Syntheses of aminoalcohol-derived macrocycles leading to a small-molecule binder to and inhibitor of Sonic Hedgehog
about
Expanding the number of 'druggable' targets: non-enzymes and protein-protein interactionsHedgehog signaling pathway and its targets for treatment in basal cell carcinomaHedgehog Pathway Antagonist 5E1 Binds Hedgehog at the Pseudo-active SiteExpanding the range of 'druggable' targets with natural product-based libraries: an academic perspective.Comprehensive survey of chemical libraries for drug discovery and chemical biology: 2009.Fragment-based domain shuffling approach for the synthesis of pyran-based macrocycles.Diversity-oriented synthesis: producing chemical tools for dissecting biology.Concise synthesis and biological assessment of (+)-neopeltolide and a 16-member stereoisomer library of 8,9-dehydroneopeltolide: identification of pharmacophoric elements.Small molecule inhibitors of Smoothened ciliary localization and ciliogenesisSmall molecule inhibitors of the hedgehog signaling pathway for the treatment of cancer.Nonclassical hedgehog-GLI signaling and its clinical implications.Discovery and evaluation of potential sonic hedgehog signaling pathway inhibitors using pharmacophore modeling and molecular dynamics simulations.Tetrahydroquinoline-derived macrocyclic toolbox: the discovery of antiangiogenesis agents in zebrafish assay.Diversity-Oriented Synthesis as a Strategy for Fragment Evolution against GSK3βControl of olefin geometry in macrocyclic ring-closing metathesis using a removable silyl group.Macrocyclic Hedgehog Pathway Inhibitors: Optimization of Cellular Activity and Mode of Action Studies.Diversity-oriented synthesis of 13- to 18-membered macrolactams via ring-closing metathesis.Survey of the 2009 commercial optical biosensor literature.Strategies to target the Hedgehog signaling pathway for cancer therapy.Enantioselective total synthesis of colomitides and their absolute configuration determination and structural revision.
P2860
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P2860
Syntheses of aminoalcohol-derived macrocycles leading to a small-molecule binder to and inhibitor of Sonic Hedgehog
description
2009 nî lūn-bûn
@nan
2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
name
Syntheses of aminoalcohol-deri ...... nd inhibitor of Sonic Hedgehog
@ast
Syntheses of aminoalcohol-deri ...... nd inhibitor of Sonic Hedgehog
@en
type
label
Syntheses of aminoalcohol-deri ...... nd inhibitor of Sonic Hedgehog
@ast
Syntheses of aminoalcohol-deri ...... nd inhibitor of Sonic Hedgehog
@en
prefLabel
Syntheses of aminoalcohol-deri ...... nd inhibitor of Sonic Hedgehog
@ast
Syntheses of aminoalcohol-deri ...... nd inhibitor of Sonic Hedgehog
@en
P2093
P2860
P1476
Syntheses of aminoalcohol-deri ...... nd inhibitor of Sonic Hedgehog
@en
P2093
Lee F Peng
Nicole Maloof
Stuart L Schreiber
Xiang Wang
P2860
P304
P356
10.1016/J.BMCL.2009.09.089
P407
P577
2009-09-25T00:00:00Z