Lipoxygenase inhibitors as potential cancer chemopreventives.
about
Lipoxygenase and cyclooxygenase metabolism: new insights in treatment and chemoprevention of pancreatic cancerEicosanoid pathway in colorectal cancer: Recent updatesStructure based design and synthesis of peptide inhibitor of human LOX-12: in vitro and in vivo analysis of a novel therapeutic agent for breast cancerEmerging targets in lipid-based therapySynthesis and evaluation of LOX inhibitory activity of 2-(1,3-Dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-N-phenylacetamide derivativesDiscovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse librariesDiscovery of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1.Inhalation of an ethanol-based zileuton formulation provides a reduction of pulmonary adenomas in the A/J mouse model.Expression of 5-lipoxygenase in human colorectal cancerDiscovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.Mechanistic investigations of human reticulocyte 15- and platelet 12-lipoxygenases with arachidonic acid.Structural origins for the loss of catalytic activities of bifunctional human LTA4H revealed through molecular dynamics simulations.Down-regulation of vinculin upon MK886-induced apoptosis in LN18 glioblastoma cellsDesign, synthesis, and computational studies on dihydropyrimidine scaffolds as potential lipoxygenase inhibitors and cancer chemopreventive agents.Inhibition of aldose reductase prevents endotoxin-induced inflammation by regulating the arachidonic acid pathway in murine macrophages.Chemoprevention of colon and small intestinal tumorigenesis in APC(Min/+) mice by licofelone, a novel dual 5-LOX/COX inhibitor: potential implications for human colon cancer prevention.The eicosanoid cascade: possible role in gliomas and meningiomas.Anti-inflammatory effects of benfotiamine are mediated through the regulation of the arachidonic acid pathway in macrophages.Association of a functional polymorphism (Gln261Arg) in 12-lipoxygenase with breast cancer.Structure and ligand based drug design strategies in the development of novel 5- LOX inhibitors.Investigations of human platelet-type 12-lipoxygenase: role of lipoxygenase products in platelet activation.Lipoxygenase and Cyclooxygenase Pathways and Colorectal Cancer PreventionInhibition of lipoxygenases and cyclooxygenases by linoleyl hydroxamic acid: comparative in vitro studies.12-HETER1/GPR31, a high-affinity 12(S)-hydroxyeicosatetraenoic acid receptor, is significantly up-regulated in prostate cancer and plays a critical role in prostate cancer progression.Substrate specificity changes for human reticulocyte and epithelial 15-lipoxygenases reveal allosteric product regulation.Topical chemoprevention of skin cancer in mice, using combined inhibitors of 5-lipoxygenase and cyclo-oxygenase-2.A Novel Inhibitor of 5-Lipoxygenase (5-LOX) Prevents Oxidative Stress-Induced Cell Death of Retinal Pigment Epithelium (RPE) Cells5-Lipoxygenase-mediated endogenous DNA damage.Substrate specificity effects of lipoxygenase products and inhibitors on soybean lipoxygenase-1.Redox-active antioxidant modulation of lipid signaling in vascular endothelial cells: vitamin C induces activation of phospholipase D through phospholipase A2, lipoxygenase, and cyclooxygenase.Kinetic and structural investigations of the allosteric site in human epithelial 15-lipoxygenase-2.Novel dual cyclooxygenase and lipoxygenase inhibitors targeting hyaluronan-CD44v6 pathway and inducing cytotoxicity in colon cancer cells.First Selective 12-LOX Inhibitor, ML355, Impairs Thrombus Formation and Vessel Occlusion In Vivo With Minimal Effects on Hemostasis.Synthesis and Biological Evaluation of N-(5-(pyridin-2-yl)-1,3,4-thiadiazol-2-yl)benzamide Derivatives as Lipoxygenase Inhibitor with Potential Anticancer Activity.Phthalimide analogs as probable 15-lipoxygenase-1 inhibitors: synthesis, biological evaluation and docking studies.Impact of distal mutation on hydrogen transfer interface and substrate conformation in soybean lipoxygenase.Study of the polymorphisms of cyclooxygenase-2 (-765G>C) and 5-lipoxygenase (1708G>A) in patients with colorectal cancer.Protein profiling of plasma membranes defines aberrant signaling pathways in mantle cell lymphoma.High-throughput cell-based compound screen identifies pinosylvin methyl ether and tanshinone IIA as inhibitors of castration-resistant prostate cancer.Synthesis and evaluation of 5-lipoxygenase translocation inhibitors from acylnitroso hetero-Diels-Alder cycloadducts.
P2860
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P2860
Lipoxygenase inhibitors as potential cancer chemopreventives.
description
1999 nî lūn-bûn
@nan
1999 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Lipoxygenase inhibitors as potential cancer chemopreventives.
@ast
Lipoxygenase inhibitors as potential cancer chemopreventives.
@en
type
label
Lipoxygenase inhibitors as potential cancer chemopreventives.
@ast
Lipoxygenase inhibitors as potential cancer chemopreventives.
@en
prefLabel
Lipoxygenase inhibitors as potential cancer chemopreventives.
@ast
Lipoxygenase inhibitors as potential cancer chemopreventives.
@en
P2093
P1476
Lipoxygenase inhibitors as potential cancer chemopreventives.
@en
P2093
Crowell JA
Kelloff GJ
Kopelovich L
P304
P577
1999-05-01T00:00:00Z