Misfolded proinsulin affects bystander proinsulin in neonatal diabetes
about
INS-gene mutations: from genetics and beta cell biology to clinical diseaseNeonatal diabetes: an expanding list of genes allows for improved diagnosis and treatmentGenetics and pathophysiology of neonatal diabetes mellitus.Stimulation of autophagy improves endoplasmic reticulum stress-induced diabetesMonitoring C-Peptide Storage and Secretion in Islet β-Cells In Vitro and In Vivo.Transgenic zebrafish model of the C43G human insulin gene mutationMutant INS-gene induced diabetes of youth: proinsulin cysteine residues impose dominant-negative inhibition on wild-type proinsulin transportHyperglucagonemia in an animal model of insulin- deficient diabetes: what therapy can improve it?Proinsulin misfolding and diabetes: mutant INS gene-induced diabetes of youth.Clinical and molecular genetics of neonatal diabetes due to mutations in the insulin gene.Insulin therapy for pre-hyperglycemic beta-cell endoplasmic reticulum crowding.A model of threshold behavior reveals rescue mechanisms of bystander proteins in conformational diseasesIn vivo misfolding of proinsulin below the threshold of frank diabetes.Impaired cleavage of preproinsulin signal peptide linked to autosomal-dominant diabetesIslet autoantigens: structure, function, localization, and regulation.A Bystander Mechanism Explains the Specific Phenotype of a Broadly Expressed Misfolded Protein.Transgenic expression of the human growth hormone minigene promotes pancreatic β-cell proliferationProinsulin intermolecular interactions during secretory trafficking in pancreatic β cellsDominant protein interactions that influence the pathogenesis of conformational diseases.Diabetes mellitus due to the toxic misfolding of proinsulin variants.Endoplasmic reticulum oxidoreductin-1α (Ero1α) improves folding and secretion of mutant proinsulin and limits mutant proinsulin-induced endoplasmic reticulum stress.Signaling from the secretory granule to the nucleus.Therapeutic potential of pterostilbene against pancreatic beta-cell apoptosis mediated through Nrf2.PERK in beta cell biology and insulin biogenesis.Endoplasmic reticulum stress and pancreatic β-cell death.Autophagy in adipose tissue and the beta cell: implications for obesity and diabetes.Insulin gene mutations and diabetesPermanent neonatal diabetes in INS(C94Y) transgenic pigs.Insulin promoter-driven Gaussia luciferase-based insulin secretion biosensor assay for discovery of β-cell glucose-sensing pathways.[Endoplasmic reticulum stress: from physiology to pathogenesis of type 2 diabetes].Impaired islet function in commonly used transgenic mouse lines due to human growth hormone minigene expression.
P2860
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P2860
Misfolded proinsulin affects bystander proinsulin in neonatal diabetes
description
2009 nî lūn-bûn
@nan
2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Misfolded proinsulin affects bystander proinsulin in neonatal diabetes
@ast
Misfolded proinsulin affects bystander proinsulin in neonatal diabetes
@en
Misfolded proinsulin affects bystander proinsulin in neonatal diabetes.
@nl
type
label
Misfolded proinsulin affects bystander proinsulin in neonatal diabetes
@ast
Misfolded proinsulin affects bystander proinsulin in neonatal diabetes
@en
Misfolded proinsulin affects bystander proinsulin in neonatal diabetes.
@nl
prefLabel
Misfolded proinsulin affects bystander proinsulin in neonatal diabetes
@ast
Misfolded proinsulin affects bystander proinsulin in neonatal diabetes
@en
Misfolded proinsulin affects bystander proinsulin in neonatal diabetes.
@nl
P2093
P2860
P356
P1476
Misfolded proinsulin affects bystander proinsulin in neonatal diabetes
@en
P2093
Aaron Adams
Dennis Larkin
Gautam Rajpal
Israel Hodish
Leanza Liu
Peter Arvan
Ronald W Holz
P2860
P304
P356
10.1074/JBC.M109.038042
P407
P577
2009-10-30T00:00:00Z