susan C Baker

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P2860

Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases

Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats

Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14

A new model for protein stereospecificity

Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde

Crystallographic structure at 1.6-A resolution of the human adenovirus proteinase in a covalent complex with its 11-amino-acid peptide cofactor: insights on a new fold

Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B

Structure of a herpesvirus-encoded cysteine protease reveals a unique class of deubiquitinating enzymes

Targeting ubiquitin specific proteases for drug discovery

Bats are natural reservoirs of SARS-like coronaviruses

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16119-16124

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10.1073/PNAS.0805240105

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42

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Andrew D. Mesecar

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2008-10-13T00:00:00Z

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23316520

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severe acute respiratory syndrome-related coronavirus

severe acute respiratory syndrome coronavirus

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