Chemical library screens targeting an HIV-1 accessory factor/host cell kinase complex identify novel antiretroviral compounds - Wikidata - awgldk - TriplyDB

Chemical library screens targeting an HIV-1 accessory factor/host cell kinase complex identify novel antiretroviral compounds

Chemical library screens targeting an HIV-1 accessory factor/host cell kinase complex identify novel antiretroviral compounds

http://www.wikidata.org/entity/Q33508889

about

Small molecule inhibitors of the HIV-1 virulence factor, Nef Crystal Structure of the Src Family Kinase Hck SH3-SH2 Linker Regulatory Region Supports an SH3-dominant Activation Mechanism Small-Molecule Inhibitors of the c-Fes Protein-Tyrosine Kinase The identification of a small molecule compound that reduces HIV-1 Nef-mediated viral infectivity enhancement Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef Dynamics of the Tec-family tyrosine kinase SH3 domains.Subtle Dynamic Changes Accompany Hck Activation by HIV-1 Nef and are Reversed by an Antiretroviral Kinase Inhibitor.A Discovery Strategy for Selective Inhibitors of c-Src in Complex with the Focal Adhesion Kinase SH3/SH2-binding Region.Interaction with the Src homology (SH3-SH2) region of the Src-family kinase Hck structures the HIV-1 Nef dimer for kinase activation and effector recruitment The accessory factor Nef links HIV-1 to Tec/Btk kinases in an Src homology 3 domain-dependent manner.HIV-1 infection of T cells and macrophages are differentially modulated by virion-associated Hck: a Nef-dependent phenomenon HIV-1 Nef interaction influences the ATP-binding site of the Src-family kinase, Hck Effector kinase coupling enables high-throughput screens for direct HIV-1 Nef antagonists with antiretroviral activity.Small molecule inhibition of HIV-1-induced MHC-I down-regulation identifies a temporally regulated switch in Nef action Therapeutic strategies underpinning the development of novel techniques for the treatment of HIV infection.Nef alleles from all major HIV-1 clades activate Src-family kinases and enhance HIV-1 replication in an inhibitor-sensitive manner.Identification of Hck inhibitors as hits for the development of antileukemia and anti-HIV agents.Formation of a unique cluster of G-quadruplex structures in the HIV-1 Nef coding region: implications for antiviral activity.Discovery of a diaminoquinoxaline benzenesulfonamide antagonist of HIV-1 Nef function using a yeast-based phenotypic screen On the solution conformation and dynamics of the HIV-1 viral infectivity factor Viral bimolecular fluorescence complementation: a novel tool to study intracellular vesicular trafficking pathways.Membrane-Associated Conformation of HIV-1 Nef Investigated with Hydrogen Exchange Mass Spectrometry at a Langmuir Monolayer.Synthesis and evaluation of orally active small molecule HIV-1 Nef antagonists.A dynamic G-quadruplex region regulates the HIV-1 long terminal repeat promoter Identification of a novel binding site between HIV type 1 Nef C-terminal flexible loop and AP2 required for Nef-mediated CD4 downregulation.Synthesis and structure-activity analysis of diphenylpyrazolodiazene inhibitors of the HIV-1 Nef virulence factor.Viral tricks to grid-lock the type I interferon system.Contributions of HIV-1 Nef to immune dysregulation in HIV-infected patients: a therapeutic target?Viral proteins and Src family kinases: Mechanisms of pathogenicity from a "liaison dangereuse".Novel virtual lead identification in the discovery of hematopoietic cell kinase (HCK) inhibitors: application of 3D QSAR and molecular dynamics simulation.HIV-I Nef inhibitors: a novel class of HIV-specific immune adjuvants in support of a cure.Remodeling of HIV-1 Nef Structure by Src-Family Kinase Binding.A single β-octyl glucoside molecule induces HIV-1 Nef dimer formation in the absence of partner protein binding.

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P2860

Chemical library screens targeting an HIV-1 accessory factor/host cell kinase complex identify novel antiretroviral compounds

http://www.wikidata.org/entity/Q33508889

description

2009 nî lūn-bûn

@nan

2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

Chemical library screens targe ...... novel antiretroviral compounds

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Chemical library screens targe ...... novel antiretroviral compounds

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type

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Chemical library screens targe ...... novel antiretroviral compounds

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Chemical library screens targe ...... novel antiretroviral compounds

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Chemical library screens targe ...... novel antiretroviral compounds

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Chemical library screens targe ...... novel antiretroviral compounds

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ACS Chemical Biology

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Chemical library screens targe ...... novel antiretroviral compounds

@en

P2093

Billy W Day

http://www.w3.org/2001/XMLSchema#string

Caleb Foster

http://www.w3.org/2001/XMLSchema#string

Edwina C Lerner

http://www.w3.org/2001/XMLSchema#string

Lori Emert-Sedlak

http://www.w3.org/2001/XMLSchema#string

Thomas E Smithgall

http://www.w3.org/2001/XMLSchema#string

Toshiaki Kodama

http://www.w3.org/2001/XMLSchema#string

Weixiang Dai

http://www.w3.org/2001/XMLSchema#string

P2860

HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell

Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4

The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling

Structure--function relationships in HIV-1 Nef.

Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor

RT loop flexibility enhances the specificity of Src family SH3 domains for HIV-1 Nef

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients

Nef: "necessary and enforcing factor" in HIV infection

Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection

P304

939-947

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scholarly article

P356

10.1021/CB900195C

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11

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4

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2009-11-01T00:00:00Z

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26874221

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19807124

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P921

antiretroviral drug

P932

2861989

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