Ranolazine antagonizes the effects of increased late sodium current on intracellular calcium cycling in rat isolated intact heart.
about
Recent advances in the management of chronic stable angina II. Anti-ischemic therapy, options for refractory angina, risk factor reduction, and revascularization.Mechanisms of ventricular arrhythmias: from molecular fluctuations to electrical turbulenceProton-dependent inhibition of the cardiac sodium channel Nav1.5 by ranolazineSuppression of re-entrant and multifocal ventricular fibrillation by the late sodium current blocker ranolazineResveratrol attenuates the Na(+)-dependent intracellular Ca(2+) overload by inhibiting H(2)O(2)-induced increase in late sodium current in ventricular myocytesT-tubule disruption promotes calcium alternans in failing ventricular myocytes: mechanistic insights from computational modelingElectrophysiologic basis for the antiarrhythmic actions of ranolazine.Calcium-voltage coupling in the genesis of early and delayed afterdepolarizations in cardiac myocytesRanolazine stabilizes cardiac ryanodine receptors: a novel mechanism for the suppression of early afterdepolarization and torsades de pointes in long QT type 2.Role of late sodium current as a potential arrhythmogenic mechanism in the progression of pressure-induced heart disease.Pathophysiology of the cardiac late Na current and its potential as a drug target.The arrhythmogenic consequences of increasing late INa in the cardiomyocyte.Dynamics of the late Na(+) current during cardiac action potential and its contribution to afterdepolarizations.Ranolazine for congenital and acquired late INa-linked arrhythmias: in silico pharmacological screening.Deranged sodium to sudden death.The Significance of the Late Na+ Current for Arrhythmia Induction and the Therapeutic Antiarrhythmic Potential of Ranolazine.Na+ dysregulation coupled with Ca2+ entry through NCX1 promotes muscular dystrophy in mice.Late INa increases diastolic SR-Ca2+-leak in atrial myocardium by activating PKA and CaMKII.Nav1.5-dependent persistent Na+ influx activates CaMKII in rat ventricular myocytes and N1325S mice.
P2860
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P2860
Ranolazine antagonizes the effects of increased late sodium current on intracellular calcium cycling in rat isolated intact heart.
description
2009 nî lūn-bûn
@nan
2009 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Ranolazine antagonizes the eff ...... in rat isolated intact heart.
@ast
Ranolazine antagonizes the eff ...... in rat isolated intact heart.
@en
type
label
Ranolazine antagonizes the eff ...... in rat isolated intact heart.
@ast
Ranolazine antagonizes the eff ...... in rat isolated intact heart.
@en
prefLabel
Ranolazine antagonizes the eff ...... in rat isolated intact heart.
@ast
Ranolazine antagonizes the eff ...... in rat isolated intact heart.
@en
P2093
P356
P1476
Ranolazine antagonizes the eff ...... in rat isolated intact heart.
@en
P2093
Gary L Aistrup
J Andrew Wasserstrom
James E Kelly
Jiabo Zheng
John Shryock
Luiz Belardinelli
Matthew J O'Toole
Rohan Sharma
P304
P356
10.1124/JPET.109.156471
P407
P577
2009-08-12T00:00:00Z