Ranolazine stabilizes cardiac ryanodine receptors: a novel mechanism for the suppression of early afterdepolarization and torsades de pointes in long QT type 2.
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Calcium dysregulation in atrial fibrillation: the role of CaMKIIPatient Specific Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Development and Screening In Catecholaminergic Polymorphic Ventricular TachycardiaCell model of catecholaminergic polymorphic ventricular tachycardia reveals early and delayed afterdepolarizationsPharmacological correction of long QT-linked mutations in KCNH2 (hERG) increases the trafficking of Kv11.1 channels stored in the transitional endoplasmic reticulum.Inhibition of the late sodium current slows t-tubule disruption during the progression of hypertensive heart disease in the rat.Resveratrol attenuates the Na(+)-dependent intracellular Ca(2+) overload by inhibiting H(2)O(2)-induced increase in late sodium current in ventricular myocytesHyperphosphorylation of RyRs underlies triggered activity in transgenic rabbit model of LQT2 syndrome.Carvedilol analogue inhibits triggered activities evoked by both early and delayed afterdepolarizationsIn silico prediction of drug therapy in catecholaminergic polymorphic ventricular tachycardia.Role of late sodium current as a potential arrhythmogenic mechanism in the progression of pressure-induced heart disease.New directions in antiarrhythmic drug therapy for atrial fibrillation.Electrical storm: recent pathophysiological insights and therapeutic consequences.Antiarrhythmic drugs 2013: state of the art.Pharmacotherapy for inherited arrhythmia syndromes: mechanistic basis, clinical trial evidence and practical application.Ranolazine: safe and effective in a patient with hypertensive cardiomyopathy and multiple episodes of electrical storm.A novel computational model of mouse myocyte electrophysiology to assess the synergy between Na+ loading and CaMKII.A TTX-sensitive resting Na+ permeability contributes to the catecholaminergic automatic activity in rat pulmonary vein.Atrial-selective targeting of arrhythmogenic phase-3 early afterdepolarizations in human myocytesTriggered intracellular calcium waves in dog and human left atrial myocytes from normal and failing hearts.A model of cardiac ryanodine receptor gating predicts experimental Ca2+-dynamics and Ca2+-triggered arrhythmia in the long QT syndrome.Ca2+ leak-What is it? Why should we care? Can it be managed?[New developments in the antiarrhythmic therapy of atrial fibrillation].Further insights into the underlying electrophysiological mechanisms for reduction of atrial fibrillation by ranolazine in an experimental model of chronic heart failure.Impact of ranolazine on ventricular arrhythmias - A systematic review.Selective late sodium current inhibitor GS-458967 suppresses Torsades de Pointes by mostly affecting perpetuation but not initiation of the arrhythmia.Late sodium current inhibitors to treat exercise-induced obstruction in hypertrophic cardiomyopathy: an in vitro study in human myocardium.Altered Ca and Na Homeostasis in Human Hypertrophic Cardiomyopathy: Implications for Arrhythmogenesis
P2860
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P2860
Ranolazine stabilizes cardiac ryanodine receptors: a novel mechanism for the suppression of early afterdepolarization and torsades de pointes in long QT type 2.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Ranolazine stabilizes cardiac ...... de pointes in long QT type 2.
@ast
Ranolazine stabilizes cardiac ...... de pointes in long QT type 2.
@en
type
label
Ranolazine stabilizes cardiac ...... de pointes in long QT type 2.
@ast
Ranolazine stabilizes cardiac ...... de pointes in long QT type 2.
@en
prefLabel
Ranolazine stabilizes cardiac ...... de pointes in long QT type 2.
@ast
Ranolazine stabilizes cardiac ...... de pointes in long QT type 2.
@en
P2093
P2860
P1433
P1476
Ranolazine stabilizes cardiac ...... de pointes in long QT type 2.
@en
P2093
Ashish Parikh
Dmitry Kozhevnikov
Guy Salama
Jonathan J Abramson
Jose Luis Puglisi
Laura J Owen
Michael A Roche
Rajkumar Mantravadi
Yanping Ye
P2860
P304
P356
10.1016/J.HRTHM.2012.01.010
P577
2012-01-11T00:00:00Z